Target Gene/Pathway💬 Info on mouse-over

No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Adipocytokine signaling pathway 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
2	AMPK signaling pathway 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
3	AMPK signaling pathway 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
4	AMPK signaling pathway 💬	[1] HMGCR 💬	D00892 💬	Fluvastatin	[3] 79, 218, 222 💬
5	AMPK signaling pathway 💬	[1] HMGCR 💬	D07983 💬	Fluvastatin	[3] 79, 218, 222 💬
6	AMPK signaling pathway 💬	[1] HMGCR 💬	D00359 💬	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
7	AMPK signaling pathway 💬	[1] HMGCR 💬	D00893 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
8	AMPK signaling pathway 💬	[1] HMGCR 💬	D08410 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
9	AMPK signaling pathway 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
10	AMPK signaling pathway 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
11	AMPK signaling pathway 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
12	Bile secretion 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
13	Bile secretion 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
14	Bile secretion 💬	[1] HMGCR 💬	D00892 💬	Fluvastatin	[3] 79, 218, 222 💬
15	Bile secretion 💬	[1] HMGCR 💬	D07983 💬	Fluvastatin	[3] 79, 218, 222 💬
16	Bile secretion 💬	[1] HMGCR 💬	D00359 💬	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
17	Bile secretion 💬	[1] HMGCR 💬	D00893 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
18	Bile secretion 💬	[1] HMGCR 💬	D08410 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
19	Bile secretion 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
20	Bile secretion 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
21	Bile secretion 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
22	cAMP signaling pathway 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
23	Cholesterol metabolism 💬	[1] ANGPTL3 💬	D11753 💬	Evinacumab	[1] 79 💬
24	Cholesterol metabolism 💬	[1] CETP 💬	D08855 💬	Anacetrapib	[1] 79 💬
25	Cholesterol metabolism 💬	[1] PCSK9 💬	D10335 💬	Alirocumab	[1] 79 💬
26	Cholesterol metabolism 💬	[1] PCSK9 💬	D10557 💬	Evolocumab	[2] 79, 222 💬
27	Cholesterol metabolism 💬	[1] PCSK9 💬	D11931 💬	Inclisiran	[1] 79 💬
28	Complement and coagulation cascades 💬	[1] SERPINC1 💬	D07510 💬	Heparin	[11] 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 💬
29	Diabetic cardiomyopathy 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
30	Fat digestion and absorption 💬	[1] MTTP 💬	D09637 💬	Lomitapide	[1] 79 💬
31	Fat digestion and absorption 💬	[1] NPC1L1 💬	D01966 💬	Ezetimibe	[4] 49, 79, 93, 260 💬
32	Glucagon signaling pathway 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
33	Hepatitis C 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
34	Insulin resistance 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
35	Metabolic pathways 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
36	Metabolic pathways 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
37	Metabolic pathways 💬	[1] HMGCR 💬	D00892 💬	Fluvastatin	[3] 79, 218, 222 💬
38	Metabolic pathways 💬	[1] HMGCR 💬	D07983 💬	Fluvastatin	[3] 79, 218, 222 💬
39	Metabolic pathways 💬	[1] HMGCR 💬	D00359 💬	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
40	Metabolic pathways 💬	[1] HMGCR 💬	D00893 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
41	Metabolic pathways 💬	[1] HMGCR 💬	D08410 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
42	Metabolic pathways 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
43	Metabolic pathways 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
44	Metabolic pathways 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
45	Non-alcoholic fatty liver disease 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
46	PPAR signaling pathway 💬	[1] PPARA 💬	D00565 💬	Fenofibrate	[5]  8 , 79, 93, 94, 265 💬
47	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00887 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
48	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D07474 💬	Atorvastatin	[17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 💬
49	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00892 💬	Fluvastatin	[3] 79, 218, 222 💬
50	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D07983 💬	Fluvastatin	[3] 79, 218, 222 💬
51	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00359 💬	Lovastatin	[11]  6 , 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
52	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00893 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
53	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D08410 💬	Pravastatin	[9] 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
54	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D01915 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
55	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D08492 💬	Rosuvastatin	[11]  6 , 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
56	Terpenoid backbone biosynthesis 💬	[1] HMGCR 💬	D00434 💬	Simvastatin	[21]  6 , 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬

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