Methotrexate(MTX) ( DrugBank: Methotrexate )

1 disease

告示番号	疾患名（ページ内リンク）	臨床試験数
46	悪性関節リウマチ	8

46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03522415 (ClinicalTrials.gov)	May 28, 2018	29/4/2018	Study of Safety and Efficacy of HLX01+MTX in Patients With Rheumatoid Arthritis	A Randomized, Double-blind, Placebo-controlled, Phase III Study to Evaluate the Efficacy and Safety ...	Moderately to Severely Active Rheumatoid Arthritis	Drug: HLX01;Drug: Methotrexate(MTX)	Shanghai Henlius Biotech	NULL	Completed	18 Years	75 Years	All	275	Phase 3	China
2	ChiCTR-TRC-11001789	2011-11-14	2011-12-12	Effect of TGP combined with MTX and LEF on liver function in RA patients: Clinical study protocol	Effect of TGP combined with MTX and LEF on liver function in RA patients: Clinical study protocol	Rheumatoid Arthritis	Treatment:TGP capsules (TGP) + methotrexate (MTX) + leflunom;Control:methotrexate(MTX)+ leflunomide ...	Anhui Provincial Hospital Department of Rheumatism	NULL	Completed	18	65	Both	Treatment:140;Control:140;		China
3	NCT01347983 (ClinicalTrials.gov)	May 2011	3/5/2011	Extension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis Patien ...	Extension Study of Tocilizumab Long Term Treatment of Moderate to Severe Rheumatoid Arthritis Patien ...	Rheumatoid Arthritis	Drug: Tocilizumab+Methotrexate(MTX)	Chugai Pharma Taiwan	NULL	Completed	20 Years	75 Years	Both	72	Phase 3	Taiwan
4	NCT01258712 (ClinicalTrials.gov)	December 2010	8/12/2010	Study of Tocilizumab in Combination With Methotrexate for Treatment of Moderate to Severe Rheumatoid ...	Randomized, Placebo-controlled Study of Tocilizumab in Combination With Methotrexate for Treatment o ...	Rheumatoid Arthritis (RA)	Drug: Tocilizumab + methotrexate(MTX);Drug: Tocilizumab placebo + methotrexate(MTX)	Chugai Pharma Taiwan	NULL	Completed	20 Years	75 Years	Both	86	Phase 3	Taiwan
5	JPRN-UMIN000003615	2010/05/01	14/05/2010	Evaluation of the effectiveness of three nonbiologic DMARDs [salazosulfapyridine(SSZ), bucillamine(B ...	Evaluation of the effectiveness of three nonbiologic DMARDs [salazosulfapyridine(SSZ), bucillamine(B ...	RA(Rheumatoid Arthritis)	Using 3 DMARDs(Salazosulfapyridine, Bucillamine, and Methotrexate) for 24 months	St Luke's International Hospital	NULL	Recruiting	20years-old	80years-old	Male and Female	20	Not selected	Japan
6	EUCTR2005-006165-14-CZ (EUCTR)	18/08/2006	24/08/2006	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	Rheumatoid Arthritis MedDRA version: 8.1;Level: LLT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: MLN3897 Product Code: N/A INN or Proposed INN: N/A Other descriptive name: AVE9897 Trade N ...	Millennium Pharmaceuticals Inc	,NULL	Not Recruiting			Female: yes Male: yes	186	Phase 2	United Kingdom;Czech Republic;Netherlands
7	EUCTR2005-006165-14-NL (EUCTR)	16/08/2006	01/06/2006	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	Rheumatoid Arthritis MedDRA version: 8.1;Level: LLT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: MLN3897 Product Code: N/A INN or Proposed INN: N/A Other descriptive name: AVE9897 Trade N ...	Millennium Pharmaceuticals Inc	,NULL	Not Recruiting			Female: yes Male: yes	186	Phase 2	Czech Republic;United Kingdom;Netherlands
8	EUCTR2005-006165-14-GB (EUCTR)	03/08/2006	11/05/2006	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study of the Efficacy, Safety, and Pharmaco ...	Rheumatoid Arthritis MedDRA version: 8.1;Level: LLT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: MLN3897 Product Code: N/A INN or Proposed INN: N/A Other descriptive name: AVE9897 Trade N ...	Millennium Pharmaceuticals Inc	,NULL	Not Recruiting			Female: yes Male: yes	186	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	Czech Republic;Netherlands;United Kingdom

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