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Target Gene/Pathway💬 Info on mouse-over

e.g. Sirolimus, Adalimumab, MAP2K

ABCDEFGH I JKLMNOPQRSTUVWXYZother

121 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related		 KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adipocytokine signaling pathway 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
2 Adipocytokine signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
3 Adipocytokine signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
4 African trypanosomiasis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
5 African trypanosomiasis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
6 African trypanosomiasis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
7 African trypanosomiasis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
8 African trypanosomiasis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
9 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
11 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
12 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
13 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
14 Allograft rejection 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
15 Allograft rejection 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
16 Allograft rejection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
17 Allograft rejection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
18 Alzheimer disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
19 Alzheimer disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
20 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
21 Alzheimer disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
22 Alzheimer disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
23 Amoebiasis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
24 Amoebiasis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
25 Amoebiasis 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
26 Amoebiasis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
27 Amoebiasis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
28 Amoebiasis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
29 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
30 Amyotrophic lateral sclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
31 Amyotrophic lateral sclerosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
32 Amyotrophic lateral sclerosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
33 Antifolate resistance 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
34 Antifolate resistance 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
35 Antifolate resistance 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
36 Antifolate resistance 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
37 Antifolate resistance 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
38 Antifolate resistance 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
39 Antigen processing and presentation 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
40 Antigen processing and presentation 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
41 Apoptosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
42 Apoptosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
43 Asthma 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
44 Asthma 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
45 Autoimmune thyroid disease 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
46 Axon guidance 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
47 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
48 Biosynthesis of cofactors 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
49 Biosynthesis of cofactors 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
50 C-type lectin receptor signaling pathway 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
51 C-type lectin receptor signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
52 C-type lectin receptor signaling pathway 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
53 C-type lectin receptor signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
54 C-type lectin receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
55 C-type lectin receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
56 C-type lectin receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
57 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
58 Calcium signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
59 Calcium signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
60 cAMP signaling pathway 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
61 cAMP signaling pathway 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
62 Cell adhesion molecules 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
63 Cell adhesion molecules 💬
 [1] PDCD1 💬 D10316 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
64 Cellular senescence 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
65 Cellular senescence 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
66 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
67 cGMP-PKG signaling pathway 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
68 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D02095 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
69 cGMP-PKG signaling pathway 💬
 [1] OPRD1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
70 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
71 Chagas disease 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
72 Chagas disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
73 Chagas disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
74 Chagas disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
75 Chagas disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
76 Chemokine signaling pathway 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
77 Cholinergic synapse 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
78 Coronavirus disease - COVID-19 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
79 Coronavirus disease - COVID-19 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
80 Coronavirus disease - COVID-19 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
81 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
82 Coronavirus disease - COVID-19 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
83 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
84 Coronavirus disease - COVID-19 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
85 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
86 Coronavirus disease - COVID-19 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
87 Cytokine-cytokine receptor interaction 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
88 Cytokine-cytokine receptor interaction 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [33]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
89 Cytokine-cytokine receptor interaction 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
90 Cytokine-cytokine receptor interaction 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [7] 13, 37, 41, 46, 160, 269, 271 💬
91 Cytokine-cytokine receptor interaction 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
92 Cytokine-cytokine receptor interaction 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
93 Cytokine-cytokine receptor interaction 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
94 Cytokine-cytokine receptor interaction 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
95 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
96 Cytokine-cytokine receptor interaction 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
97 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
98 Cytokine-cytokine receptor interaction 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
99 Cytosolic DNA-sensing pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
100 Cytosolic DNA-sensing pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
101 Dilated cardiomyopathy 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
102 Dilated cardiomyopathy 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
103 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
104 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
105 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
106 EGFR tyrosine kinase inhibitor resistance 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
107 EGFR tyrosine kinase inhibitor resistance 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
108 EGFR tyrosine kinase inhibitor resistance 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
109 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] VDR 💬 D01518 💬 Alfacalcidol [6] 41, 46, 49, 50, 96, 235 💬
110 Epstein-Barr virus infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
111 Epstein-Barr virus infection 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
112 Epstein-Barr virus infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
113 Epstein-Barr virus infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
114 Epstein-Barr virus infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
115 Estrogen signaling pathway 💬
 [1] OPRM1 💬 D02095 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
116 Estrogen signaling pathway 💬
 [1] OPRM1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
117 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
118 Fc epsilon RI signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
119 Fluid shear stress and atherosclerosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
120 Fluid shear stress and atherosclerosis 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
121 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
122 Fluid shear stress and atherosclerosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
123 Folate biosynthesis 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
124 Folate biosynthesis 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
125 FoxO signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
126 Glucagon signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
127 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
128 Graft-versus-host disease 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
129 Graft-versus-host disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
130 Graft-versus-host disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
131 Graft-versus-host disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
132 Graft-versus-host disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
133 Growth hormone synthesis, secretion and action 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
134 Hematopoietic cell lineage 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
135 Hematopoietic cell lineage 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [33]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
136 Hematopoietic cell lineage 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
137 Hematopoietic cell lineage 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
138 Hematopoietic cell lineage 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
139 Hematopoietic cell lineage 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
140 Hematopoietic cell lineage 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
141 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [47] 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
142 Hematopoietic cell lineage 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
143 Hematopoietic cell lineage 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
144 Hepatitis B 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
145 Hepatitis B 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
146 Hepatitis B 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
147 Hepatitis B 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
148 Hepatitis B 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
149 Hepatitis C 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
150 Hepatitis C 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
151 Hepatitis C 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
152 Hepatitis C 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
153 Herpes simplex virus 1 infection 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
154 Herpes simplex virus 1 infection 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
155 Herpes simplex virus 1 infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
156 Herpes simplex virus 1 infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
157 Herpes simplex virus 1 infection 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
158 Herpes simplex virus 1 infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
159 Herpes simplex virus 1 infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
160 HIF-1 signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
161 HIF-1 signaling pathway 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
162 HIF-1 signaling pathway 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
163 Human cytomegalovirus infection 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
164 Human cytomegalovirus infection 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
165 Human cytomegalovirus infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
166 Human cytomegalovirus infection 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
167 Human cytomegalovirus infection 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
168 Human cytomegalovirus infection 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
169 Human cytomegalovirus infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
170 Human cytomegalovirus infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
171 Human cytomegalovirus infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
172 Human cytomegalovirus infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
173 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
174 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
175 Human immunodeficiency virus 1 infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
176 Human papillomavirus infection 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
177 Human papillomavirus infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
178 Human papillomavirus infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
179 Human papillomavirus infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
180 Human T-cell leukemia virus 1 infection 💬
 [1] FDPS 💬 D00939 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
181 Human T-cell leukemia virus 1 infection 💬
 [1] FDPS 💬 D07119 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
182 Human T-cell leukemia virus 1 infection 💬
 [2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
183 Human T-cell leukemia virus 1 infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
184 Human T-cell leukemia virus 1 infection 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
185 Human T-cell leukemia virus 1 infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
186 Human T-cell leukemia virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
187 Human T-cell leukemia virus 1 infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
188 Human T-cell leukemia virus 1 infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
189 Hypertrophic cardiomyopathy 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
190 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
191 Hypertrophic cardiomyopathy 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
192 IL-17 signaling pathway 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [7] 13, 37, 41, 46, 160, 269, 271 💬
193 IL-17 signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
194 IL-17 signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
195 IL-17 signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
196 IL-17 signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
197 Inflammatory bowel disease 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
198 Inflammatory bowel disease 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [7] 13, 37, 41, 46, 160, 269, 271 💬
199 Inflammatory bowel disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
200 Inflammatory bowel disease 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
201 Inflammatory bowel disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
202 Inflammatory bowel disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
203 Inflammatory bowel disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
204 Inflammatory mediator regulation of TRP channels 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
205 Inflammatory mediator regulation of TRP channels 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
206 Influenza A 💬
 [1] FDPS 💬 D00939 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
207 Influenza A 💬
 [1] FDPS 💬 D07119 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
208 Influenza A 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
209 Influenza A 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
210 Influenza A 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
211 Influenza A 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
212 Influenza A 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
213 Influenza A 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
214 Influenza A 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
215 Insulin resistance 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
216 Insulin resistance 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
217 Insulin resistance 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
218 Intestinal immune network for IgA production 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
219 Intestinal immune network for IgA production 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
220 JAK-STAT signaling pathway 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
221 JAK-STAT signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [33]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
222 JAK-STAT signaling pathway 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
223 JAK-STAT signaling pathway 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
224 JAK-STAT signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
225 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
226 JAK-STAT signaling pathway 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
227 JAK-STAT signaling pathway 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
228 JAK-STAT signaling pathway 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
229 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
230 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
231 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
232 Kaposi sarcoma-associated herpesvirus infection 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
233 Kaposi sarcoma-associated herpesvirus infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
234 Legionellosis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
235 Legionellosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
236 Legionellosis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
237 Legionellosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
238 Legionellosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
239 Leishmaniasis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
240 Leishmaniasis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
241 Leishmaniasis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
242 Leishmaniasis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
243 Leishmaniasis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
244 Leishmaniasis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
245 Long-term potentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
246 Malaria 💬
 [1] IL12A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
247 Malaria 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
248 Malaria 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
249 Malaria 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
250 Malaria 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
251 MAPK signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
252 MAPK signaling pathway 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
253 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
254 MAPK signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
255 MAPK signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
256 Measles 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
257 Measles 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
258 Measles 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
259 Measles 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
260 Measles 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
261 Melanogenesis 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
262 Melanogenesis 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
263 Metabolic pathways 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
264 Metabolic pathways 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
265 Metabolic pathways 💬
 [1] FDPS 💬 D00939 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
266 Metabolic pathways 💬
 [1] FDPS 💬 D07119 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
267 Mineral absorption 💬
 [1] VDR 💬 D01518 💬 Alfacalcidol [6] 41, 46, 49, 50, 96, 235 💬
268 Morphine addiction 💬
 [1] OPRM1 💬 D02095 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
269 Morphine addiction 💬
 [1] OPRM1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
270 mTOR signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
271 mTOR signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
272 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
273 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
274 Natural killer cell mediated cytotoxicity 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
275 Necroptosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
276 Necroptosis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
277 Necroptosis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
278 Necroptosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
279 Necroptosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
280 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
281 Neuroactive ligand-receptor interaction 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
282 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00407 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
283 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00751 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
284 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00979 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
285 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05000 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
286 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05001 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
287 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05002 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
288 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00472 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
289 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00980 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
290 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00981 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
291 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00982 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
292 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01239 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
293 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01998 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
294 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02156 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
295 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D03301 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
296 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [47]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
297 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D08416 💬 Prednisone acetate [6] 35, 40, 41, 49, 162, 224 💬
298 Neuroactive ligand-receptor interaction 💬
 [3] OPRD1, OPRK1, OPRM1 💬 D02095 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
299 Neuroactive ligand-receptor interaction 💬
 [3] OPRD1, OPRK1, OPRM1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
300 NF-kappa B signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
301 NF-kappa B signaling pathway 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
302 NF-kappa B signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
303 NF-kappa B signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
304 NOD-like receptor signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
305 NOD-like receptor signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
306 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
307 NOD-like receptor signaling pathway 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
308 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
309 NOD-like receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
310 Non-alcoholic fatty liver disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
311 Non-alcoholic fatty liver disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
312 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
313 Non-alcoholic fatty liver disease 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
314 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
315 Non-alcoholic fatty liver disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
316 One carbon pool by folate 💬
 [2] DHFR, DHFR2 💬 D00142 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
317 One carbon pool by folate 💬
 [2] DHFR, DHFR2 💬 D02115 💬 Methotrexate [35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
318 Oocyte meiosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
319 Osteoclast differentiation 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
320 Osteoclast differentiation 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
321 Osteoclast differentiation 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
322 Osteoclast differentiation 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
323 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
324 Osteoclast differentiation 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
325 Osteoclast differentiation 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
326 Oxytocin signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
327 Pancreatic cancer 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
328 Pancreatic cancer 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
329 Parathyroid hormone synthesis, secretion and action 💬
 [1] VDR 💬 D01518 💬 Alfacalcidol [6] 41, 46, 49, 50, 96, 235 💬
330 Pathogenic Escherichia coli infection 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
331 Pathogenic Escherichia coli infection 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
332 Pathogenic Escherichia coli infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
333 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
334 Pathogenic Escherichia coli infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
335 Pathways in cancer 💬
 [1] CSF2RA 💬 D09930 💬 Mavrilimumab [2] 41, 46 💬
336 Pathways in cancer 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [33]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
337 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
338 Pathways in cancer 💬
 [2] EDNRA, EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
339 Pathways in cancer 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
340 Pathways in cancer 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
341 Pathways in cancer 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
342 Pathways in cancer 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
343 Pathways in cancer 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
344 Pathways in cancer 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
345 Pathways in cancer 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
346 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
347 Pathways of neurodegeneration - multiple diseases 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
348 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
349 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
350 Pathways of neurodegeneration - multiple diseases 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
351 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
352 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
353 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] PDCD1 💬 D10316 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
354 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
355 Pertussis 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
356 Pertussis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
357 Pertussis 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
358 Pertussis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
359 Pertussis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
360 Pertussis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
361 PI3K-Akt signaling pathway 💬
 [1] CSF3R 💬 D03235 💬 Filgrastim [33]  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
362 PI3K-Akt signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
363 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
364 PI3K-Akt signaling pathway 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
365 PI3K-Akt signaling pathway 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
366 PI3K-Akt signaling pathway 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
367 Prion disease 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
368 Prion disease 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
369 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
370 Prion disease 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
371 Prion disease 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
372 Prolactin signaling pathway 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
373 Prostate cancer 💬
 [1] IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
374 Proteoglycans in cancer 💬
 [1] IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
375 Proteoglycans in cancer 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
376 Proteoglycans in cancer 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
377 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
378 Relaxin signaling pathway 💬
 [1] EDNRB 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
379 Renin secretion 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
380 Renin secretion 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
381 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
382 Rheumatoid arthritis 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
383 Rheumatoid arthritis 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [7] 13, 37, 41, 46, 160, 269, 271 💬
384 Rheumatoid arthritis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
385 Rheumatoid arthritis 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
386 Rheumatoid arthritis 💬
 [1] IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
387 Rheumatoid arthritis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
388 Rheumatoid arthritis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
389 Rheumatoid arthritis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
390 RIG-I-like receptor signaling pathway 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
391 RIG-I-like receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
392 RIG-I-like receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
393 Salmonella infection 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
394 Salmonella infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
395 Salmonella infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
396 Salmonella infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
397 Shigellosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
398 Shigellosis 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
399 Shigellosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
400 Shigellosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
401 Signaling pathways regulating pluripotency of stem cells 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
402 Signaling pathways regulating pluripotency of stem cells 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
403 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D02095 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
404 Sphingolipid signaling pathway 💬
 [1] OPRD1 💬 D05113 💬 Naltrexone [13]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
405 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
406 Sphingolipid signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
407 Systemic lupus erythematosus 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
408 Systemic lupus erythematosus 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
409 Systemic lupus erythematosus 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
410 T cell receptor signaling pathway 💬
 [1] PDCD1 💬 D10316 💬 Nivolumab [12] 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
411 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
412 T cell receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
413 T cell receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
414 Terpenoid backbone biosynthesis 💬
 [1] FDPS 💬 D00939 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
415 Terpenoid backbone biosynthesis 💬
 [1] FDPS 💬 D07119 💬 Alendronic acid [7] 19, 41, 46, 50, 271, 274, 299 💬
416 TGF-beta signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
417 TGF-beta signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
418 Th1 and Th2 cell differentiation 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
419 Th1 and Th2 cell differentiation 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
420 Th1 and Th2 cell differentiation 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
421 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
422 Th17 cell differentiation 💬
 [1] IL17A 💬 D09967 💬 Secukinumab [7] 13, 37, 41, 46, 160, 269, 271 💬
423 Th17 cell differentiation 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
424 Th17 cell differentiation 💬
 [1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
425 Th17 cell differentiation 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
426 Th17 cell differentiation 💬
 [1] IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
427 Th17 cell differentiation 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
428 Th17 cell differentiation 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
429 Th17 cell differentiation 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
430 Th17 cell differentiation 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
431 Th17 cell differentiation 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
432 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
433 TNF signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
434 TNF signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
435 TNF signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
436 TNF signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
437 Toll-like receptor signaling pathway 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
438 Toll-like receptor signaling pathway 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
439 Toll-like receptor signaling pathway 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
440 Toll-like receptor signaling pathway 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
441 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
442 Toll-like receptor signaling pathway 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
443 Toxoplasmosis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
444 Toxoplasmosis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
445 Toxoplasmosis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
446 Toxoplasmosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
447 Toxoplasmosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
448 Transcriptional misregulation in cancer 💬
 [1] CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
449 Transcriptional misregulation in cancer 💬
 [1] IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
450 Transcriptional misregulation in cancer 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
451 Tuberculosis 💬
 [3] IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
452 Tuberculosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
453 Tuberculosis 💬
 [1] IL23A 💬 D10438 💬 Guselkumab [4] 37, 41, 96, 97 💬
454 Tuberculosis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
455 Tuberculosis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
456 Tuberculosis 💬
 [2] JAK1, JAK2 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
457 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
458 Tuberculosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
459 Tuberculosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
460 Tuberculosis 💬
 [1] VDR 💬 D01518 💬 Alfacalcidol [6] 41, 46, 49, 50, 96, 235 💬
461 Type I diabetes mellitus 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
462 Type I diabetes mellitus 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬
463 Type I diabetes mellitus 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
464 Type I diabetes mellitus 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
465 Type I diabetes mellitus 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
466 Type II diabetes mellitus 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
467 Type II diabetes mellitus 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
468 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D01227 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
469 Vascular smooth muscle contraction 💬
 [1] EDNRA 💬 D07538 💬 Bosentan [11] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
470 VEGF signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
471 Viral carcinogenesis 💬
 [1] JAK1 💬 D10308 💬 Baricitinib [9] 41, 46, 49, 50, 93, 107, 265, 268, 325 💬
472 Viral carcinogenesis 💬
 [1] JAK1 💬 D10994 💬 Upadacitinib [7] 40, 41, 46, 49, 96, 97, 271 💬
473 Viral myocarditis 💬
 [2] CD80, CD86 💬 D03203 💬 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
474 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
475 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6R 💬 D10161 💬 Sarilumab [5] 41, 46, 84, 107, 271 💬
476 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] IL6R 💬 D02596 💬 Tocilizumab [18]  2 , 13, 40, 41, 42, 43, 46, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
477 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
478 Viral protein interaction with cytokine and cytokine receptor 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬
479 Wnt signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
480 Yersinia infection 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
481 Yersinia infection 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
482 Yersinia infection 💬
 [1] TNF 💬 D02597 💬 Adalimumab [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬
483 Yersinia infection 💬
 [1] TNF 💬 D02598 💬 Infliximab [25] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 162, 164, 269, 271 💬

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