DDrare: Database of Drug Development for Rare Diseases

Target Gene/Pathway💬 Info on mouse-over

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162 / 286 pathways

No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	ABC transporters 💬	[1] ABCC8 💬	D00594 💬	Repaglinide	[3] 6 , 21, 299 💬
2	ABC transporters 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
3	ABC transporters 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
4	ABC transporters 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
5	ABC transporters 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
6	ABC transporters 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
7	ABC transporters 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
8	Acute myeloid leukemia 💬	[1] RARA 💬	D04162 💬	Fenretinide	[1] 299 💬
9	Adherens junction 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
10	Adherens junction 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
11	Adherens junction 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
12	Adherens junction 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
13	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
14	Adipocytokine signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
15	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
16	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
17	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
18	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
19	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
20	Adrenergic signaling in cardiomyocytes 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
21	Adrenergic signaling in cardiomyocytes 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
22	Adrenergic signaling in cardiomyocytes 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
23	Adrenergic signaling in cardiomyocytes 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
24	AGE-RAGE signaling pathway in diabetic complications 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
25	AGE-RAGE signaling pathway in diabetic complications 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26	Alcoholism 💬	[1] ADORA2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
27	Alcoholism 💬	[1] ADORA2B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
28	Alcoholism 💬	[1] ADORA2B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
29	Alcoholism 💬	[1] ADORA2B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
30	Alcoholism 💬	[1] ADORA2B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
31	Aldosterone synthesis and secretion 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
32	Aldosterone synthesis and secretion 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
33	Aldosterone synthesis and secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
34	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D00371 💬	Theophylline	[2] 236, 299 💬
35	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D01712 💬	Theophylline	[2] 236, 299 💬
36	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
37	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D06103 💬	Theophylline	[2] 236, 299 💬
38	Aldosterone synthesis and secretion 💬	[1] PDE2A 💬	D06104 💬	Theophylline	[2] 236, 299 💬
39	Aldosterone-regulated sodium reabsorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
40	Aldosterone-regulated sodium reabsorption 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
41	Aldosterone-regulated sodium reabsorption 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
42	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D00649 💬	Amiloride	[3] 13, 225, 299 💬
43	Aldosterone-regulated sodium reabsorption 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D07447 💬	Amiloride	[3] 13, 225, 299 💬
44	Alzheimer disease 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
45	Alzheimer disease 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
46	Alzheimer disease 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
47	Alzheimer disease 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
48	Alzheimer disease 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
49	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
50	Alzheimer disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
51	Alzheimer disease 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
52	Alzheimer disease 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
53	Alzheimer disease 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
54	Alzheimer disease 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
55	Amoebiasis 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
56	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
57	Amphetamine addiction 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
58	AMPK signaling pathway 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
59	AMPK signaling pathway 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
60	AMPK signaling pathway 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
61	AMPK signaling pathway 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
62	AMPK signaling pathway 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
63	AMPK signaling pathway 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
64	AMPK signaling pathway 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
65	AMPK signaling pathway 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
66	AMPK signaling pathway 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
67	AMPK signaling pathway 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
68	AMPK signaling pathway 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
69	AMPK signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
70	AMPK signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
71	AMPK signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
72	AMPK signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
73	AMPK signaling pathway 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
74	AMPK signaling pathway 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
75	AMPK signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
76	AMPK signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
77	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
78	Amyotrophic lateral sclerosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
79	Apelin signaling pathway 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
80	Apelin signaling pathway 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
81	Apelin signaling pathway 💬	[1] PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
82	Apelin signaling pathway 💬	[1] PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
83	Apelin signaling pathway 💬	[1] PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
84	Apelin signaling pathway 💬	[1] PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
85	Apelin signaling pathway 💬	[1] PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
86	Apelin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
87	Apelin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
88	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
89	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
90	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
91	Arachidonic acid metabolism 💬	[2] PTGS1, PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
92	Asthma 💬	[1] FCER1A 💬	D05251 💬	Omalizumab	[7] 46, 53, 65, 98, 162, 226, 299 💬
93	Autophagy - animal 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
94	Autophagy - animal 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
95	Autophagy - animal 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
96	Autophagy - animal 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
97	Axon guidance 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
98	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
99	Axon guidance 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
100	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
101	B cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
102	Bile secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
103	Bile secretion 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
104	Bile secretion 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
105	Bile secretion 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
106	Bile secretion 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
107	Bile secretion 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
108	Bile secretion 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
109	Bile secretion 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
110	Bile secretion 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
111	Bile secretion 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
112	Bile secretion 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
113	Bile secretion 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
114	Bile secretion 💬	[1] NR1H4 💬	D00734 💬	Ursodeoxycholic acid	[13] 6 , 8 , 20, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
115	Breast cancer 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
116	Breast cancer 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
117	Breast cancer 💬	[2] ESR1, ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
118	Breast cancer 💬	[2] ESR1, ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
119	Breast cancer 💬	[2] ESR1, ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
120	Breast cancer 💬	[2] ESR1, ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
121	Breast cancer 💬	[2] ESR1, ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
122	Breast cancer 💬	[2] ESR1, ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
123	Breast cancer 💬	[2] ESR1, ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
124	Breast cancer 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
125	Breast cancer 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
126	Breast cancer 💬	[1] PGR 💬	D00182 💬	Norethisterone	[4] 13, 46, 49, 299 💬
127	Breast cancer 💬	[1] PGR 💬	D00953 💬	Norethisterone	[4] 13, 46, 49, 299 💬
128	Breast cancer 💬	[1] PGR 💬	D05209 💬	Norgestimate	[1] 299 💬
129	Breast cancer 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
130	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
131	C-type lectin receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
132	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
133	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
134	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
135	C-type lectin receptor signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
136	Calcium signaling pathway 💬	[4] ADORA2A, PDE1A, PDE1B, PDE1C 💬	D02017 💬	Theophylline	[2] 236, 299 💬
137	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬	D00371 💬	Theophylline	[2] 236, 299 💬
138	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬	D01712 💬	Theophylline	[2] 236, 299 💬
139	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬	D06103 💬	Theophylline	[2] 236, 299 💬
140	Calcium signaling pathway 💬	[4] ADORA2B, PDE1A, PDE1B, PDE1C 💬	D06104 💬	Theophylline	[2] 236, 299 💬
141	Calcium signaling pathway 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
142	Calcium signaling pathway 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
143	Calcium signaling pathway 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
144	Calcium signaling pathway 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
145	Calcium signaling pathway 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
146	Calcium signaling pathway 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
147	Calcium signaling pathway 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
148	Calcium signaling pathway 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
149	Calcium signaling pathway 💬	[2] CHRM2, CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
150	Calcium signaling pathway 💬	[2] CHRM2, CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
151	Calcium signaling pathway 💬	[2] CHRM2, CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
152	Calcium signaling pathway 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
153	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
154	Calcium signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
155	Calcium signaling pathway 💬	[1] PTGFR 💬	D06274 💬	Tafluprost	[1] 299 💬
156	cAMP signaling pathway 💬	[9] ADORA1, ADORA2A, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D02017 💬	Theophylline	[2] 236, 299 💬
157	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D00371 💬	Theophylline	[2] 236, 299 💬
158	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D01712 💬	Theophylline	[2] 236, 299 💬
159	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D06103 💬	Theophylline	[2] 236, 299 💬
160	cAMP signaling pathway 💬	[8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬	D06104 💬	Theophylline	[2] 236, 299 💬
161	cAMP signaling pathway 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
162	cAMP signaling pathway 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
163	cAMP signaling pathway 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
164	cAMP signaling pathway 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
165	cAMP signaling pathway 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
166	cAMP signaling pathway 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
167	cAMP signaling pathway 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
168	cAMP signaling pathway 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
169	cAMP signaling pathway 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
170	cAMP signaling pathway 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
171	cAMP signaling pathway 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
172	cAMP signaling pathway 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
173	cAMP signaling pathway 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
174	cAMP signaling pathway 💬	[1] CHRM2 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
175	cAMP signaling pathway 💬	[1] CHRM2 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
176	cAMP signaling pathway 💬	[1] CHRM2 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
177	cAMP signaling pathway 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D05744 💬	Roflumilast	[2] 84, 299 💬
178	Carbohydrate digestion and absorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
179	Cardiac muscle contraction 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
180	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
181	Cellular senescence 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
182	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
183	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
184	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
185	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
186	cGMP-PKG signaling pathway 💬	[4] ADORA1, PDE2A, PDE3A, PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
187	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
188	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
189	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
190	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
191	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
192	cGMP-PKG signaling pathway 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
193	cGMP-PKG signaling pathway 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
194	cGMP-PKG signaling pathway 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
195	cGMP-PKG signaling pathway 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
196	cGMP-PKG signaling pathway 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
197	cGMP-PKG signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
198	cGMP-PKG signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
199	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D02229 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
200	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D08514 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
201	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D02731 💬	Vardenafil	[3] 13, 86, 299 💬
202	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D03260 💬	Vardenafil	[3] 13, 86, 299 💬
203	cGMP-PKG signaling pathway 💬	[1] PDE5A 💬	D08668 💬	Vardenafil	[3] 13, 86, 299 💬
204	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
205	cGMP-PKG signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
206	Chagas disease 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
207	Chemical carcinogenesis 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
208	Chemical carcinogenesis 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
209	Chemical carcinogenesis 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
210	Chemical carcinogenesis 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
211	Chemokine signaling pathway 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
212	Chemokine signaling pathway 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
213	Cholinergic synapse 💬	[1] ACHE 💬	D02068 💬	Tacrine	[3] 46, 271, 299 💬
214	Cholinergic synapse 💬	[1] ACHE 💬	D08555 💬	Tacrine	[3] 46, 271, 299 💬
215	Cholinergic synapse 💬	[2] CHRM2, CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
216	Cholinergic synapse 💬	[2] CHRM2, CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
217	Cholinergic synapse 💬	[2] CHRM2, CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
218	Circadian entrainment 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
219	Circadian rhythm 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
220	Circadian rhythm 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
221	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D01984 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
222	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D04056 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
223	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D07917 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
224	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D09339 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
225	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D00355 💬	Lansoprazole	[7] 63, 71, 85, 98, 166, 222, 299 💬
226	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D00455 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
227	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D01207 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
228	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D05259 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
229	Collecting duct acid secretion 💬	[2] ATP4A, ATP4B 💬	D05261 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
230	Complement and coagulation cascades 💬	[1] SERPINC1 💬	D07510 💬	Heparin	[11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬
231	Coronavirus disease - COVID-19 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
232	Coronavirus disease - COVID-19 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
233	Cortisol synthesis and secretion 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
234	Cortisol synthesis and secretion 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
235	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
236	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
237	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
238	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
239	Cortisol synthesis and secretion 💬	[2] PDE8A, PDE8B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
240	Cushing syndrome 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
241	Cushing syndrome 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
242	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
243	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
244	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
245	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
246	Cushing syndrome 💬	[3] PDE11A, PDE8A, PDE8B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
247	Cytokine-cytokine receptor interaction 💬	[1] CSF2RA 💬	D05066 💬	Molgramostim	[2] 229, 299 💬
248	Cytokine-cytokine receptor interaction 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
249	Cytokine-cytokine receptor interaction 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
250	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
251	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
252	Cytokine-cytokine receptor interaction 💬	[1] GHR 💬	D02691 💬	Somatotropin	[20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
253	Cytokine-cytokine receptor interaction 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
254	Cytokine-cytokine receptor interaction 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
255	Cytokine-cytokine receptor interaction 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
256	Diabetic cardiomyopathy 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
257	Diabetic cardiomyopathy 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
258	Diabetic cardiomyopathy 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
259	Diabetic cardiomyopathy 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
260	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
261	Dopaminergic synapse 💬	[3] PPP3CA, PPP3CB, PPP3CC 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
262	EGFR tyrosine kinase inhibitor resistance 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
263	EGFR tyrosine kinase inhibitor resistance 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
264	Endocrine and other factor-regulated calcium reabsorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
265	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
266	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
267	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
268	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
269	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
270	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
271	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
272	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
273	Endocrine and other factor-regulated calcium reabsorption 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
274	Endocrine and other factor-regulated calcium reabsorption 💬	[1] VDR 💬	D00122 💬	Calcifediol	[2] 113, 299 💬
275	Endocrine and other factor-regulated calcium reabsorption 💬	[1] VDR 💬	D00188 💬	Cholecalciferol	[23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬
276	Endocrine and other factor-regulated calcium reabsorption 💬	[1] VDR 💬	D00187 💬	Ergocalciferol	[5] 46, 84, 96, 97, 299 💬
277	Endocrine resistance 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
278	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
279	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
280	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
281	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
282	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
283	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
284	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
285	Endocrine resistance 💬	[2] ESR1, ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
286	Endocrine resistance 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
287	Endocrine resistance 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
288	Endocytosis 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
289	Endocytosis 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
290	Endocytosis 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
291	Endocytosis 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
292	Epithelial cell signaling in Helicobacter pylori infection 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
293	Estrogen signaling pathway 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
294	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
295	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
296	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
297	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
298	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
299	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
300	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
301	Estrogen signaling pathway 💬	[2] ESR1, ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
302	Estrogen signaling pathway 💬	[1] PGR 💬	D00182 💬	Norethisterone	[4] 13, 46, 49, 299 💬
303	Estrogen signaling pathway 💬	[1] PGR 💬	D00953 💬	Norethisterone	[4] 13, 46, 49, 299 💬
304	Estrogen signaling pathway 💬	[1] PGR 💬	D05209 💬	Norgestimate	[1] 299 💬
305	Estrogen signaling pathway 💬	[1] RARA 💬	D04162 💬	Fenretinide	[1] 299 💬
306	Fc epsilon RI signaling pathway 💬	[1] FCER1A 💬	D05251 💬	Omalizumab	[7] 46, 53, 65, 98, 162, 226, 299 💬
307	Fluid shear stress and atherosclerosis 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
308	Fluid shear stress and atherosclerosis 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
309	Fluid shear stress and atherosclerosis 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
310	Focal adhesion 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
311	Focal adhesion 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
312	FoxO signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
313	FoxO signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
314	FoxO signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
315	FoxO signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
316	FoxO signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
317	FoxO signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
318	Gap junction 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
319	Gastric acid secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
320	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D01984 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
321	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D04056 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
322	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D07917 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
323	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D09339 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
324	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D00355 💬	Lansoprazole	[7] 63, 71, 85, 98, 166, 222, 299 💬
325	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D00455 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
326	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D01207 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
327	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D05259 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
328	Gastric acid secretion 💬	[2] ATP4A, ATP4B 💬	D05261 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
329	Gastric acid secretion 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
330	Gastric acid secretion 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
331	Gastric acid secretion 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
332	Gastric acid secretion 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
333	Gastric acid secretion 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
334	Gastric acid secretion 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
335	Gastric acid secretion 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
336	Gastric acid secretion 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
337	Gastric acid secretion 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
338	Gastric cancer 💬	[1] RARB 💬	D04162 💬	Fenretinide	[1] 299 💬
339	Glioma 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
340	Glioma 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
341	Glucagon signaling pathway 💬	[1] PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
342	Glucagon signaling pathway 💬	[1] PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
343	Glucagon signaling pathway 💬	[1] PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
344	Glucagon signaling pathway 💬	[1] PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
345	Glucagon signaling pathway 💬	[1] PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
346	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
347	Glucagon signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
348	Glucagon signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
349	Glucagon signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
350	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
351	Glutamatergic synapse 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
352	Glycerophospholipid metabolism 💬	[1] ACHE 💬	D02068 💬	Tacrine	[3] 46, 271, 299 💬
353	Glycerophospholipid metabolism 💬	[1] ACHE 💬	D08555 💬	Tacrine	[3] 46, 271, 299 💬
354	GnRH secretion 💬	[1] ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
355	GnRH secretion 💬	[1] ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
356	GnRH secretion 💬	[1] ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
357	GnRH secretion 💬	[1] ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
358	GnRH secretion 💬	[1] ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
359	GnRH secretion 💬	[1] ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
360	GnRH secretion 💬	[1] ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
361	GnRH secretion 💬	[1] ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
362	GnRH secretion 💬	[1] KCNJ11 💬	D00594 💬	Repaglinide	[3] 6 , 21, 299 💬
363	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
364	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
365	Growth hormone synthesis, secretion and action 💬	[1] GHR 💬	D02691 💬	Somatotropin	[20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
366	Hematopoietic cell lineage 💬	[1] CSF2RA 💬	D05066 💬	Molgramostim	[2] 229, 299 💬
367	Hematopoietic cell lineage 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
368	Hepatocellular carcinoma 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
369	Hepatocellular carcinoma 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
370	Herpes simplex virus 1 infection 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
371	HIF-1 signaling pathway 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
372	HIF-1 signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
373	HIF-1 signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
374	HIF-1 signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
375	HIF-1 signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
376	Human cytomegalovirus infection 💬	[1] CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
377	Human cytomegalovirus infection 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
378	Human cytomegalovirus infection 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
379	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
380	Human cytomegalovirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
381	Human cytomegalovirus infection 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
382	Human cytomegalovirus infection 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
383	Human cytomegalovirus infection 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
384	Human cytomegalovirus infection 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
385	Human immunodeficiency virus 1 infection 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
386	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
387	Human immunodeficiency virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
388	Human papillomavirus infection 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
389	Human papillomavirus infection 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
390	Human papillomavirus infection 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
391	Human papillomavirus infection 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
392	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D00939 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
393	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D07119 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
394	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D01968 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
395	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D06378 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
396	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D06379 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
397	Human T-cell leukemia virus 1 infection 💬	[1] FDPS 💬	D08689 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
398	Human T-cell leukemia virus 1 infection 💬	[2] IL1R1, IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
399	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
400	Human T-cell leukemia virus 1 infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
401	Huntington disease 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
402	Huntington disease 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
403	Hypertrophic cardiomyopathy 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
404	Hypertrophic cardiomyopathy 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
405	IL-17 signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
406	IL-17 signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
407	IL-17 signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
408	IL-17 signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
409	Inflammatory bowel disease 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
410	Inflammatory mediator regulation of TRP channels 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
411	Influenza A 💬	[1] FDPS 💬	D00939 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
412	Influenza A 💬	[1] FDPS 💬	D07119 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
413	Influenza A 💬	[1] FDPS 💬	D01968 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
414	Influenza A 💬	[1] FDPS 💬	D06378 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
415	Influenza A 💬	[1] FDPS 💬	D06379 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
416	Influenza A 💬	[1] FDPS 💬	D08689 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
417	Influenza A 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
418	Insulin resistance 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
419	Insulin resistance 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
420	Insulin resistance 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
421	Insulin resistance 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
422	Insulin secretion 💬	[2] ABCC8, KCNJ11 💬	D00594 💬	Repaglinide	[3] 6 , 21, 299 💬
423	Insulin secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
424	Insulin secretion 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
425	Insulin secretion 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
426	Insulin secretion 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
427	Insulin signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
428	Insulin signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
429	Insulin signaling pathway 💬	[1] PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
430	Insulin signaling pathway 💬	[1] PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
431	Insulin signaling pathway 💬	[1] PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
432	Insulin signaling pathway 💬	[1] PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
433	Insulin signaling pathway 💬	[1] PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
434	Insulin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
435	Insulin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
436	Intestinal immune network for IgA production 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
437	JAK-STAT signaling pathway 💬	[1] CSF2RA 💬	D05066 💬	Molgramostim	[2] 229, 299 💬
438	JAK-STAT signaling pathway 💬	[1] GHR 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
439	JAK-STAT signaling pathway 💬	[1] GHR 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
440	JAK-STAT signaling pathway 💬	[1] GHR 💬	D02691 💬	Somatotropin	[20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
441	JAK-STAT signaling pathway 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
442	Kaposi sarcoma-associated herpesvirus infection 💬	[1] IFNGR1 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
443	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
444	Kaposi sarcoma-associated herpesvirus infection 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
445	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
446	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
447	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
448	Kaposi sarcoma-associated herpesvirus infection 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
449	Leishmaniasis 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
450	Leishmaniasis 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
451	Leishmaniasis 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
452	Leishmaniasis 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
453	Leishmaniasis 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
454	Leukocyte transendothelial migration 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
455	Long-term depression 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
456	Long-term depression 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
457	Long-term depression 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
458	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
459	Long-term potentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
460	Longevity regulating pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
461	Longevity regulating pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
462	Longevity regulating pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
463	Longevity regulating pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
464	Longevity regulating pathway 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
465	Longevity regulating pathway 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
466	Longevity regulating pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
467	Longevity regulating pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
468	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
469	Longevity regulating pathway - multiple species 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
470	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
471	Longevity regulating pathway - multiple species 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
472	Longevity regulating pathway - multiple species 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
473	Longevity regulating pathway - multiple species 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
474	MAPK signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
475	MAPK signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
476	MAPK signaling pathway 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
477	MAPK signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
478	MAPK signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
479	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
480	MAPK signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
481	Melanoma 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
482	Melanoma 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
483	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D01984 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
484	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D04056 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
485	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D07917 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
486	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D09339 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
487	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D00355 💬	Lansoprazole	[7] 63, 71, 85, 98, 166, 222, 299 💬
488	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D00455 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
489	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D01207 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
490	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D05259 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
491	Metabolic pathways 💬	[2] ATP4A, ATP4B 💬	D05261 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
492	Metabolic pathways 💬	[1] FDPS 💬	D00939 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
493	Metabolic pathways 💬	[1] FDPS 💬	D07119 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
494	Metabolic pathways 💬	[1] FDPS 💬	D01968 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
495	Metabolic pathways 💬	[1] FDPS 💬	D06378 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
496	Metabolic pathways 💬	[1] FDPS 💬	D06379 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
497	Metabolic pathways 💬	[1] FDPS 💬	D08689 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
498	Metabolic pathways 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
499	Metabolic pathways 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
500	Metabolic pathways 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
501	Metabolic pathways 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
502	Metabolic pathways 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
503	Metabolic pathways 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
504	Metabolic pathways 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
505	Metabolic pathways 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
506	Metabolic pathways 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
507	Metabolic pathways 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
508	Metabolic pathways 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
509	Metabolic pathways 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D05744 💬	Roflumilast	[2] 84, 299 💬
510	Metabolic pathways 💬	[1] PDE5A 💬	D02229 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
511	Metabolic pathways 💬	[1] PDE5A 💬	D08514 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
512	Metabolic pathways 💬	[1] PDE5A 💬	D02731 💬	Vardenafil	[3] 13, 86, 299 💬
513	Metabolic pathways 💬	[1] PDE5A 💬	D03260 💬	Vardenafil	[3] 13, 86, 299 💬
514	Metabolic pathways 💬	[1] PDE5A 💬	D08668 💬	Vardenafil	[3] 13, 86, 299 💬
515	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
516	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
517	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
518	Metabolic pathways 💬	[2] PTGS1, PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
519	Metabolic pathways 💬	[1] UGCG 💬	D05032 💬	Miglustat	[3] 19, 256, 299 💬
520	MicroRNAs in cancer 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
521	MicroRNAs in cancer 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
522	MicroRNAs in cancer 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
523	MicroRNAs in cancer 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
524	Mineral absorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
525	Mineral absorption 💬	[1] CLCN2 💬	D04790 💬	Lubiprostone	[4] 6 , 13, 290, 299 💬
526	Mineral absorption 💬	[1] VDR 💬	D00122 💬	Calcifediol	[2] 113, 299 💬
527	Mineral absorption 💬	[1] VDR 💬	D00188 💬	Cholecalciferol	[23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬
528	Mineral absorption 💬	[1] VDR 💬	D00187 💬	Ergocalciferol	[5] 46, 84, 96, 97, 299 💬
529	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
530	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
531	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
532	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
533	Morphine addiction 💬	[17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
534	Morphine addiction 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D05744 💬	Roflumilast	[2] 84, 299 💬
535	mTOR signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
536	mTOR signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
537	mTOR signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
538	mTOR signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
539	mTOR signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
540	mTOR signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
541	Natural killer cell mediated cytotoxicity 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
542	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
543	Natural killer cell mediated cytotoxicity 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
544	Necroptosis 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
545	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
546	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
547	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
548	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
549	Neuroactive ligand-receptor interaction 💬	[2] ADORA1, ADORA2B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
550	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
551	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
552	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
553	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
554	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
555	Neuroactive ligand-receptor interaction 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
556	Neuroactive ligand-receptor interaction 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
557	Neuroactive ligand-receptor interaction 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
558	Neuroactive ligand-receptor interaction 💬	[2] CHRM2, CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
559	Neuroactive ligand-receptor interaction 💬	[2] CHRM2, CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
560	Neuroactive ligand-receptor interaction 💬	[2] CHRM2, CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
561	Neuroactive ligand-receptor interaction 💬	[1] CNR2 💬	D11312 💬	Ajulemic acid	[3] 50, 51, 299 💬
562	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
563	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
564	Neuroactive ligand-receptor interaction 💬	[1] GHR 💬	D02691 💬	Somatotropin	[20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
565	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00246 💬	Budesonide	[9] 66, 93, 94, 95, 96, 97, 98, 228, 299 💬
566	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00292 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
567	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00975 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
568	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01510 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
569	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01615 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
570	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01632 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
571	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01948 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
572	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D02174 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
573	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D02591 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
574	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D02592 💬	Dexamethasone	[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
575	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D07981 💬	Fluticasone	[3] 98, 228, 299 💬
576	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00088 💬	Hydrocortisone	[9] 6 , 46, 53, 75, 78, 81, 83, 97, 299 💬
577	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00472 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
578	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00980 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
579	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00981 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
580	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00982 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
581	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01239 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
582	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D01998 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
583	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D02156 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
584	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D03301 💬	Prednisolone	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
585	Neuroactive ligand-receptor interaction 💬	[1] NR3C1 💬	D00473 💬	Prednisone	[47] 2 , 6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
586	Neuroactive ligand-receptor interaction 💬	[1] PTGFR 💬	D06274 💬	Tafluprost	[1] 299 💬
587	NF-kappa B signaling pathway 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
588	NF-kappa B signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
589	NF-kappa B signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
590	NF-kappa B signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
591	NF-kappa B signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
592	NF-kappa B signaling pathway 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
593	Non-alcoholic fatty liver disease 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
594	Non-alcoholic fatty liver disease 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
595	Non-alcoholic fatty liver disease 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
596	Non-alcoholic fatty liver disease 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
597	Non-small cell lung cancer 💬	[1] RARB 💬	D04162 💬	Fenretinide	[1] 299 💬
598	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬	D00371 💬	Theophylline	[2] 236, 299 💬
599	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬	D01712 💬	Theophylline	[2] 236, 299 💬
600	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
601	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬	D06103 💬	Theophylline	[2] 236, 299 💬
602	Olfactory transduction 💬	[4] PDE1A, PDE1B, PDE1C, PDE2A 💬	D06104 💬	Theophylline	[2] 236, 299 💬
603	Oocyte meiosis 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
604	Oocyte meiosis 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
605	Oocyte meiosis 💬	[1] PGR 💬	D00182 💬	Norethisterone	[4] 13, 46, 49, 299 💬
606	Oocyte meiosis 💬	[1] PGR 💬	D00953 💬	Norethisterone	[4] 13, 46, 49, 299 💬
607	Oocyte meiosis 💬	[1] PGR 💬	D05209 💬	Norgestimate	[1] 299 💬
608	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
609	Oocyte meiosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
610	Osteoclast differentiation 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
611	Osteoclast differentiation 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
612	Osteoclast differentiation 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
613	Osteoclast differentiation 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
614	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
615	Osteoclast differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
616	Osteoclast differentiation 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
617	Ovarian steroidogenesis 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
618	Ovarian steroidogenesis 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
619	Ovarian steroidogenesis 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
620	Ovarian steroidogenesis 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
621	Ovarian steroidogenesis 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
622	Ovarian steroidogenesis 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
623	Ovarian steroidogenesis 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
624	Ovarian steroidogenesis 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
625	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D01984 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
626	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D04056 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
627	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D07917 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
628	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D09339 💬	Esomeprazole	[6] 13, 46, 86, 98, 298, 299 💬
629	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D00355 💬	Lansoprazole	[7] 63, 71, 85, 98, 166, 222, 299 💬
630	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D00455 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
631	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D01207 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
632	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D05259 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
633	Oxidative phosphorylation 💬	[2] ATP4A, ATP4B 💬	D05261 💬	Omeprazole	[16] 6 , 8 , 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299 💬
634	Oxytocin signaling pathway 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
635	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
636	Oxytocin signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
637	Oxytocin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
638	Oxytocin signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
639	Oxytocin signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
640	Oxytocin signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
641	Oxytocin signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
642	Oxytocin signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
643	Pancreatic secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
644	Pancreatic secretion 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
645	Pancreatic secretion 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
646	Pancreatic secretion 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
647	Pancreatic secretion 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
648	Pancreatic secretion 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
649	Pancreatic secretion 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
650	Pancreatic secretion 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
651	Pancreatic secretion 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
652	Pancreatic secretion 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
653	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D05744 💬	Roflumilast	[2] 84, 299 💬
654	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D00371 💬	Theophylline	[2] 236, 299 💬
655	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D01712 💬	Theophylline	[2] 236, 299 💬
656	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D02017 💬	Theophylline	[2] 236, 299 💬
657	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D06103 💬	Theophylline	[2] 236, 299 💬
658	Parathyroid hormone synthesis, secretion and action 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D06104 💬	Theophylline	[2] 236, 299 💬
659	Parathyroid hormone synthesis, secretion and action 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
660	Parathyroid hormone synthesis, secretion and action 💬	[1] VDR 💬	D00122 💬	Calcifediol	[2] 113, 299 💬
661	Parathyroid hormone synthesis, secretion and action 💬	[1] VDR 💬	D00188 💬	Cholecalciferol	[23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬
662	Parathyroid hormone synthesis, secretion and action 💬	[1] VDR 💬	D00187 💬	Ergocalciferol	[5] 46, 84, 96, 97, 299 💬
663	Parkinson disease 💬	[1] ADORA2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
664	Pathogenic Escherichia coli infection 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
665	Pathways in cancer 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
666	Pathways in cancer 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
667	Pathways in cancer 💬	[1] CSF2RA 💬	D05066 💬	Molgramostim	[2] 229, 299 💬
668	Pathways in cancer 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
669	Pathways in cancer 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
670	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
671	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
672	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
673	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
674	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
675	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
676	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
677	Pathways in cancer 💬	[2] ESR1, ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
678	Pathways in cancer 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
679	Pathways in cancer 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
680	Pathways in cancer 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
681	Pathways in cancer 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
682	Pathways in cancer 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
683	Pathways in cancer 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
684	Pathways in cancer 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
685	Pathways in cancer 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
686	Pathways in cancer 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
687	Pathways in cancer 💬	[2] RARA, RARB 💬	D04162 💬	Fenretinide	[1] 299 💬
688	Pathways of neurodegeneration - multiple diseases 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
689	Pathways of neurodegeneration - multiple diseases 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
690	Pathways of neurodegeneration - multiple diseases 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
691	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
692	Pathways of neurodegeneration - multiple diseases 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
693	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
694	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
695	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
696	Pathways of neurodegeneration - multiple diseases 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
697	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
698	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
699	PD-L1 expression and PD-1 checkpoint pathway in cancer 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
700	Phospholipase D signaling pathway 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
701	Phospholipase D signaling pathway 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
702	Phospholipase D signaling pathway 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
703	Phospholipase D signaling pathway 💬	[1] FCER1A 💬	D05251 💬	Omalizumab	[7] 46, 53, 65, 98, 162, 226, 299 💬
704	Phospholipase D signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
705	Phospholipase D signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
706	Phospholipase D signaling pathway 💬	[1] PTGFR 💬	D06274 💬	Tafluprost	[1] 299 💬
707	PI3K-Akt signaling pathway 💬	[1] CHRM2 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
708	PI3K-Akt signaling pathway 💬	[1] CHRM2 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
709	PI3K-Akt signaling pathway 💬	[1] CHRM2 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
710	PI3K-Akt signaling pathway 💬	[1] GHR 💬	D02691 💬	Somatotropin	[20] 2 , 3 , 13, 19, 46, 74, 75, 76, 78, 96, 113, 187, 191, 193, 195, 236, 265, 274, 276, 299 💬
711	PI3K-Akt signaling pathway 💬	[2] GHR, IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
712	PI3K-Akt signaling pathway 💬	[2] GHR, IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
713	PI3K-Akt signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
714	PI3K-Akt signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
715	PI3K-Akt signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
716	PI3K-Akt signaling pathway 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
717	Platelet activation 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
718	Platelet activation 💬	[1] PTGS1 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
719	Platelet activation 💬	[1] PTGS1 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
720	Platelet activation 💬	[1] PTGS1 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
721	Platelet activation 💬	[1] PTGS1 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
722	PPAR signaling pathway 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
723	PPAR signaling pathway 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
724	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
725	Prion disease 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
726	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
727	Progesterone-mediated oocyte maturation 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
728	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
729	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
730	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
731	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
732	Progesterone-mediated oocyte maturation 💬	[1] PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
733	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬	D00182 💬	Norethisterone	[4] 13, 46, 49, 299 💬
734	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬	D00953 💬	Norethisterone	[4] 13, 46, 49, 299 💬
735	Progesterone-mediated oocyte maturation 💬	[1] PGR 💬	D05209 💬	Norgestimate	[1] 299 💬
736	Prolactin signaling pathway 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
737	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
738	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
739	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
740	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
741	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
742	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
743	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
744	Prolactin signaling pathway 💬	[2] ESR1, ESR2 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
745	Prolactin signaling pathway 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
746	Prostate cancer 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
747	Prostate cancer 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
748	Prostate cancer 💬	[1] IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
749	Protein digestion and absorption 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
750	Protein digestion and absorption 💬	[1] DPP4 💬	D08996 💬	Saxagliptin	[1] 299 💬
751	Protein digestion and absorption 💬	[1] DPP4 💬	D08516 💬	Sitagliptin	[4] 6 , 75, 233, 299 💬
752	Proteoglycans in cancer 💬	[1] ESR1 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
753	Proteoglycans in cancer 💬	[1] ESR1 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
754	Proteoglycans in cancer 💬	[1] ESR1 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
755	Proteoglycans in cancer 💬	[1] ESR1 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
756	Proteoglycans in cancer 💬	[1] ESR1 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
757	Proteoglycans in cancer 💬	[1] ESR1 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
758	Proteoglycans in cancer 💬	[1] ESR1 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
759	Proteoglycans in cancer 💬	[1] ESR1 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
760	Proteoglycans in cancer 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
761	Proteoglycans in cancer 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
762	Proteoglycans in cancer 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
763	Proximal tubule bicarbonate reclamation 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
764	Purine metabolism 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
765	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
766	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
767	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
768	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
769	Purine metabolism 💬	[16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
770	Purine metabolism 💬	[4] PDE4A, PDE4B, PDE4C, PDE4D 💬	D05744 💬	Roflumilast	[2] 84, 299 💬
771	Purine metabolism 💬	[1] PDE5A 💬	D02229 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
772	Purine metabolism 💬	[1] PDE5A 💬	D08514 💬	Sildenafil	[17] 6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
773	Purine metabolism 💬	[1] PDE5A 💬	D02731 💬	Vardenafil	[3] 13, 86, 299 💬
774	Purine metabolism 💬	[1] PDE5A 💬	D03260 💬	Vardenafil	[3] 13, 86, 299 💬
775	Purine metabolism 💬	[1] PDE5A 💬	D08668 💬	Vardenafil	[3] 13, 86, 299 💬
776	Rap1 signaling pathway 💬	[1] ADORA2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
777	Rap1 signaling pathway 💬	[1] ADORA2B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
778	Rap1 signaling pathway 💬	[1] ADORA2B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
779	Rap1 signaling pathway 💬	[1] ADORA2B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
780	Rap1 signaling pathway 💬	[1] ADORA2B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
781	Rap1 signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
782	Rap1 signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
783	Rap1 signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
784	Rap1 signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
785	Ras signaling pathway 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
786	Ras signaling pathway 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
787	Ras signaling pathway 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
788	Ras signaling pathway 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
789	Regulation of actin cytoskeleton 💬	[2] CHRM2, CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
790	Regulation of actin cytoskeleton 💬	[2] CHRM2, CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
791	Regulation of actin cytoskeleton 💬	[2] CHRM2, CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
792	Regulation of actin cytoskeleton 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
793	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
794	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
795	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
796	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
797	Regulation of lipolysis in adipocytes 💬	[2] ADORA1, PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
798	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
799	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
800	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
801	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
802	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
803	Regulation of lipolysis in adipocytes 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
804	Regulation of lipolysis in adipocytes 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
805	Regulation of lipolysis in adipocytes 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
806	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
807	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
808	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
809	Regulation of lipolysis in adipocytes 💬	[2] PTGS1, PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
810	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
811	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
812	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬	D02017 💬	Theophylline	[2] 236, 299 💬
813	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
814	Renin secretion 💬	[6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
815	Renin secretion 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
816	Renin secretion 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
817	Renin secretion 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
818	Renin secretion 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
819	Renin secretion 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
820	Renin secretion 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
821	Renin secretion 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
822	Renin secretion 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
823	Renin secretion 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
824	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
825	Renin secretion 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
826	Renin-angiotensin system 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
827	Renin-angiotensin system 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
828	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
829	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
830	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
831	Retrograde endocannabinoid signaling 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
832	Rheumatoid arthritis 💬	[1] TNFSF11 💬	D03684 💬	Denosumab	[7] 46, 50, 93, 95, 96, 274, 299 💬
833	Salivary secretion 💬	[1] ADRB2 💬	D01373 💬	Formoterol	[3] 85, 228, 299 💬
834	Salivary secretion 💬	[1] ADRB2 💬	D05277 💬	Formoterol	[3] 85, 228, 299 💬
835	Salivary secretion 💬	[1] ADRB2 💬	D07990 💬	Formoterol	[3] 85, 228, 299 💬
836	Salivary secretion 💬	[1] ADRB2 💬	D02147 💬	Salbutamol	[14] 3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
837	Salivary secretion 💬	[1] ADRB2 💬	D00687 💬	Salmeterol	[1] 299 💬
838	Salivary secretion 💬	[1] ADRB2 💬	D05792 💬	Salmeterol	[1] 299 💬
839	Salivary secretion 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
840	Salivary secretion 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
841	Salivary secretion 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
842	Salivary secretion 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
843	Salivary secretion 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
844	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
845	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
846	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
847	Serotonergic synapse 💬	[2] PTGS1, PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
848	Serotonergic synapse 💬	[1] SLC6A4 💬	D00809 💬	Amitriptyline	[4] 78, 97, 226, 299 💬
849	Serotonergic synapse 💬	[1] SLC6A4 💬	D07448 💬	Amitriptyline	[4] 78, 97, 226, 299 💬
850	Shigellosis 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
851	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
852	Signaling pathways regulating pluripotency of stem cells 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
853	Small cell lung cancer 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
854	Small cell lung cancer 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
855	Small cell lung cancer 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
856	Small cell lung cancer 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
857	Small cell lung cancer 💬	[1] RARB 💬	D04162 💬	Fenretinide	[1] 299 💬
858	Sphingolipid metabolism 💬	[1] UGCG 💬	D05032 💬	Miglustat	[3] 19, 256, 299 💬
859	Sphingolipid signaling pathway 💬	[1] ADORA1 💬	D00371 💬	Theophylline	[2] 236, 299 💬
860	Sphingolipid signaling pathway 💬	[1] ADORA1 💬	D01712 💬	Theophylline	[2] 236, 299 💬
861	Sphingolipid signaling pathway 💬	[1] ADORA1 💬	D02017 💬	Theophylline	[2] 236, 299 💬
862	Sphingolipid signaling pathway 💬	[1] ADORA1 💬	D06103 💬	Theophylline	[2] 236, 299 💬
863	Sphingolipid signaling pathway 💬	[1] ADORA1 💬	D06104 💬	Theophylline	[2] 236, 299 💬
864	Sphingolipid signaling pathway 💬	[1] FCER1A 💬	D05251 💬	Omalizumab	[7] 46, 53, 65, 98, 162, 226, 299 💬
865	Synaptic vesicle cycle 💬	[2] SLC6A2, SLC6A4 💬	D00809 💬	Amitriptyline	[4] 78, 97, 226, 299 💬
866	Synaptic vesicle cycle 💬	[2] SLC6A2, SLC6A4 💬	D07448 💬	Amitriptyline	[4] 78, 97, 226, 299 💬
867	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
868	T cell receptor signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
869	Taste transduction 💬	[1] CHRM3 💬	D00525 💬	Pilocarpine	[3] 6 , 53, 299 💬
870	Taste transduction 💬	[1] CHRM3 💬	D02200 💬	Pilocarpine	[3] 6 , 53, 299 💬
871	Taste transduction 💬	[1] CHRM3 💬	D05478 💬	Pilocarpine	[3] 6 , 53, 299 💬
872	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬	D00371 💬	Theophylline	[2] 236, 299 💬
873	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬	D01712 💬	Theophylline	[2] 236, 299 💬
874	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬	D02017 💬	Theophylline	[2] 236, 299 💬
875	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬	D06103 💬	Theophylline	[2] 236, 299 💬
876	Taste transduction 💬	[3] PDE1A, PDE1B, PDE1C 💬	D06104 💬	Theophylline	[2] 236, 299 💬
877	Taste transduction 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D00649 💬	Amiloride	[3] 13, 225, 299 💬
878	Taste transduction 💬	[3] SCNN1A, SCNN1B, SCNN1G 💬	D07447 💬	Amiloride	[3] 13, 225, 299 💬
879	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D00939 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
880	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D07119 💬	Alendronic acid	[7] 19, 41, 46, 50, 271, 274, 299 💬
881	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D01968 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
882	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D06378 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
883	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D06379 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
884	Terpenoid backbone biosynthesis 💬	[1] FDPS 💬	D08689 💬	Zoledronic acid	[10] 6 , 13, 46, 65, 93, 95, 96, 274, 299, 333 💬
885	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
886	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
887	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
888	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11] 6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
889	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21] 6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
890	Th1 and Th2 cell differentiation 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
891	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
892	Th1 and Th2 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
893	Th17 cell differentiation 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
894	Th17 cell differentiation 💬	[1] IL1R1 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
895	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
896	Th17 cell differentiation 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
897	Th17 cell differentiation 💬	[1] RARA 💬	D04162 💬	Fenretinide	[1] 299 💬
898	Thermogenesis 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
899	Thermogenesis 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
900	Thermogenesis 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
901	Thermogenesis 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
902	Thyroid cancer 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
903	Thyroid cancer 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
904	Thyroid hormone signaling pathway 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
905	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D00105 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
906	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D01413 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
907	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D01617 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
908	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D01953 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
909	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D04061 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
910	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D04063 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
911	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D04064 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
912	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D04065 💬	Estradiol	[5] 13, 46, 49, 226, 299 💬
913	Thyroid hormone signaling pathway 💬	[1] ESR1 💬	D00554 💬	Ethinylestradiol	[4] 13, 46, 49, 299 💬
914	Thyroid hormone synthesis 💬	[4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬	D00297 💬	Digitoxin	[1] 299 💬
915	Tight junction 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
916	Tight junction 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
917	Tight junction 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
918	Tight junction 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
919	Tight junction 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
920	Tight junction 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
921	Tight junction 💬	[2] PRKAA1, PRKAA2 💬	D00944 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
922	Tight junction 💬	[2] PRKAA1, PRKAA2 💬	D04966 💬	Metformin	[21] 2 , 6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
923	TNF signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
924	TNF signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
925	TNF signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
926	TNF signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
927	Toxoplasmosis 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
928	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬	D03297 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
929	Transcriptional misregulation in cancer 💬	[1] IGF1R 💬	D04870 💬	Mecasermin	[6] 65, 78, 96, 168, 265, 299 💬
930	Transcriptional misregulation in cancer 💬	[1] IL1R2 💬	D02934 💬	Anakinra	[19] 2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
931	Transcriptional misregulation in cancer 💬	[1] PPARG 💬	D00945 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
932	Transcriptional misregulation in cancer 💬	[1] PPARG 💬	D08378 💬	Pioglitazone	[17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
933	Transcriptional misregulation in cancer 💬	[1] RARA 💬	D04162 💬	Fenretinide	[1] 299 💬
934	Tuberculosis 💬	[2] IFNGR1, IFNGR2 💬	D00747 💬	Interferon gamma-1b	[7] 18, 65, 85, 228, 299, 301, 326 💬
935	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
936	Tuberculosis 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
937	Tuberculosis 💬	[1] VDR 💬	D00122 💬	Calcifediol	[2] 113, 299 💬
938	Tuberculosis 💬	[1] VDR 💬	D00188 💬	Cholecalciferol	[23] 6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 84, 85, 96, 97, 162, 202, 228, 271, 298, 299 💬
939	Tuberculosis 💬	[1] VDR 💬	D00187 💬	Ergocalciferol	[5] 46, 84, 96, 97, 299 💬
940	Type II diabetes mellitus 💬	[2] ABCC8, KCNJ11 💬	D00594 💬	Repaglinide	[3] 6 , 21, 299 💬
941	Type II diabetes mellitus 💬	[1] INSR 💬	D04539 💬	Insulin detemir	[1] 299 💬
942	Type II diabetes mellitus 💬	[1] INSR 💬	D03250 💬	Insulin glargine	[1] 299 💬
943	Vascular smooth muscle contraction 💬	[1] ADORA2A 💬	D02017 💬	Theophylline	[2] 236, 299 💬
944	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬	D00371 💬	Theophylline	[2] 236, 299 💬
945	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬	D01712 💬	Theophylline	[2] 236, 299 💬
946	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬	D06103 💬	Theophylline	[2] 236, 299 💬
947	Vascular smooth muscle contraction 💬	[1] ADORA2B 💬	D06104 💬	Theophylline	[2] 236, 299 💬
948	Vascular smooth muscle contraction 💬	[1] AGTR1 💬	D00357 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
949	Vascular smooth muscle contraction 💬	[1] AGTR1 💬	D08146 💬	Losartan	[18] 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
950	Vascular smooth muscle contraction 💬	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	D09572 💬	Riociguat	[6] 51, 84, 86, 88, 225, 299 💬
951	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
952	VEGF signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
953	VEGF signaling pathway 💬	[1] PTGS2 💬	D00126 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
954	VEGF signaling pathway 💬	[1] PTGS2 💬	D01122 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
955	VEGF signaling pathway 💬	[1] PTGS2 💬	D04490 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
956	VEGF signaling pathway 💬	[1] PTGS2 💬	D06606 💬	Ibuprofen	[6] 13, 46, 65, 113, 271, 299 💬
957	Vibrio cholerae infection 💬	[1] CFTR 💬	D11423 💬	Deutivacaftor	[1] 299 💬
958	Vibrio cholerae infection 💬	[1] CFTR 💬	D11507 💬	Elexacaftor	[1] 299 💬
959	Vibrio cholerae infection 💬	[1] CFTR 💬	D11724 💬	Galicaftor	[1] 299 💬
960	Vibrio cholerae infection 💬	[1] CFTR 💬	D09916 💬	Ivacaftor	[1] 299 💬
961	Vibrio cholerae infection 💬	[1] CFTR 💬	D10134 💬	Lumacaftor	[1] 299 💬
962	Vibrio cholerae infection 💬	[1] CFTR 💬	D11041 💬	Tezacaftor	[1] 299 💬
963	Viral protein interaction with cytokine and cytokine receptor 💬	[2] CXCR1, CXCR2 💬	D08984 💬	Reparixin	[2] 298, 299 💬
964	Viral protein interaction with cytokine and cytokine receptor 💬	[1] CXCR4 💬	D08971 💬	Plerixafor	[6] 19, 20, 51, 65, 285, 299 💬
965	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D00107 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬
966	Wnt signaling pathway 💬	[5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬	D08556 💬	Tacrolimus	[32] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 299 💬