26. HTLV-1関連脊髄症 Disease details / Clinical trials / Drug dev / DR info


臨床試験数 : 32 / 薬物数 : 46 - (DrugBank : 27) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 124

薬物、開発者(Primary Sponsor)、臨床試験情報(症例登録開始年(Enrollment year)、フェーズ、ID、実施国)
Amniotic epithelial cells
   The Second Affiliated Hospital of Fujian Medical University
      2016   Phase 1   NCT02961712   China
Biospecimen collection
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Bone marrow biopsy
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Bortezomib
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
CHOP-daclizumab
   King's College Hospital NHS Trust
      2010   Phase 4   NCT01418430   United Kingdom
Ciclosporin
   Imperial College London
      2006   Phase 2/Phase 3   NCT00773292   United Kingdom
Computed tomography
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Costicosteroids
   University of Sao Paulo
      2008   Phase 3   NCT00681980   Brazil
Cyclophosphamide
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
Darifenacin
   Hospital Universitário Professor Edgard Santos
      2022   Phase 4   NCT06616675   Brazil
Doxorubicin
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
Doxorubicin hydrochloride
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Etoposide
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
Filgrastim
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
HU MIK-BETA-1
   National Institute of Neurological Disorders and Stroke (NINDS)
      2004   Phase 1   NCT00076843   United States
KW-0761 0.3 MG/KG IV
   Kyowa Kirin Co., Ltd.
      2017   Phase 3   NCT03191526   Japan
Laboratory biomarker analysis
   Mayo Clinic
      2017   Phase 2   NCT03075553   United States
   National Cancer Institute (NCI)
      2017   Phase 2   NCT02631746   United States
Lamivudine
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
Lenalidomide
   Columbia University
      2010   Phase 2   NCT01274533   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Methylprednisolone
   St. Marianna University School of Medicine Hospital
      2016   -   JPRN-UMIN000024086   Japan
      2016   Phase 2,3   JPRN-UMIN000023798   Japan
Mogamulizumab
   Japan Agency for Medical Research and Development
      2015   Phase 1   JPRN-UMIN000016683   Japan
   Kyowa Kirin Co., Ltd.
      2017   Phase 3   JPRN-jRCT2080223553   Japan
   Memorial Sloan Kettering Cancer Center
      2024   Phase 2   NCT06698003   United States
MT-3921
   Mitsubishi Tanabe Pharma Corporation
      2022   Phase 1   NCT05240612   Japan
Neuromodulation - sacral nerve stimulation
   Hospital Universitário Professor Edgard Santos
      2022   Phase 4   NCT06616675   Brazil
Nivolumab
   Mayo Clinic
      2017   Phase 2   NCT03075553   United States
   National Cancer Institute (NCI)
      2017   Phase 2   NCT02631746   United States
NK cells
   The Second Affiliated Hospital of Fujian Medical University
      2016   Phase 1   NCT02961712   China
PEG-interferon ALFA-2B
   University of Miami
      2007   Phase 4   NCT00854581   United States
Pentosan polysulfate
   ReqMed Company, Ltd
      2014   Phase 2   JPRN-UMIN000015587   Japan
Pentoxifylline
   Hospital Universitário Professor Edgard Santos
      2009   Phase 3   NCT01472263   Brazil
Pharmacogenomic study
   National Cancer Institute (NCI)
      2017   Phase 2   NCT02631746   United States
Positron emission tomography
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Prednisolone
   St. Marianna University School of Medicine Hospital
      2016   -   JPRN-UMIN000024086   Japan
      2016   Phase 2,3   JPRN-UMIN000024085   Japan
      2016   Phase 2,3   JPRN-UMIN000023798   Japan
Prednisone
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
Propantheline bromide
   Hospital Universitário Professor Edgard Santos
      2012   Phase 1   NCT01640002   Brazil
Raltegravir
   National Institute of Neurological Disorders and Stroke (NINDS)
      2013   Early Phase 1   NCT01867320   United States
   Washington University School of Medicine
      2012   Phase 2   NCT01620736   United States
      2010   Phase 1/Phase 2   NCT01000285   United States
Raltegravir and zidovudine
   Universidad Peruana Cayetano Heredia
      2017   Early Phase 1   NCT02655471   Peru
Recombinant human interferon BETA-1A
   National Institute of Neurological Disorders and Stroke (NINDS)
      1998   Phase 2   NCT00001785   United States
Recombinant interferon alfa
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
Rituximab
   First Affiliated Hospital of Fujian Medical University
      2019   Phase 2   NCT04004819   China
Tamibarotene
   St. Marianna University School of Medicine
      2011   Phase 2/Phase 3   NCT01343355   Japan
Teriflunomide
   National Institute of Neurological Disorders and Stroke (NINDS)
      2021   Phase 1/Phase 2   NCT04799288   United States
Valproic acid
   University of Miami
      2007   Phase 4   NCT00854581   United States
   University of Sao Paulo
      2008   Phase 3   NCT00681980   Brazil
Valproid acid plus corticosteroids
   University of Sao Paulo
      2008   Phase 3   NCT00681980   Brazil
Vincristine
   Washington University School of Medicine
      2010   Phase 1/Phase 2   NCT01000285   United States
Vincristine sulfate
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   National Cancer Institute (NCI)
      2021   Phase 1   NCT04301076   United States
Zidovudine
   AIDS Malignancy Consortium
      2002   Phase 2   NCT00041327   United States
   University of Miami
      2007   Phase 4   NCT00854581   United States
Zidovudine/lamivudine
   Imperial College London
      1999   Phase 2/Phase 3   NCT00272480   United Kingdom