89. リンパ脈管筋腫症 Disease details / Clinical trials / Drug dev / DR info
臨床試験数 : 44 / 薬物数 : 44 - (DrugBank : 20) / 標的遺伝子数 : 27 - 標的パスウェイ数 : 138
薬物、開発者(Primary Sponsor)、臨床試験情報(症例登録開始年(Enrollment year)、フェーズ、ID、実施国)
68GA-NEB
Peking Union Medical College Hospital
2019 Phase 1 NCT04273334 China
Acetate
Brigham and Women's Hospital
2021 Phase 1/Phase 2 NCT05467397 United States
Afinitor
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Afinitor 5MG tablets
Novartis Pharma Services AG
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Albuterol inhaler
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Albuterol nebulizer
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Assessment OF arterial stiffness using THE vasera VS-1500N
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
Bevacizumab
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Breath test using THE compact PTR-TOF-MS
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
Buccal (cheek) swab
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Celecoxib
Brigham and Women's Hospital
2016 Phase 2 NCT02484664 United States
Cetuximab
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Doxycycline
University of Nottingham
2009 Phase 4 NCT00989742 United Kingdom
Doxycycline 100 MG capsules
University of Nottingham
2008 - EUCTR2007-003745-32-GB United Kingdom
Everolimus
Children's Hospital Medical Center, Cincinnati
2008 Phase 1/Phase 2 NCT00792766 United States
NOVARTIS FARMA
2010 - EUCTR2010-019825-32-IT France;Italy
2009 - EUCTR2008-002113-48-IT France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
2010 - EUCTR2008-002113-48-NL France;Germany;Italy;Netherlands;Spain;United Kingdom
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
2009 Phase 3 EUCTR2008-002113-48-FR France;Germany;Italy;Netherlands;Spain;United Kingdom
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Novartis Pharmaceuticals
2010 Phase 2 NCT01059318 France;Germany;Italy;United States
2009 Phase 3 NCT00790400 Canada;France;Germany;Italy;Japan;Netherlands;Poland;Russian Federation;Spain;United Kingdom;United States
University of Cincinnati
2015 - NCT02432560 United States
Everolimus oral product
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Glutamine
Vanderbilt University Medical Center
2019 Phase 1 NCT04388371 United States
Imatimib mesylate
Columbia University
2025 Phase 1 NCT06889168 United States
Imatinib mesylate 400MG capsule
Medical University of South Carolina
2018 Phase 1/Phase 2 NCT03131999 United States
Laboratory biomarker analysis
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Letrozole
University of Cincinnati
2011 Phase 2 NCT01353209 United States
Loratadina stada 10 MG
IDIBELL (Institut d’Investigació Biomédica de Bellvitge)
2021 Phase 2 EUCTR2020-000702-29-ES Spain
Loratadine
IDIBELL (Institut d’Investigació Biomédica de Bellvitge)
2021 Phase 2 EUCTR2020-000702-29-ES Spain
Nintedanib
IRCCS Multimedica
2016 Phase 2 NCT03062943 Italy
Octreotide
National Heart, Lung, and Blood Institute (NHLBI)
2000 Phase 2 NCT00005906 United States
Ofev
MULTIMEDICA S.P.A.
2016 Phase 3 EUCTR2015-004919-20-IT Italy
PFT
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Pharmacological study
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Phlebotomy
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Portable cardiac monitor cardioqvark
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
RAD001
Children's Hospital Medical Center, Cincinnati
2008 Phase 1/Phase 2 NCT00792766 United States
2005 Phase 1/Phase 2 NCT00457964 United States
NOVARTIS FARMA
2010 - EUCTR2010-019825-32-IT France;Italy
2009 - EUCTR2008-002113-48-IT France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
2010 - EUCTR2008-002113-48-NL France;Germany;Italy;Netherlands;Spain;United Kingdom
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
2009 Phase 3 EUCTR2008-002113-48-FR France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharmaceuticals
2009 Phase 3 NCT00790400 Canada;France;Germany;Italy;Japan;Netherlands;Poland;Russian Federation;Spain;United Kingdom;United States
RAD001 5MG
Novartis Pharma Services AG
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Rapamycin, sirolimus
Children's Hospital Medical Center, Cincinnati
2002 Phase 2 NCT00457808 United States
Resveratrol
University of Cincinnati
2018 Phase 2 NCT03253913 United States
Saracatinib
Baylor College of Medicine
2016 Phase 2 NCT02737202 United States
Tony Eissa
2014 Phase 1 NCT02116712 United States
Simvastatin
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Sirolimus
Cardiff University
2005 Phase 2 NCT00490789 United Kingdom
Kobe University Graduate School of Medicine
2012 - JPRN-UMIN000007387 Japan
Koh Nakata, MD, Ph.D
2011 Phase 2 JPRN-jRCT1091220037 Japan
Koh Nakata, MD, PhD
2012 Phase 2 JPRN-jRCT2091220096 Japan
Office of Rare Diseases (ORD)
2006 Phase 3 NCT00414648 Canada;Japan;United States
University of Cincinnati
2018 Phase 2 NCT03253913 United States
2018 Phase 3 NCT03150914 United States
2015 - NCT02432560 United States
Sirolimus 2MG
Frank McCormack, M.D., University of Cincinnati Medical Center Director, Division of Pulmonary and Critical Care Medicine
2008 Phase 3 JPRN-jRCT2091220011 Canada;Japan;United States
National Heart, Lung, and Blood Institute (NHLBI)
2017 Phase 2 NCT03304678 United States
National Hospital Organization Kinki-chuo Chest Medical Center
2015 - JPRN-UMIN000016677 Japan
Sirolimus and hydroxychloroquine 200 MG
Brigham and Women's Hospital
2012 Phase 1 NCT01687179 United States
Sirolimus and hydroxychloroquine 400 MG
Brigham and Women's Hospital
2012 Phase 1 NCT01687179 United States
Sirolimus oral product
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Temsirolimus
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Valproic acid
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Peking Union Medical College Hospital
2019 Phase 1 NCT04273334 China
Acetate
Brigham and Women's Hospital
2021 Phase 1/Phase 2 NCT05467397 United States
Afinitor
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Afinitor 5MG tablets
Novartis Pharma Services AG
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Albuterol inhaler
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Albuterol nebulizer
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Assessment OF arterial stiffness using THE vasera VS-1500N
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
Bevacizumab
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Breath test using THE compact PTR-TOF-MS
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
Buccal (cheek) swab
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Celecoxib
Brigham and Women's Hospital
2016 Phase 2 NCT02484664 United States
Cetuximab
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Doxycycline
University of Nottingham
2009 Phase 4 NCT00989742 United Kingdom
Doxycycline 100 MG capsules
University of Nottingham
2008 - EUCTR2007-003745-32-GB United Kingdom
Everolimus
Children's Hospital Medical Center, Cincinnati
2008 Phase 1/Phase 2 NCT00792766 United States
NOVARTIS FARMA
2010 - EUCTR2010-019825-32-IT France;Italy
2009 - EUCTR2008-002113-48-IT France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
2010 - EUCTR2008-002113-48-NL France;Germany;Italy;Netherlands;Spain;United Kingdom
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
2009 Phase 3 EUCTR2008-002113-48-FR France;Germany;Italy;Netherlands;Spain;United Kingdom
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Novartis Pharmaceuticals
2010 Phase 2 NCT01059318 France;Germany;Italy;United States
2009 Phase 3 NCT00790400 Canada;France;Germany;Italy;Japan;Netherlands;Poland;Russian Federation;Spain;United Kingdom;United States
University of Cincinnati
2015 - NCT02432560 United States
Everolimus oral product
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Glutamine
Vanderbilt University Medical Center
2019 Phase 1 NCT04388371 United States
Imatimib mesylate
Columbia University
2025 Phase 1 NCT06889168 United States
Imatinib mesylate 400MG capsule
Medical University of South Carolina
2018 Phase 1/Phase 2 NCT03131999 United States
Laboratory biomarker analysis
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Letrozole
University of Cincinnati
2011 Phase 2 NCT01353209 United States
Loratadina stada 10 MG
IDIBELL (Institut d’Investigació Biomédica de Bellvitge)
2021 Phase 2 EUCTR2020-000702-29-ES Spain
Loratadine
IDIBELL (Institut d’Investigació Biomédica de Bellvitge)
2021 Phase 2 EUCTR2020-000702-29-ES Spain
Nintedanib
IRCCS Multimedica
2016 Phase 2 NCT03062943 Italy
Octreotide
National Heart, Lung, and Blood Institute (NHLBI)
2000 Phase 2 NCT00005906 United States
Ofev
MULTIMEDICA S.P.A.
2016 Phase 3 EUCTR2015-004919-20-IT Italy
PFT
National Heart, Lung, and Blood Institute (NHLBI)
2013 Phase 1/Phase 2 NCT01799538 United States
Pharmacological study
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Phlebotomy
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Portable cardiac monitor cardioqvark
I.M. Sechenov First Moscow State Medical University
2023 - NCT05727852 Russian Federation
RAD001
Children's Hospital Medical Center, Cincinnati
2008 Phase 1/Phase 2 NCT00792766 United States
2005 Phase 1/Phase 2 NCT00457964 United States
NOVARTIS FARMA
2010 - EUCTR2010-019825-32-IT France;Italy
2009 - EUCTR2008-002113-48-IT France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharma Service AG
2010 - EUCTR2010-019825-32-FR France;Italy
Novartis Pharma Services AG
2010 - EUCTR2008-002113-48-NL France;Germany;Italy;Netherlands;Spain;United Kingdom
2009 Phase 3 EUCTR2008-002113-48-GB Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
2009 Phase 3 EUCTR2008-002113-48-FR France;Germany;Italy;Netherlands;Spain;United Kingdom
Novartis Pharmaceuticals
2009 Phase 3 NCT00790400 Canada;France;Germany;Italy;Japan;Netherlands;Poland;Russian Federation;Spain;United Kingdom;United States
RAD001 5MG
Novartis Pharma Services AG
- Phase 3 EUCTR2008-002113-48-DE Canada;France;Germany;Italy;Japan;Netherlands;Russian Federation;Spain;United Kingdom;United States
Rapamycin, sirolimus
Children's Hospital Medical Center, Cincinnati
2002 Phase 2 NCT00457808 United States
Resveratrol
University of Cincinnati
2018 Phase 2 NCT03253913 United States
Saracatinib
Baylor College of Medicine
2016 Phase 2 NCT02737202 United States
Tony Eissa
2014 Phase 1 NCT02116712 United States
Simvastatin
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Sirolimus
Cardiff University
2005 Phase 2 NCT00490789 United Kingdom
Kobe University Graduate School of Medicine
2012 - JPRN-UMIN000007387 Japan
Koh Nakata, MD, Ph.D
2011 Phase 2 JPRN-jRCT1091220037 Japan
Koh Nakata, MD, PhD
2012 Phase 2 JPRN-jRCT2091220096 Japan
Office of Rare Diseases (ORD)
2006 Phase 3 NCT00414648 Canada;Japan;United States
University of Cincinnati
2018 Phase 2 NCT03253913 United States
2018 Phase 3 NCT03150914 United States
2015 - NCT02432560 United States
Sirolimus 2MG
Frank McCormack, M.D., University of Cincinnati Medical Center Director, Division of Pulmonary and Critical Care Medicine
2008 Phase 3 JPRN-jRCT2091220011 Canada;Japan;United States
National Heart, Lung, and Blood Institute (NHLBI)
2017 Phase 2 NCT03304678 United States
National Hospital Organization Kinki-chuo Chest Medical Center
2015 - JPRN-UMIN000016677 Japan
Sirolimus and hydroxychloroquine 200 MG
Brigham and Women's Hospital
2012 Phase 1 NCT01687179 United States
Sirolimus and hydroxychloroquine 400 MG
Brigham and Women's Hospital
2012 Phase 1 NCT01687179 United States
Sirolimus oral product
University of Pennsylvania
2014 Phase 1/Phase 2 NCT02061397 United States
Temsirolimus
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States
Tissue donation after routine clinical procedure
National Tuberous Sclerosis Association
2016 - NCT05676099 Canada;United States
Valproic acid
M.D. Anderson Cancer Center
2012 Phase 1 NCT01552434 United States