Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 💬 2件: Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
2 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
3 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
4 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
5 ADORA2A 💬 7件: Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Parkinson disease, Alcoholism Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
6 ADRA2A 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Dexmedetomidine 💬 Dexmedetomidine 14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
7 ADRA2B 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Dexmedetomidine 💬 Dexmedetomidine 14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
8 ADRA2C 💬 2件: cGMP-PKG signaling pathway, Neuroactive ligand-receptor interaction Dexmedetomidine 💬 Dexmedetomidine 14件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
9 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Cariprazine 💬 Cariprazine 1件: 21 💬
10 GABRA1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
11 GABRA1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
12 GABRA2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
13 GABRA2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
14 GABRA3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
15 GABRA3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
16 GABRA4 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
17 GABRA4 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
18 GABRA5 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
19 GABRA5 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
20 GABRA6 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
21 GABRA6 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Taste transduction, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
22 GABRB1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
23 GABRB1 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
24 GABRB2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
25 GABRB2 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
26 GABRB3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
27 GABRB3 💬 6件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, Serotonergic synapse, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
28 GABRD 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
29 GABRD 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
30 GABRE 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
31 GABRE 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
32 GABRG1 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
33 GABRG1 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
34 GABRG2 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
35 GABRG2 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
36 GABRG3 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
37 GABRG3 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
38 GABRP 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
39 GABRP 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
40 GRIN1 💬 18件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
41 GRIN2A 💬 19件: Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
42 GRIN2B 💬 19件: Ras signaling pathway, Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism, Systemic lupus erythematosus Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
43 GRIN2C 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
44 GRIN2D 💬 15件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Circadian entrainment, Long-term potentiation, Glutamatergic synapse, Alzheimer disease, Amyotrophic lateral sclerosis, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Nicotine addiction, Alcoholism Dextromethorphan 💬 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
45 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Cariprazine 💬 Cariprazine 1件: 21 💬
46 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Cariprazine 💬 Cariprazine 1件: 21 💬
47 KCNJ11 💬 3件: Insulin secretion, GnRH secretion, Type II diabetes mellitus Repaglinide 💬 Repaglinide 4件: 6, 21, 46, 299 💬
48 ATP4A 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole 14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬
49 ATP4B 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Omeprazole 💬 Omeprazole 14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬
50 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
51 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
52 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
53 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
54 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
55 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
56 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
57 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
58 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
59 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
60 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
61 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
62 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
63 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
64 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
65 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
66 GABRQ 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Propofol 💬 Propofol 9件: 6, 21, 22, 34, 46, 70, 75, 98, 296 💬
67 GABRQ 💬 5件: Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse, Morphine addiction, Nicotine addiction Midazolam 💬 Midazolam 12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 272, 298, 299 💬
68 PTGS1 💬 5件: Arachidonic acid metabolism, Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes Flurbiprofen 💬 Flurbiprofen 3件: 13, 21, 46 💬
69 PTGS2 💬 22件: Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, VEGF signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, MicroRNAs in cancer, Small cell lung cancer Flurbiprofen 💬 Flurbiprofen 3件: 13, 21, 46 💬
70 SLC6A2 💬 1件: Synaptic vesicle cycle Bupropion 💬 Bupropion 5件: 8, 18, 21, 96, 171 💬
71 SLC6A3 💬 7件: Synaptic vesicle cycle, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Cocaine addiction, Amphetamine addiction, Alcoholism Bupropion 💬 Bupropion 5件: 8, 18, 21, 96, 171 💬
72 ABCC8 💬 3件: ABC transporters, Insulin secretion, Type II diabetes mellitus Repaglinide 💬 Repaglinide 4件: 6, 21, 46, 299 💬
73 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬
74 PDE5A 💬 3件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway Caffeine hydrate 💬 Caffeine 8件: 2, 6, 21, 46, 78, 96, 97, 265 💬