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Target Gene/Pathway💬 Info on mouse-over

e.g. Sirolimus, Adalimumab, MAP2K

ABCDEFGH I JKLMNOPQRSTUVWXYZother

132 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related		 KEGG GENES KEGG DRUG DrugBank Disease ID
1 Acute myeloid leukemia 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
2 Acute myeloid leukemia 💬
 [2] PML, RARA 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
3 Adipocytokine signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
4 Alcoholism 💬
 [1] ADORA2B 💬 D00227 💬 Aminophylline [1] 63 💬
5 Alcoholism 💬
 [1] ADORA2B 💬 D05429 💬 Aminophylline [1] 63 💬
6 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00227 💬 Aminophylline [1] 63 💬
7 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D05429 💬 Aminophylline [1] 63 💬
8 Allograft rejection 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
9 Alzheimer disease 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
10 Alzheimer disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
11 Alzheimer disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
12 Amphetamine addiction 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
13 AMPK signaling pathway 💬
 [1] HMGCR 💬 D00887 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
14 AMPK signaling pathway 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
15 AMPK signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
16 Amyotrophic lateral sclerosis 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
17 Amyotrophic lateral sclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
18 Amyotrophic lateral sclerosis 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
19 Apelin signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
20 Apelin signaling pathway 💬
 [1] PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
21 Apelin signaling pathway 💬
 [1] PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
22 Arrhythmogenic right ventricular cardiomyopathy 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
23 Asthma 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
24 Autoimmune thyroid disease 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
25 Autophagy - animal 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
26 Autophagy - other 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
27 Axon guidance 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
28 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
29 Bile secretion 💬
 [1] HMGCR 💬 D00887 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
30 Bile secretion 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
31 Breast cancer 💬
 [2] ESR1, PGR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
32 Breast cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
33 C-type lectin receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
34 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D00227 💬 Aminophylline [1] 63 💬
35 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D05429 💬 Aminophylline [1] 63 💬
36 Calcium signaling pathway 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
37 Calcium signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
38 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D00227 💬 Aminophylline [1] 63 💬
39 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D05429 💬 Aminophylline [1] 63 💬
40 Cell adhesion molecules 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
41 Cell adhesion molecules 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
42 Cellular senescence 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
43 Cellular senescence 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
44 Central carbon metabolism in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
45 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
46 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
47 cGMP-PKG signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
48 Choline metabolism in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
49 Collecting duct acid secretion 💬
 [2] ATP4A, ATP4B 💬 D00355 💬 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299 💬
50 Collecting duct acid secretion 💬
 [2] ATP4A, ATP4B 💬 D11784 💬 Vonoprazan [2] 63, 98 💬
51 Colorectal cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
52 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D00227 💬 Aminophylline [1] 63 💬
53 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D05429 💬 Aminophylline [1] 63 💬
54 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D00227 💬 Aminophylline [1] 63 💬
55 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D05429 💬 Aminophylline [1] 63 💬
56 Cysteine and methionine metabolism 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
57 Cytokine-cytokine receptor interaction 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
58 Cytokine-cytokine receptor interaction 💬
 [1] MPL 💬 D08990 💬 Romiplostim [4] 60, 63, 64, 65 💬
59 Diabetic cardiomyopathy 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
60 Dilated cardiomyopathy 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
61 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
62 ECM-receptor interaction 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
63 EGFR tyrosine kinase inhibitor resistance 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
64 Endocrine and other factor-regulated calcium reabsorption 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
65 Endocrine resistance 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
66 Endocrine resistance 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
67 Endocytosis 💬
 [1] PML 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
68 ErbB signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
69 Estrogen signaling pathway 💬
 [2] ESR1, PGR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
70 Estrogen signaling pathway 💬
 [1] RARA 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
71 Focal adhesion 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
72 Gastric acid secretion 💬
 [2] ATP4A, ATP4B 💬 D00355 💬 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299 💬
73 Gastric acid secretion 💬
 [2] ATP4A, ATP4B 💬 D11784 💬 Vonoprazan [2] 63, 98 💬
74 Gastric cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
75 Gastric cancer 💬
 [1] RARB 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
76 Glioma 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
77 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
78 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
79 Glucagon signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
80 Glutamatergic synapse 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
81 Growth hormone synthesis, secretion and action 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
82 Hematopoietic cell lineage 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
83 Hematopoietic cell lineage 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
84 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [47] 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
85 Hepatocellular carcinoma 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
86 Herpes simplex virus 1 infection 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
87 Herpes simplex virus 1 infection 💬
 [1] PML 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
88 HIF-1 signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
89 Human cytomegalovirus infection 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
90 Human cytomegalovirus infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
91 Human immunodeficiency virus 1 infection 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
92 Human immunodeficiency virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
93 Human papillomavirus infection 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
94 Human papillomavirus infection 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
95 Human T-cell leukemia virus 1 infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
96 Huntington disease 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
97 Huntington disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
98 Hypertrophic cardiomyopathy 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
99 Influenza A 💬
 [1] PML 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
100 Insulin resistance 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
101 Insulin signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
102 Insulin signaling pathway 💬
 [1] PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
103 Insulin signaling pathway 💬
 [1] PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
104 Intestinal immune network for IgA production 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
105 Intestinal immune network for IgA production 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
106 JAK-STAT signaling pathway 💬
 [1] MPL 💬 D08990 💬 Romiplostim [4] 60, 63, 64, 65 💬
107 JAK-STAT signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
108 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
109 Kaposi sarcoma-associated herpesvirus infection 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
110 Leishmaniasis 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
111 Leukocyte transendothelial migration 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
112 Long-term potentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
113 Longevity regulating pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
114 Longevity regulating pathway - multiple species 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
115 Malaria 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
116 MAPK signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
117 Metabolic pathways 💬
 [2] ATP4A, ATP4B 💬 D00355 💬 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299 💬
118 Metabolic pathways 💬
 [2] ATP4A, ATP4B 💬 D11784 💬 Vonoprazan [2] 63, 98 💬
119 Metabolic pathways 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
120 Metabolic pathways 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
121 Metabolic pathways 💬
 [1] HMGCR 💬 D00887 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
122 Metabolic pathways 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
123 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00227 💬 Aminophylline [1] 63 💬
124 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D05429 💬 Aminophylline [1] 63 💬
125 MicroRNAs in cancer 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
126 MicroRNAs in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
127 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00227 💬 Aminophylline [1] 63 💬
128 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D05429 💬 Aminophylline [1] 63 💬
129 mTOR signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
130 Natural killer cell mediated cytotoxicity 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
131 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D00227 💬 Aminophylline [1] 63 💬
132 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D05429 💬 Aminophylline [1] 63 💬
133 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00292 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
134 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00975 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
135 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01510 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
136 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01615 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
137 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01632 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
138 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01948 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
139 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02174 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
140 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02591 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
141 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02592 💬 Dexamethasone [25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 162, 222, 235, 283, 296, 299 💬
142 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00407 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
143 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00751 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
144 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00979 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
145 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05000 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
146 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05001 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
147 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D05002 💬 Methylprednisolone [44]  2 ,  6 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
148 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00472 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
149 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00980 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
150 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00981 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
151 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00982 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
152 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01239 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
153 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D01998 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
154 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D02156 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
155 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D03301 💬 Prednisolone [40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
156 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [47]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
157 Neutrophil extracellular trap formation 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
158 NF-kappa B signaling pathway 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
159 Nicotinate and nicotinamide metabolism 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
160 Non-small cell lung cancer 💬
 [1] RARB 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
161 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D00227 💬 Aminophylline [1] 63 💬
162 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D05429 💬 Aminophylline [1] 63 💬
163 Oocyte meiosis 💬
 [2] AR, PGR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
164 Oocyte meiosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
165 Osteoclast differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
166 Oxidative phosphorylation 💬
 [2] ATP4A, ATP4B 💬 D00355 💬 Lansoprazole [7] 63, 71, 85, 98, 166, 222, 299 💬
167 Oxidative phosphorylation 💬
 [2] ATP4A, ATP4B 💬 D11784 💬 Vonoprazan [2] 63, 98 💬
168 Oxytocin signaling pathway 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
169 Oxytocin signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
170 Pancreatic cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
171 Pancreatic secretion 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
172 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D00227 💬 Aminophylline [1] 63 💬
173 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D05429 💬 Aminophylline [1] 63 💬
174 Parkinson disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
175 Pathways in cancer 💬
 [2] AR, ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
176 Pathways in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
177 Pathways in cancer 💬
 [3] PML, RARA, RARB 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
178 Pathways of neurodegeneration - multiple diseases 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
179 Pathways of neurodegeneration - multiple diseases 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
180 Pathways of neurodegeneration - multiple diseases 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
181 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
182 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
183 Phospholipase D signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
184 PI3K-Akt signaling pathway 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
185 PI3K-Akt signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
186 Primary immunodeficiency 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
187 Prion disease 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
188 Prion disease 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
189 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
190 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
191 Progesterone-mediated oocyte maturation 💬
 [1] PGR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
192 Prolactin signaling pathway 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
193 Prostate cancer 💬
 [1] AR 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
194 Prostate cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
195 Proteasome 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
196 Proteoglycans in cancer 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
197 Proteoglycans in cancer 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
198 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00227 💬 Aminophylline [1] 63 💬
199 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D05429 💬 Aminophylline [1] 63 💬
200 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D00227 💬 Aminophylline [1] 63 💬
201 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D05429 💬 Aminophylline [1] 63 💬
202 Regulation of actin cytoskeleton 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬
203 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
204 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
205 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D00227 💬 Aminophylline [1] 63 💬
206 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D05429 💬 Aminophylline [1] 63 💬
207 Renin secretion 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
208 Salivary secretion 💬
 [1] CD38 💬 D10777 💬 Daratumumab [4] 16, 28, 63, 222 💬
209 Shigellosis 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
210 Small cell lung cancer 💬
 [1] RARB 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
211 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D00227 💬 Aminophylline [1] 63 💬
212 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D05429 💬 Aminophylline [1] 63 💬
213 Spinocerebellar ataxia 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
214 Spinocerebellar ataxia 💬
 [1] PSMB5 💬 D03150 💬 Bortezomib [15] 11, 13, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 283, 288, 331 💬
215 Systemic lupus erythematosus 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
216 T cell receptor signaling pathway 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
217 T cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
218 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D00227 💬 Aminophylline [1] 63 💬
219 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D05429 💬 Aminophylline [1] 63 💬
220 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D00887 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
221 Terpenoid backbone biosynthesis 💬
 [1] HMGCR 💬 D07474 💬 Atorvastatin [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
222 Th1 and Th2 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
223 Th17 cell differentiation 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
224 Th17 cell differentiation 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
225 Th17 cell differentiation 💬
 [1] RARA 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
226 Thermogenesis 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
227 Thyroid hormone signaling pathway 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
228 Thyroid hormone signaling pathway 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
229 Toxoplasmosis 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
230 Transcriptional misregulation in cancer 💬
 [2] PML, RARA 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
231 Tuberculosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
232 Type II diabetes mellitus 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
233 Ubiquitin mediated proteolysis 💬
 [1] PML 💬 D00094 💬 Tretinoin [5]  2 , 63, 75, 94, 231 💬
234 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D00227 💬 Aminophylline [1] 63 💬
235 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D05429 💬 Aminophylline [1] 63 💬
236 VEGF signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
237 Viral myocarditis 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
238 Wnt signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [43] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
239 Yersinia infection 💬
 [1] ITGA4 💬 D06886 💬 Natalizumab [6] 13, 15, 25, 46, 63, 96 💬

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