26. HTLV-1関連脊髄症 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 32 / 薬物数 : 46 - (DrugBank : 27) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 124
薬物、開発者(Primary Sponsor)、臨床試験情報(症例登録開始年(Enrollment year)、フェーズ、ID、実施国)
Amniotic epithelial cells
The Second Affiliated Hospital of Fujian Medical University
2016 Phase 1 NCT02961712 China
Biospecimen collection
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Bone marrow biopsy
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Bortezomib
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
CHOP-daclizumab
King's College Hospital NHS Trust
2010 Phase 4 NCT01418430 United Kingdom
Ciclosporin
Imperial College London
2006 Phase 2/Phase 3 NCT00773292 United Kingdom
Computed tomography
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Costicosteroids
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Cyclophosphamide
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Darifenacin
Hospital Universitário Professor Edgard Santos
2022 Phase 4 NCT06616675 Brazil
Doxorubicin
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Doxorubicin hydrochloride
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Etoposide
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Filgrastim
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
HU MIK-BETA-1
National Institute of Neurological Disorders and Stroke (NINDS)
2004 Phase 1 NCT00076843 United States
KW-0761 0.3 MG/KG IV
Kyowa Kirin Co., Ltd.
2017 Phase 3 NCT03191526 Japan
Laboratory biomarker analysis
Mayo Clinic
2017 Phase 2 NCT03075553 United States
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
Lamivudine
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
Lenalidomide
Columbia University
2010 Phase 2 NCT01274533 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Methylprednisolone
St. Marianna University School of Medicine Hospital
2016 - JPRN-UMIN000024086 Japan
2016 Phase 2,3 JPRN-UMIN000023798 Japan
Mogamulizumab
Japan Agency for Medical Research and Development
2015 Phase 1 JPRN-UMIN000016683 Japan
Kyowa Kirin Co., Ltd.
2017 Phase 3 JPRN-jRCT2080223553 Japan
Memorial Sloan Kettering Cancer Center
2024 Phase 2 NCT06698003 United States
MT-3921
Mitsubishi Tanabe Pharma Corporation
2022 Phase 1 NCT05240612 Japan
Neuromodulation - sacral nerve stimulation
Hospital Universitário Professor Edgard Santos
2022 Phase 4 NCT06616675 Brazil
Nivolumab
Mayo Clinic
2017 Phase 2 NCT03075553 United States
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
NK cells
The Second Affiliated Hospital of Fujian Medical University
2016 Phase 1 NCT02961712 China
PEG-interferon ALFA-2B
University of Miami
2007 Phase 4 NCT00854581 United States
Pentosan polysulfate
ReqMed Company, Ltd
2014 Phase 2 JPRN-UMIN000015587 Japan
Pentoxifylline
Hospital Universitário Professor Edgard Santos
2009 Phase 3 NCT01472263 Brazil
Pharmacogenomic study
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
Positron emission tomography
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Prednisolone
St. Marianna University School of Medicine Hospital
2016 - JPRN-UMIN000024086 Japan
2016 Phase 2,3 JPRN-UMIN000024085 Japan
2016 Phase 2,3 JPRN-UMIN000023798 Japan
Prednisone
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Propantheline bromide
Hospital Universitário Professor Edgard Santos
2012 Phase 1 NCT01640002 Brazil
Raltegravir
National Institute of Neurological Disorders and Stroke (NINDS)
2013 Early Phase 1 NCT01867320 United States
Washington University School of Medicine
2012 Phase 2 NCT01620736 United States
2010 Phase 1/Phase 2 NCT01000285 United States
Raltegravir and zidovudine
Universidad Peruana Cayetano Heredia
2017 Early Phase 1 NCT02655471 Peru
Recombinant human interferon BETA-1A
National Institute of Neurological Disorders and Stroke (NINDS)
1998 Phase 2 NCT00001785 United States
Recombinant interferon alfa
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
Rituximab
First Affiliated Hospital of Fujian Medical University
2019 Phase 2 NCT04004819 China
Tamibarotene
St. Marianna University School of Medicine
2011 Phase 2/Phase 3 NCT01343355 Japan
Teriflunomide
National Institute of Neurological Disorders and Stroke (NINDS)
2021 Phase 1/Phase 2 NCT04799288 United States
Valproic acid
University of Miami
2007 Phase 4 NCT00854581 United States
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Valproid acid plus corticosteroids
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Vincristine
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Vincristine sulfate
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Zidovudine
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
University of Miami
2007 Phase 4 NCT00854581 United States
Zidovudine/lamivudine
Imperial College London
1999 Phase 2/Phase 3 NCT00272480 United Kingdom
The Second Affiliated Hospital of Fujian Medical University
2016 Phase 1 NCT02961712 China
Biospecimen collection
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Bone marrow biopsy
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Bortezomib
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
CHOP-daclizumab
King's College Hospital NHS Trust
2010 Phase 4 NCT01418430 United Kingdom
Ciclosporin
Imperial College London
2006 Phase 2/Phase 3 NCT00773292 United Kingdom
Computed tomography
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Costicosteroids
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Cyclophosphamide
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Darifenacin
Hospital Universitário Professor Edgard Santos
2022 Phase 4 NCT06616675 Brazil
Doxorubicin
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Doxorubicin hydrochloride
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Etoposide
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Filgrastim
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
HU MIK-BETA-1
National Institute of Neurological Disorders and Stroke (NINDS)
2004 Phase 1 NCT00076843 United States
KW-0761 0.3 MG/KG IV
Kyowa Kirin Co., Ltd.
2017 Phase 3 NCT03191526 Japan
Laboratory biomarker analysis
Mayo Clinic
2017 Phase 2 NCT03075553 United States
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
Lamivudine
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
Lenalidomide
Columbia University
2010 Phase 2 NCT01274533 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Methylprednisolone
St. Marianna University School of Medicine Hospital
2016 - JPRN-UMIN000024086 Japan
2016 Phase 2,3 JPRN-UMIN000023798 Japan
Mogamulizumab
Japan Agency for Medical Research and Development
2015 Phase 1 JPRN-UMIN000016683 Japan
Kyowa Kirin Co., Ltd.
2017 Phase 3 JPRN-jRCT2080223553 Japan
Memorial Sloan Kettering Cancer Center
2024 Phase 2 NCT06698003 United States
MT-3921
Mitsubishi Tanabe Pharma Corporation
2022 Phase 1 NCT05240612 Japan
Neuromodulation - sacral nerve stimulation
Hospital Universitário Professor Edgard Santos
2022 Phase 4 NCT06616675 Brazil
Nivolumab
Mayo Clinic
2017 Phase 2 NCT03075553 United States
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
NK cells
The Second Affiliated Hospital of Fujian Medical University
2016 Phase 1 NCT02961712 China
PEG-interferon ALFA-2B
University of Miami
2007 Phase 4 NCT00854581 United States
Pentosan polysulfate
ReqMed Company, Ltd
2014 Phase 2 JPRN-UMIN000015587 Japan
Pentoxifylline
Hospital Universitário Professor Edgard Santos
2009 Phase 3 NCT01472263 Brazil
Pharmacogenomic study
National Cancer Institute (NCI)
2017 Phase 2 NCT02631746 United States
Positron emission tomography
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Prednisolone
St. Marianna University School of Medicine Hospital
2016 - JPRN-UMIN000024086 Japan
2016 Phase 2,3 JPRN-UMIN000024085 Japan
2016 Phase 2,3 JPRN-UMIN000023798 Japan
Prednisone
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Propantheline bromide
Hospital Universitário Professor Edgard Santos
2012 Phase 1 NCT01640002 Brazil
Raltegravir
National Institute of Neurological Disorders and Stroke (NINDS)
2013 Early Phase 1 NCT01867320 United States
Washington University School of Medicine
2012 Phase 2 NCT01620736 United States
2010 Phase 1/Phase 2 NCT01000285 United States
Raltegravir and zidovudine
Universidad Peruana Cayetano Heredia
2017 Early Phase 1 NCT02655471 Peru
Recombinant human interferon BETA-1A
National Institute of Neurological Disorders and Stroke (NINDS)
1998 Phase 2 NCT00001785 United States
Recombinant interferon alfa
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
Rituximab
First Affiliated Hospital of Fujian Medical University
2019 Phase 2 NCT04004819 China
Tamibarotene
St. Marianna University School of Medicine
2011 Phase 2/Phase 3 NCT01343355 Japan
Teriflunomide
National Institute of Neurological Disorders and Stroke (NINDS)
2021 Phase 1/Phase 2 NCT04799288 United States
Valproic acid
University of Miami
2007 Phase 4 NCT00854581 United States
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Valproid acid plus corticosteroids
University of Sao Paulo
2008 Phase 3 NCT00681980 Brazil
Vincristine
Washington University School of Medicine
2010 Phase 1/Phase 2 NCT01000285 United States
Vincristine sulfate
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
National Cancer Institute (NCI)
2021 Phase 1 NCT04301076 United States
Zidovudine
AIDS Malignancy Consortium
2002 Phase 2 NCT00041327 United States
University of Miami
2007 Phase 4 NCT00854581 United States
Zidovudine/lamivudine
Imperial College London
1999 Phase 2/Phase 3 NCT00272480 United Kingdom