60. 再生不良性貧血 Aplastic anemia Clinical trials / Disease details

臨床試験数 : 245 / 薬物数 : 318 - (DrugBank : 86) / 標的遺伝子数 : 44 - 標的パスウェイ数 : 166

17 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05031897 (ClinicalTrials.gov)	October 25, 2021	31/8/2021	Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Und ...	A 2 Step Approach to Haploidentical Transplant Using Radiation-Based Reduced Intensity Conditioning	Acute Lymphoblastic Leukemia;Acute Myeloid Leukemia;Aplastic Anemia;Chronic Lymphocytic Leukemia;Chr ...	Procedure: Hematopoietic Cell Transplantation;Drug: Mycophenolate Mofetil;Drug: Tacrolimus;Drug: Cycl ...	Thomas Jefferson University	NULL	Recruiting	18 Years	N/A	All	67	Phase 2	United States
2	NCT03192397 (ClinicalTrials.gov)	August 9, 2017	16/6/2017	Chemotherapy, Total Body Irradiation, and Post-Transplant Cyclophosphamide in Reducing Rates of Graf ...	A Phase Ib/2 Trial of Fludarabine/Melphalan/Total Body Irradiation With Post Transplant Cyclophospha ...	Acute Myeloid Leukemia in Remission;Adult Acute Lymphoblastic Leukemia in Complete Remission;Chronic ...	Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;Drug: Cyclophosphamide;Drug: Fludarabi ...	Roswell Park Cancer Institute	NULL	Active, not recruiting	18 Years	N/A	All	35	Phase 1/Phase 2	United States
3	NCT02918292 (ClinicalTrials.gov)	July 3, 2017	27/9/2016	Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)	Optimizing Haploidentical Aplastic Anemia Transplantation (CHAMP) (BMT CTN 1502)	Severe Aplastic Anemia	Drug: Antithymocyte Globulin (ATG);Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total Body Ir ...	Medical College of Wisconsin	National Heart, Lung, and Blood Institute (NHLBI);National Cancer Institute (NCI);Blood and Marrow T ...	Completed	N/A	75 Years	All	32	Phase 2	United States
4	NCT02833805 (ClinicalTrials.gov)	September 2016	12/7/2016	NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia	A Phase II Trial of Non-Myeloablative (NMA) Conditioning and Transplantation of Partially HLA-Mismat ...	Severe Aplastic Anemia;Aplastic Anemia;Bone Marrow Failure;Immunosuppression	Drug: Thymoglobulin;Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total body irradiation;Drug: ...	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	NULL	Completed	N/A	N/A	All	21	Phase 2	United States
5	NCT02566304 (ClinicalTrials.gov)	November 13, 2015	30/9/2015	Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating P ...	A Two Step Approach to Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Pati ...	Acute Myeloid Leukemia;Acute Myeloid Leukemia in Remission;Aplastic Anemia;Chronic Myelomonocytic Le ...	Drug: Fludarabine;Radiation: Total-Body Irradiation;Biological: T Cell-Depleted Donor Lymphocyte Inf ...	Sidney Kimmel Cancer Center at Thomas Jefferson University	NULL	Recruiting	18 Years	N/A	All	35	Phase 2	United States
6	NCT01760655 (ClinicalTrials.gov)	December 24, 2012	2/1/2013	Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk ...	A Two Step Approach to Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for High ...	Acute Myeloid Leukemia With FLT3/ITD Mutation;Acute Myeloid Leukemia With Gene Mutations;Acute Myelo ...	Drug: Fludarabine phosphate;Drug: Busulfan;Radiation: Total-Body Irradiation;Biological: Therapeutic ...	Sidney Kimmel Cancer Center at Thomas Jefferson University	National Cancer Institute (NCI)	Completed	N/A	N/A	All	62	Phase 2	United States
7	NCT01659606 (ClinicalTrials.gov)	July 2012	6/8/2012	Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Con ...	Radiation- and Alkylator-free Hematopoietic Cell Transplantation for Bone Marrow Failure Due to Dysk ...	Dyskeratosis Congenita;Hoyeraal Hreidarsson Syndrome;Revesz Syndrome;Aplastic Anemia	Biological: alemtuzumab;Drug: Fludarabine;Drug: Cyclosporins;Drug: Mycophenolate mofetil;Drug: Tacrol ...	Boston Children's Hospital	Dana-Farber Cancer Institute;Children's Hospital Medical Center, Cincinnati;Children's Hospital Los ...	Active, not recruiting	30 Days	65 Years	All	40	Phase 2	United States;Norway;Sweden
8	NCT01529827 (ClinicalTrials.gov)	February 28, 2012	6/2/2012	Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral B ...	A Phase II Trial of Reduced Intensity Allogeneic Stem Cell Transplantation With Fludarabine, Melphal ...	Accelerated Phase Chronic Myelogenous Leukemia;Adult Acute Lymphoblastic Leukemia in Remission;Adult ...	Drug: fludarabine phosphate;Drug: melphalan;Radiation: total-body irradiation;Drug: tacrolimus;Drug: ...	Roswell Park Cancer Institute	NULL	Completed	3 Years	75 Years	All	94	Phase 2	United States
9	NCT01384513 (ClinicalTrials.gov)	August 4, 2011	27/6/2011	A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Mali ...	A Two Step Approach to Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Pati ...	Adult Acute Myeloid Leukemia With Inv(16)(p13;q22);Adult Acute Myeloid Leukemia With t(15;17)(q22;q1 ...	Drug: Fludarabine;Drug: Busulfan;Radiation: Total Body Irradiation (TBI);Biological: Donor Lymphocyt ...	Sidney Kimmel Cancer Center at Thomas Jefferson University	NULL	Completed	18 Years	N/A	All	40	Phase 2	United States
10	JPRN-UMIN000004264	2010/11/01	01/11/2010	A Pharmacokinetics (PK)/Phase I study of intravenous (i.v.) administration of mycophenolate mofetil( ...	A Pharmacokinetics (PK)/Phase I study of intravenous (i.v.) administration of mycophenolate mofetil( ...	Refractory hematologic disorders, including1. Acute myelogenous leukemia2. Acute lymphoblastic leuke ...	For GVHD prophylaxis, MMFis administered 4-6 h after allo-SCT at a dose of 1000 mg i.v. (diluted to ...	Kobe University Graduate School of Medicine	School of Pharmacy and Pharmaceutical Science, Mukogawa Women's University	Complete: follow-up complete	15years-old	69years-old	Male and Female	10	Phase 1	Japan

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