DDrare: Database of Drug Development for Rare Diseases

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No.	KEGG PATHWAY On map, Yellow: Drug target, Red: All disease-related	KEGG GENES	KEGG DRUG	DrugBank	Disease ID
1	Acute myeloid leukemia 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
2	Acute myeloid leukemia 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
3	Adipocytokine signaling pathway 💬	[1] MTOR 💬	D00753 💬	Sirolimus	[40] 2 , 6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
4	Adipocytokine signaling pathway 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
5	African trypanosomiasis 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
6	AGE-RAGE signaling pathway in diabetic complications 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
7	AGE-RAGE signaling pathway in diabetic complications 💬	[1] VEGFA 💬	D06409 💬	Bevacizumab	[9] 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
8	Alcoholism 💬	[1] MAP2K1 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬
9	Allograft rejection 💬	[1] TNF 💬	D00754 💬	Thalidomide	[20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
10	Alzheimer disease 💬	[2] MAP2K1, MAP2K2 💬	D10175 💬	Trametinib	[4] 2 , 34, 279, 280 💬

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