Mesenchymal stem cell ( DrugBank: - )

2 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	18
93	原発性胆汁性胆管炎	2

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05003921 (ClinicalTrials.gov)	December 2022	6/8/2021	Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem CellIntrathecal Injectio ...	Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem CellIntrathecal Injectio ...	Amyotrophic Lateral Sclerosis	Biological: AlloRx	The Foundation for Orthopaedics and Regenerative Medicine	NULL	Suspended	N/A	N/A	All	20	Phase 1	Antigua and Barbuda
2	NCT04681118 (ClinicalTrials.gov)	March 24, 2021	18/12/2020	Expanded Access Protocol: Repeated Administration of Nurown® (Autologous MSC-NTF Cells) for the Trea ...	Intermediate-size Patient Population Expanded Access Protocol: Repeated Administration of Nurown® (A ...	Amyotrophic Lateral Sclerosis	Biological: NurOwn (MSC-NTF cells)	Brainstorm-Cell Therapeutics	NULL	No longer available	18 Years	63 Years	All			United States
3	NCT04651855 (ClinicalTrials.gov)	December 2, 2020	30/9/2020	The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS	The Evaluation of the Effect of Wharton's Jelly Mesenchymal Stem Cells (WJMSCs) on the Immune System ...	Amyotrophic Lateral Sclerosis	Drug: Mesenchymal stem cells isolated from Wharton's jelly	Polski Bank Komorek Macierzystych JSC (PBKM)	National Center for Research and Development, Poland	Active, not recruiting	18 Years	N/A	All	20	Phase 1/Phase 2	Poland
4	EUCTR2018-004171-12-PL (EUCTR)	22/07/2020	05/09/2019	The evaluation of the effect of Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) on the immune system ...	The evaluation of the effect of Wharton’s Jelly Mesenchymal Stem Cells (WJMSCs) on the immune system ...	Amyotrophic Lateral Sclerosis MedDRA version: 21.1;Level: PT;Classification code 10002026;Term: Amyo ...	Product Name: FamC-1 INN or Proposed INN: WHARTON’S JELLY-DERIVED MESENCHYMAL STEM CELLS Other descrip ...	Polski Bank Komórek Macierzystych JSC (PBKM)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	20	Phase 1;Phase 2	Poland
5	NCT03280056 (ClinicalTrials.gov)	August 28, 2017	29/8/2017	Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients	A Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Sa ...	Amyotrophic Lateral Sclerosis (ALS)	Biological: NurOwn® (MSC-NTF cells);Other: Placebo;Other: Bone Marrow aspiration	Brainstorm-Cell Therapeutics	California Institute for Regenerative Medicine (CIRM)	Completed	18 Years	60 Years	All	263	Phase 3	United States
6	NCT04821479 (ClinicalTrials.gov)	January 1, 2016	19/10/2020	Repeated Mesenchymal Stem Cell Injections in ALS	Safety and Clinical Effects of Repeated Intrathecal Injections of Autologous Mesenchymal Stem Cells ...	Amyotrophic Lateral Sclerosis	Biological: Mesenchymal stem cells (MSC)	Hadassah Medical Organization	NULL	Completed	18 Years	65 Years	All	20	Phase 1/Phase 2	NULL
7	NCT02116634 (ClinicalTrials.gov)	May 2015	6/4/2014	Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis	Phase 1, 2 Study of Mesenchymal Stem Cells Injection in ALS (Amyotrophic Lateral Sclerosis) Patients ...	Amyotrophic Lateral Sclerosis	Biological: mesenchymal stem cell	Alzahra Hospital, Iran	NULL	Withdrawn	18 Years	60 Years	Both	0	Phase 1/Phase 2	Iran, Islamic Republic of
8	NCT02987413 (ClinicalTrials.gov)	April 28, 2015	1/7/2016	Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis Patients	Safety and Efficacy of Mesenchymal Stem Cells Escalated Application in Amyotrophic Lateral Sclerosis ...	Motor Neuron Disease	Biological: Autologous Mesenchymal stem cells (MSCs)	Hospital e Maternidade Dr. Christóvão da Gama	IEP São Lucas - Instituto de Ensino e Pesquisa;Clinica Jordy Sinapse;TECHLIFE - Centro de Tecnologia ...	Completed	18 Years	N/A	All	3	Phase 1	Brazil
9	NCT02492516 (ClinicalTrials.gov)	September 2014	24/6/2015	Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALS	Evaluation the Safety of Intravenous Injection of Adipose Derived Mesenchymal Stem Cellin Patients W ...	Amyotrophic Lateral Sclerosis	Biological: mesenchymal stem cells	Royan Institute	NULL	Completed	18 Years	55 Years	All	19	Phase 1	Iran, Islamic Republic of
10	NCT02290886 (ClinicalTrials.gov)	July 2014	9/10/2014	A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cellin Patients With ...	A Multicenter Phase I/II Clinical Trial, Randomized, Controlled With Placebo, Triple Blind to Evalua ...	Amyotrophic Lateral Sclerosis	Other: Intravenous administration of placebo;Drug: Intravenous administration of 1 million of MSC;Dr ...	Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud	Iniciativa Andaluza en Terapias Avanzadas	Completed	18 Years	N/A	All	52	Phase 1/Phase 2	Spain

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93. 原発性胆汁性胆管炎

臨床試験数 : 298 / 薬物数 : 252 - (DrugBank : 59) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 115

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04522869 (ClinicalTrials.gov)	August 10, 2019	4/9/2019	Umbilical Cord Derived Mesenchymal Stem Cell(UC -MSC) Transplantation for Children Suffering From Bi ...	Evaluation Safety and Efficacy of Umbilical Cord Derived Mesenchymal Stem Cell(UC -MSC) Transplantat ...	Primary Biliary Cirrhosis	Biological: Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation	Vinmec Research Institute of Stem Cell and Gene Technology	Children's Hospital Number 2, Ho Chi Minh City, Vietnam	Recruiting	5 Months	2 Years	All	34	Phase 1/Phase 2	Vietnam
2	NCT01440309 (ClinicalTrials.gov)	November 2011	20/9/2011	Efficacy and Safety Study of Allogenic Mesenchymal Stem Cells for Patients With Refractory Primary B ...	Phase I Clinical Trial, Randomized, Controlled, to Evaluate the Efficacy and Safety of Therapy With ...	Primary Biliary Cirrhosis	Biological: Biological: mesenchymal stem cell;Drug: ursodeoxycholic acid	Robert Chunhua Zhao, MD, PhD	Peking Union Medical College Hospital	Recruiting	18 Years	60 Years	Both	20	Phase 1	China

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