56. ベーチェット病 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 87 / 薬物数 : 90 - (DrugBank : 35) / 標的遺伝子数 : 41 - 標的パスウェイ数 : 126
薬物、開発者(Primary Sponsor)、臨床試験情報(症例登録開始年(Enrollment year)、フェーズ、ID、実施国)
Adalimumab
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
AbbVie (prior sponsor, Abbott)
2010 Phase 3 NCT01243671 Japan
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
2020 Phase 4 ChiCTR1900027147 China
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
The First Affiliated Hospital, College of Medicine, Zhejiang University
2021 Phase 4 ChiCTR2100045463 China
AIN457
Novartis Farmacéutica, S.A.
2010 - EUCTR2009-013901-33-ES Austria;France;Germany;Greece;Spain
2009 Phase 3 EUCTR2009-011237-27-ES Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharma Services AG
2010 - EUCTR2009-013901-33-GR Austria;France;Germany;Greece;Spain
2010 - EUCTR2009-013901-33-FR Austria;France;Germany;Greece;Spain
2010 - EUCTR2009-013901-33-DE Austria;France;Germany;Greece;Spain
2009 - EUCTR2009-013901-33-AT Austria;France;Germany;Greece;Spain
2009 - EUCTR2009-011237-27-DE Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-AT Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharma Services Ag
2009 - EUCTR2009-011237-27-HU Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-GR Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-FR Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharmaceuticals
2009 Phase 3 NCT00995709 Austria;Brazil;Egypt;France;Germany;Greece;Hong Kong;Hungary;India;Israel;Italy;Jordan;Korea, Republic of;Saudi Arabia;Singapore;Spain;Switzerland;Taiwan;Tunisia;Turkey;United States
Allogeneic stem cell transplant
Northwestern University
2003 Phase 1 NCT00278512 United States
Alpha interferon
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
AMG 407
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
AMG-407
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
AMG407
AMGEN INC.
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Anakinra
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
2011 Phase 1/Phase 2 NCT01441076 United States
Apremilast
AMGEN INC.
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen
2023 Phase 3 NCT05767047 Greece;Israel;Spain;Turkey
2021 Phase 3 NCT04528082 France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2014 Phase 3 NCT02307513 France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Lebanon;Turkey;United States
Amgen Inc.
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Celgene Corporation
2016 Phase 3 EUCTR2014-002108-25-GR France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
2015 Phase 3 EUCTR2014-002108-25-IT France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Apremilast 10 MG
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Apremilast 20 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Apremilast 30 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Autologous stem cell transplant
Northwestern University
2003 Phase 1 NCT00278512 United States
Autologous stem cell transplantation
Tehran University of Medical Sciences
2007 Phase 1 NCT00550498 Iran, Islamic Republic of
BCMA-CD19 CAR-T therapy
Peking University People's Hospital
2024 Phase 2 NCT06794008 China
Betamethasone mouthwash
Cairo University
2023 Phase 1/Phase 2 NCT06084624 -
Biobanking with genetic analysis
University Hospital, Lille
2020 - NCT04334031 France
Canakinumab
Novartis Pharmaceuticals
2016 Phase 2 NCT02756650 Turkey
University Hospital of Tübingen
2011 Phase 3 EUCTR2010-024152-29-DE Germany
CC-10004
Amgen Inc.
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Celgene Corporation
2016 Phase 3 EUCTR2014-002108-25-GR France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
2015 Phase 3 EUCTR2014-002108-25-IT France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Colchicine
Ipekyolu Ilac Ltd. Sti
2019 Phase 2 NCT03888846 Turkey
Tehran University of Medical Sciences
2002 Phase 2 NCT00700297 Iran, Islamic Republic of
Crohn'S disease
The Affiliated Hospital of Qingdao University
2023 - ChiCTR2300073620 China
Cyclophosphamide
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
Assistance Publique - Hôpitaux de Paris
2018 Phase 3 NCT03371095 France
Cyclosporin A
University Hospital Tuebingen
2004 Phase 3 NCT00167583 Germany
Cyclosporine
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
Yokohama City University Hospital
2017 - JPRN-UMIN000025451 Japan
Cyclosporine pill
Peking Union Medical College Hospital
2017 Phase 3 NCT03209219 China
Cytotoxic combination
Tehran University of Medical Sciences
2006 Phase 2 NCT00664599 Iran, Islamic Republic of
Daclizumab
National Eye Institute (NEI)
1999 Phase 2 NCT00001865 United States
Dextrose
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Diode laser 980NM&100 mwatt
Cairo University
2019 - NCT03771768 -
Dusquetide
Soligenix
2024 Phase 2 NCT06386744 Turkey
Entecavir
Saitama Medical University
2016 - JPRN-UMIN000020029 Japan
Etanercept, methotrexate, prednisolone
Tehran University of Medical Sciences
2010 - NCT00931957 Iran, Islamic Republic of
Filgotinib
UMC Utrecht
2024 Phase 2 NCT06285539 Netherlands
Flucinolone acetonide
Asan Medical Center
2008 Phase 4 NCT00720928 Korea, Republic of
Gevokizumab
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
XOMA (US) LLC
2014 Phase 3 NCT02258867 United States
Golimumab
Wenjie Zheng
2020 Phase 2 NCT04218565 China
GSK1070806
Cambridge University Hospitals NHS Foundation Trust
2018 Phase 2 NCT03522662 United Kingdom
Hemay005
Ganzhou Hemay Pharmaceutical Co., Ltd
2023 Phase 3 NCT06145893 China
Tianjin Hemay Pharmaceutical Co., Ltd
2020 Phase 2 NCT04609397 China
Herpes zoster vaccine
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
Humira
Sohag University
2022 - NCT05683626 Egypt
Humira - 40 MG soluzione iniettabile USO sottocutaneo 1 siringa preriempita 0.8 ML + 1 tampone imbevuto DI alcol IN UN blister
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Humira 40MG, solution injectable EN stylo PRérempli
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Hydroxychloroquine
Assiut University
2018 - NCT04022421 Egypt
Ilaris
University Hospital of Tübingen
2011 Phase 3 EUCTR2010-024152-29-DE Germany
Inflectra - 100 MG - polvere PER concentrato PER soluzione PER infusione - USO endovenoso - flaconcino (vetro) - 1 flaconcino
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Infliximab
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Assistance Publique - Hôpitaux de Paris
2018 Phase 3 NCT03371095 France
Janssen Korea, Ltd., Korea
2015 Phase 3 NCT02505568 Korea, Republic of
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Yokohama City University Hospital
2017 - JPRN-UMIN000025451 Japan
Interferon ALFA-2A
Peking Union Medical College Hospital
2017 Phase 3 NCT03209219 China
Interferon alpha-2A
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
Interferon-alpha2A
University Hospital Tuebingen
2004 Phase 3 NCT00167583 Germany
Interleukin 2
Assistance Publique - Hôpitaux de Paris
2014 Phase 2 NCT01988506 France
Intravitreal infliximab
Cairo University
2013 Phase 1/Phase 2 NCT02620618 -
J1081
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
LOW-dose IL-2
HeJing
2021 Phase 2 NCT04065672 China
Medrol - 4 MG compresse 30 compresse
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Methylorednisolone
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Metilprednisolone sodio succinato
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
MMF discontinuation
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MMF maintain
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MTX discontinuation
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MTX maintain
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
Otezla
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Otezla - 10 MG + 20 MG + 30 MG compressa rivestita CON film USO orale - blister (PVC/ALU) IN UN astuccio - 4 compresse DA 10 MG + 4 compresse DA 20 MG +19 compresse DA 30 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Pentoxifylline
Ipekyolu Ilac Ltd. Sti
2019 Phase 2 NCT03888846 Turkey
Silk Road Therapies, Inc.
2024 Phase 2 NCT04186559 United States
Prednisolone
Castle Study Group
2013 - JPRN-UMIN000012469 Japan
Rebamipide mouthwash
Cairo University
2023 Phase 1/Phase 2 NCT06084624 -
Remicade
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Remicade 100 MG
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
Rituximab
Tehran University of Medical Sciences
2006 Phase 2 NCT00664599 Iran, Islamic Republic of
Rivaroxaban plus immunosupression
Marmara University
2025 Phase 3 NCT06925698 Turkey
Roactemra 162 MG solution injectable EN seringue PRéremplie
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Roferon-A 3MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 3MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 4.5MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 6MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Rosuvastatin calcium 40MG
University of Alexandria
2010 - NCT04328064 -
S78989
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Serum levels OF angiogenin, bfgf, vegf
Turkish Ophthalmology Society
2011 - NCT01720628 Turkey
SF-12 questionnaire
University Hospital, Lille
2020 - NCT04334031 France
Solu medrol - 40 MG/ML polvere E solvente PER soluzione iniettabile 1 flacone A doppia camera DA 40 MG/ML
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Solu medrol - 500 MG/8 ML polvere E solvente PER soluzione iniettabile 1 flacone DI polvere DA 500 MG+ fiala solvente DA 8 ML
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Stelara
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
2015 Phase 2 EUCTR2015-002190-37-FR France
Subcutaneous ustekinumab
Assistance Publique - Hôpitaux de Paris
2017 Phase 2 NCT02648581 France
TA-650
Mitsubishi Tanabe Pharma Corporation
2012 Phase 3 NCT01532570 Japan
Tacrolimus ointment
Assiut University
2019 - NCT05032248 Egypt
Thalidomide
Shanghai Traditional Chinese Medicine Hospital
2021 Phase 0 ChiCTR2000037172 China
Tocilizumab
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Wenjie Zheng
2018 Phase 2 NCT03554161 China
Triamcinolone acetonide
Cairo University
2019 - NCT03771768 -
Ustekinumab
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
2015 Phase 2 EUCTR2015-002190-37-FR France
Water
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Xoma 052
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
2010 Phase 1/Phase 2 NCT01211977 United States
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
AbbVie (prior sponsor, Abbott)
2010 Phase 3 NCT01243671 Japan
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University
2020 Phase 4 ChiCTR1900027147 China
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
The First Affiliated Hospital, College of Medicine, Zhejiang University
2021 Phase 4 ChiCTR2100045463 China
AIN457
Novartis Farmacéutica, S.A.
2010 - EUCTR2009-013901-33-ES Austria;France;Germany;Greece;Spain
2009 Phase 3 EUCTR2009-011237-27-ES Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharma Services AG
2010 - EUCTR2009-013901-33-GR Austria;France;Germany;Greece;Spain
2010 - EUCTR2009-013901-33-FR Austria;France;Germany;Greece;Spain
2010 - EUCTR2009-013901-33-DE Austria;France;Germany;Greece;Spain
2009 - EUCTR2009-013901-33-AT Austria;France;Germany;Greece;Spain
2009 - EUCTR2009-011237-27-DE Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-AT Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharma Services Ag
2009 - EUCTR2009-011237-27-HU Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-GR Austria;France;Germany;Greece;Hungary;Italy;Spain
2009 - EUCTR2009-011237-27-FR Austria;France;Germany;Greece;Hungary;Italy;Spain
Novartis Pharmaceuticals
2009 Phase 3 NCT00995709 Austria;Brazil;Egypt;France;Germany;Greece;Hong Kong;Hungary;India;Israel;Italy;Jordan;Korea, Republic of;Saudi Arabia;Singapore;Spain;Switzerland;Taiwan;Tunisia;Turkey;United States
Allogeneic stem cell transplant
Northwestern University
2003 Phase 1 NCT00278512 United States
Alpha interferon
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
AMG 407
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
AMG-407
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
AMG407
AMGEN INC.
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Anakinra
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
2011 Phase 1/Phase 2 NCT01441076 United States
Apremilast
AMGEN INC.
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Amgen
2023 Phase 3 NCT05767047 Greece;Israel;Spain;Turkey
2021 Phase 3 NCT04528082 France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2014 Phase 3 NCT02307513 France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Lebanon;Turkey;United States
Amgen Inc.
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Celgene Corporation
2016 Phase 3 EUCTR2014-002108-25-GR France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
2015 Phase 3 EUCTR2014-002108-25-IT France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Apremilast 10 MG
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Apremilast 20 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Apremilast 30 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Autologous stem cell transplant
Northwestern University
2003 Phase 1 NCT00278512 United States
Autologous stem cell transplantation
Tehran University of Medical Sciences
2007 Phase 1 NCT00550498 Iran, Islamic Republic of
BCMA-CD19 CAR-T therapy
Peking University People's Hospital
2024 Phase 2 NCT06794008 China
Betamethasone mouthwash
Cairo University
2023 Phase 1/Phase 2 NCT06084624 -
Biobanking with genetic analysis
University Hospital, Lille
2020 - NCT04334031 France
Canakinumab
Novartis Pharmaceuticals
2016 Phase 2 NCT02756650 Turkey
University Hospital of Tübingen
2011 Phase 3 EUCTR2010-024152-29-DE Germany
CC-10004
Amgen Inc.
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Celgene Corporation
2016 Phase 3 EUCTR2014-002108-25-GR France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
2015 Phase 3 EUCTR2014-002108-25-IT France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
Colchicine
Ipekyolu Ilac Ltd. Sti
2019 Phase 2 NCT03888846 Turkey
Tehran University of Medical Sciences
2002 Phase 2 NCT00700297 Iran, Islamic Republic of
Crohn'S disease
The Affiliated Hospital of Qingdao University
2023 - ChiCTR2300073620 China
Cyclophosphamide
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
Assistance Publique - Hôpitaux de Paris
2018 Phase 3 NCT03371095 France
Cyclosporin A
University Hospital Tuebingen
2004 Phase 3 NCT00167583 Germany
Cyclosporine
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
Yokohama City University Hospital
2017 - JPRN-UMIN000025451 Japan
Cyclosporine pill
Peking Union Medical College Hospital
2017 Phase 3 NCT03209219 China
Cytotoxic combination
Tehran University of Medical Sciences
2006 Phase 2 NCT00664599 Iran, Islamic Republic of
Daclizumab
National Eye Institute (NEI)
1999 Phase 2 NCT00001865 United States
Dextrose
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Diode laser 980NM&100 mwatt
Cairo University
2019 - NCT03771768 -
Dusquetide
Soligenix
2024 Phase 2 NCT06386744 Turkey
Entecavir
Saitama Medical University
2016 - JPRN-UMIN000020029 Japan
Etanercept, methotrexate, prednisolone
Tehran University of Medical Sciences
2010 - NCT00931957 Iran, Islamic Republic of
Filgotinib
UMC Utrecht
2024 Phase 2 NCT06285539 Netherlands
Flucinolone acetonide
Asan Medical Center
2008 Phase 4 NCT00720928 Korea, Republic of
Gevokizumab
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
XOMA (US) LLC
2014 Phase 3 NCT02258867 United States
Golimumab
Wenjie Zheng
2020 Phase 2 NCT04218565 China
GSK1070806
Cambridge University Hospitals NHS Foundation Trust
2018 Phase 2 NCT03522662 United Kingdom
Hemay005
Ganzhou Hemay Pharmaceutical Co., Ltd
2023 Phase 3 NCT06145893 China
Tianjin Hemay Pharmaceutical Co., Ltd
2020 Phase 2 NCT04609397 China
Herpes zoster vaccine
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
Humira
Sohag University
2022 - NCT05683626 Egypt
Humira - 40 MG soluzione iniettabile USO sottocutaneo 1 siringa preriempita 0.8 ML + 1 tampone imbevuto DI alcol IN UN blister
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Humira 40MG, solution injectable EN stylo PRérempli
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Hydroxychloroquine
Assiut University
2018 - NCT04022421 Egypt
Ilaris
University Hospital of Tübingen
2011 Phase 3 EUCTR2010-024152-29-DE Germany
Inflectra - 100 MG - polvere PER concentrato PER soluzione PER infusione - USO endovenoso - flaconcino (vetro) - 1 flaconcino
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Infliximab
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Assistance Publique - Hôpitaux de Paris
2018 Phase 3 NCT03371095 France
Janssen Korea, Ltd., Korea
2015 Phase 3 NCT02505568 Korea, Republic of
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Yokohama City University Hospital
2017 - JPRN-UMIN000025451 Japan
Interferon ALFA-2A
Peking Union Medical College Hospital
2017 Phase 3 NCT03209219 China
Interferon alpha-2A
The First Affiliated Hospital of Chongqing Medical University
2020 Phase 4 ChiCTR2000031637 China
Interferon-alpha2A
University Hospital Tuebingen
2004 Phase 3 NCT00167583 Germany
Interleukin 2
Assistance Publique - Hôpitaux de Paris
2014 Phase 2 NCT01988506 France
Intravitreal infliximab
Cairo University
2013 Phase 1/Phase 2 NCT02620618 -
J1081
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
LOW-dose IL-2
HeJing
2021 Phase 2 NCT04065672 China
Medrol - 4 MG compresse 30 compresse
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Methylorednisolone
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Metilprednisolone sodio succinato
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
MMF discontinuation
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MMF maintain
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MTX discontinuation
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
MTX maintain
University of Sao Paulo General Hospital
2023 Phase 4 NCT05879419 Brazil
Otezla
Amgen Inc
2023 Phase 3 EUCTR2022-003024-41-FR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2023 Phase 3 EUCTR2022-003024-41-ES France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
- Phase 3 EUCTR2022-003024-41-GR France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
Amgen Inc.
2021 Phase 3 EUCTR2019-002787-27-GR France;Greece;Israel;Italy;Netherlands;Switzerland
2021 Phase 3 EUCTR2019-002787-27-FR France;Greece;Israel;Italy;Netherlands;Switzerland
2015 Phase 3 EUCTR2014-002108-25-DE France;Germany;Greece;Israel;Italy;Japan;Korea, Republic of;Turkey;United States
- Phase 3 EUCTR2019-002787-27-NL France;Greece;Israel;Italy;Netherlands;Spain;Switzerland;United Kingdom
Otezla - 10 MG + 20 MG + 30 MG compressa rivestita CON film USO orale - blister (PVC/ALU) IN UN astuccio - 4 compresse DA 10 MG + 4 compresse DA 20 MG +19 compresse DA 30 MG
AMGEN INC.
2023 Phase 3 EUCTR2022-003024-41-IT France;Greece;Israel;Italy;Spain;Switzerland;Turkey;United Kingdom
2021 Phase 3 EUCTR2019-002787-27-IT France;Greece;Israel;Italy;Netherlands;Switzerland
Pentoxifylline
Ipekyolu Ilac Ltd. Sti
2019 Phase 2 NCT03888846 Turkey
Silk Road Therapies, Inc.
2024 Phase 2 NCT04186559 United States
Prednisolone
Castle Study Group
2013 - JPRN-UMIN000012469 Japan
Rebamipide mouthwash
Cairo University
2023 Phase 1/Phase 2 NCT06084624 -
Remicade
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Remicade 100 MG
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
- Phase 2 EUCTR2017-002264-41-FR France
Rituximab
Tehran University of Medical Sciences
2006 Phase 2 NCT00664599 Iran, Islamic Republic of
Rivaroxaban plus immunosupression
Marmara University
2025 Phase 3 NCT06925698 Turkey
Roactemra 162 MG solution injectable EN seringue PRéremplie
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Roferon-A 3MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 3MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 4.5MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Roferon-A, 6MIU
The University of Liverpool
2016 Phase 3 EUCTR2014-005390-36-GB United Kingdom
Rosuvastatin calcium 40MG
University of Alexandria
2010 - NCT04328064 -
S78989
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Serum levels OF angiogenin, bfgf, vegf
Turkish Ophthalmology Society
2011 - NCT01720628 Turkey
SF-12 questionnaire
University Hospital, Lille
2020 - NCT04334031 France
Solu medrol - 40 MG/ML polvere E solvente PER soluzione iniettabile 1 flacone A doppia camera DA 40 MG/ML
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Solu medrol - 500 MG/8 ML polvere E solvente PER soluzione iniettabile 1 flacone DI polvere DA 500 MG+ fiala solvente DA 8 ML
AZIENDA OSPEDALIERO-UNIVERSITARIA PISANA
2017 Phase 3 EUCTR2017-000845-39-IT Italy
Stelara
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
2015 Phase 2 EUCTR2015-002190-37-FR France
Subcutaneous ustekinumab
Assistance Publique - Hôpitaux de Paris
2017 Phase 2 NCT02648581 France
TA-650
Mitsubishi Tanabe Pharma Corporation
2012 Phase 3 NCT01532570 Japan
Tacrolimus ointment
Assiut University
2019 - NCT05032248 Egypt
Thalidomide
Shanghai Traditional Chinese Medicine Hospital
2021 Phase 0 ChiCTR2000037172 China
Tocilizumab
Assistance Publique Hôpitaux de Paris / DRCI
2022 Phase 2 EUCTR2022-001316-26-FR France
Wenjie Zheng
2018 Phase 2 NCT03554161 China
Triamcinolone acetonide
Cairo University
2019 - NCT03771768 -
Ustekinumab
ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)
2015 Phase 2 EUCTR2015-002190-37-FR France
Water
Tehran University of Medical Sciences
2010 Phase 4 NCT01306955 Iran, Islamic Republic of
Xoma 052
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER
2012 - EUCTR2012-001125-27-IT Brazil;China;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
Institut de Recherches Internationales Servier
2013 Phase 3 EUCTR2012-001125-27-PT Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2013 Phase 3 EUCTR2012-001125-27-GB Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-GR Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
2012 - EUCTR2012-001125-27-DE Brazil;China;France;Germany;Greece;Hong Kong;India;Italy;Korea, Republic of;Portugal;Russian Federation;Saudi Arabia;Spain;Tunisia;Turkey;United Kingdom
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
2010 Phase 1/Phase 2 NCT01211977 United States