| 1 | Leflunomide-sulfasalazine-hydroxychloroquine | Hydroxychloroquine | [3] D00448D00448, D00749D00749, D08050D08050 💬 | DHODH[1] DHODH 💬 | Biosynthesis of cofactors[3] Biosynthesis of cofactors, Metabolic pathways, Pyrimidine metabolism | 046[1] 46 💬 | 
| 2 | Methotrexate plus sulfasalazine | Methotrexate | [3] D00142D00142, D00448D00448, D02115D02115 💬 | DHFR[2] DHFR, DHFR2 💬 | Antifolate resistance[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate | 046[1] 46 💬 | 
| 3 | Methotrexate-sulfasalazine-hydroxychloroquine | Hydroxychloroquine | [4] D00142D00142, D00448D00448, D02115D02115, D08050D08050 💬 | DHFR[2] DHFR, DHFR2 💬 | Antifolate resistance[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate | 046[1] 46 💬 | 
| 4 | Nsaids and sulfasalazine | Sulfasalazine | [1] D00448D00448 💬 | - | - | 271[1] 271 💬 | 
| 5 | Sulfasalazine | Sulfasalazine | [1] D00448D00448 💬 | - | - | 046[4] 46, 86, 94, 271 💬 | 
| 6 | Sulfasalazine, ssz | Sulfasalazine | [1] D00448D00448 💬 | - | - | 271[1] 271 💬 |