Botulinum toxin type B ( DrugBank: Botulinum toxin type B )

3 diseases

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00125203 (ClinicalTrials.gov)	July 2003	27/7/2005	Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)	A Randomized, Double-Blind, Placebo-Controlled Study of Safety and Efficacy of Botulinum Toxin Type B (Myobloc) in Sialorrhea in Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis;Sialorrhea	Drug: Botulinum toxin type B (Myobloc);Procedure: Injection of salivary glands	The University of Texas Health Science Center at San Antonio	ALS Association;University of Kansas;Carolinas MDA Neuromuscular/ALS Center-Carolinas Medical System	Completed	21 Years	85 Years	Both	20	Phase 2/Phase 3	United States

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00515437 (ClinicalTrials.gov)	July 2007	10/8/2007	A Multi-Center Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients	A Multi-Center, Randomized, Double-blind, Placebo-Controlled,Sequential Dose Escalation, Safety, Tolerability, and Preliminary Efficacy Study of MYOBLOC for the Treatment of Sialorrhea in Parkinson's Disease Patients	Drooling	Biological: Botulinum Toxin Type B (Myobloc);Biological: Matched placebo to Myobloc	Solstice Neurosciences	NULL	Completed	18 Years	85 Years	All	54	Phase 2	United States

臨床試験数 : 525 / 薬物数 : 565 - (DrugBank : 148) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 217

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000024818	2016/12/12	14/11/2016	The efficacy and safety of botulinum toxin type B on digital ulcers in patients with systemic sclerosis	The efficacy and safety of botulinum toxin type B on digital ulcers in patients with systemic sclerosis - The efficacy and safety of BTX-B on digital ulcers in patients with SSc	digital ulcers in systemic sclerosis patients	placebo subcutaneously injection into hands with digital ulcers botulinum toxin type B subcutaneously injection into hands with digital ulcers	Gunma University Hospital	NULL	Complete: follow-up complete	18years-old	Not applicable	Male and Female	20	Not selected	Japan
2	NCT03007004 (ClinicalTrials.gov)	December 12, 2016	28/12/2016	Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis	Trial to Confirm the Effect and Safety of Local Injection of Botulinum Toxin Type B Against Digital Ulcer in Systemic Sclerosis	Systemic Sclerosis Patients With Digital Ulcers	Drug: Botulinum toxin type B (2500 units / vial);Drug: Physiological saline	Gunma University	NULL	Completed	18 Years	N/A	All	10	Phase 2	Japan