Target Gene/Pathway💬 Info on mouse-over

No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	African trypanosomiasis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
2	African trypanosomiasis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
3	AGE-RAGE signaling pathway in diabetic complications 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
4	AGE-RAGE signaling pathway in diabetic complications 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
5	Alzheimer disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
6	Alzheimer disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
7	Amoebiasis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
8	Amoebiasis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
9	Amoebiasis 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
10	Antifolate resistance 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
11	Antifolate resistance 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
12	C-type lectin receptor signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
13	C-type lectin receptor signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
14	Cellular senescence 💬	[1] IL1A 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
15	Chagas disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
16	Chagas disease 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
17	Coronavirus disease - COVID-19 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
18	Coronavirus disease - COVID-19 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
19	Cytokine-cytokine receptor interaction 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
20	Cytokine-cytokine receptor interaction 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
21	Cytokine-cytokine receptor interaction 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
22	Cytosolic DNA-sensing pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
23	Cytosolic DNA-sensing pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
24	Fluid shear stress and atherosclerosis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
25	Fluid shear stress and atherosclerosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
26	Fluid shear stress and atherosclerosis 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
27	Graft-versus-host disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
28	Graft-versus-host disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
29	Hematopoietic cell lineage 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
30	Hematopoietic cell lineage 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
31	Hematopoietic cell lineage 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
32	Herpes simplex virus 1 infection 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
33	Herpes simplex virus 1 infection 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
34	Human cytomegalovirus infection 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
35	Human cytomegalovirus infection 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
36	Human cytomegalovirus infection 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
37	Human T-cell leukemia virus 1 infection 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
38	IL-17 signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
39	IL-17 signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
40	Inflammatory bowel disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
41	Inflammatory bowel disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
42	Inflammatory mediator regulation of TRP channels 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
43	Inflammatory mediator regulation of TRP channels 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
44	Inflammatory mediator regulation of TRP channels 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
45	Influenza A 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
46	Influenza A 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
47	Legionellosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
48	Legionellosis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
49	Leishmaniasis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
50	Leishmaniasis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
51	Malaria 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
52	Malaria 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
53	MAPK signaling pathway 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
54	MAPK signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
55	MAPK signaling pathway 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
56	Measles 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
57	Measles 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
58	Necroptosis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
59	Necroptosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
60	NF-kappa B signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
61	NF-kappa B signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
62	NF-kappa B signaling pathway 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
63	NOD-like receptor signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
64	NOD-like receptor signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
65	Non-alcoholic fatty liver disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
66	Non-alcoholic fatty liver disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
67	Osteoclast differentiation 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
68	Osteoclast differentiation 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
69	Osteoclast differentiation 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
70	Pathogenic Escherichia coli infection 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
71	Pathogenic Escherichia coli infection 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
72	Pathogenic Escherichia coli infection 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
73	Pathways of neurodegeneration - multiple diseases 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
74	Pathways of neurodegeneration - multiple diseases 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
75	Pertussis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
76	Pertussis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
77	Prion disease 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
78	Prion disease 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
79	Prostate cancer 💬	[1] IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
80	Rheumatoid arthritis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
81	Rheumatoid arthritis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
82	Salmonella infection 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
83	Salmonella infection 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
84	Shigellosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
85	Shigellosis 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
86	Shigellosis 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
87	Th17 cell differentiation 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
88	Th17 cell differentiation 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
89	Th17 cell differentiation 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
90	TNF signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
91	TNF signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
92	Toll-like receptor signaling pathway 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
93	Toll-like receptor signaling pathway 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
94	Transcriptional misregulation in cancer 💬	[1] IL1R2 💬	D02934 💬	Anakinra	[19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
95	Tuberculosis 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
96	Tuberculosis 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
97	Type I diabetes mellitus 💬	[2] IL1A, IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬
98	Type I diabetes mellitus 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
99	Yersinia infection 💬	[1] IL1B 💬	D09315 💬	Canakinumab	[10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
100	Yersinia infection 💬	[1] IL1B 💬	D06635 💬	Rilonacept	[4] 51, 106, 107, 266 💬

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