Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin)
(Synonym: Ropion (TN))		5件: Digoxin,
Flurbiprofen,
Midazolam,
Montelukast,
Omeprazole		13件: D00298 ,
D00330 ,
D00455 ,
D00529 ,
D00550 ,
D00696 ,
D01207 ,
D01475 (Name: Ropion (TN)),
D02290 ,
D05028 ,
D05259 ,
D05261 ,
D08229 		25件: ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
ATP4A,
ATP4B,
CYSLTR1,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
PTGS1,
PTGS2 💬		49件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Arachidonic acid metabolism, Bile secretion, C-type lectin receptor signaling pathway, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Collecting duct acid secretion, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Insulin secretion, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Mineral absorption, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Nicotine addiction, Ovarian steroidogenesis, Oxidative phosphorylation, Oxytocin signaling pathway, Pancreatic secretion, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, Taste transduction, Thyroid hormone signaling pathway, Thyroid hormone synthesis, VEGF signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 46
2Dexmedetomidine with ropivacaine2件: Dexmedetomidine,
Ropivacaine		4件: D00514 ,
D01205 ,
D04048 (Name: Ropivacaine hydrochloride),
D08490 (Name: Ropivacaine)		8件: ADRA2A,
ADRA2B,
ADRA2C,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		5件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Neuroactive ligand-receptor interaction, Taste transduction, cGMP-PKG signaling pathway 💬1件: 70
3Dopamine Agonists (pramipexole, ropirinole)2件: Dopamine,
Pramipexole		4件: D00559 ,
D00633 ,
D05575 ,
D07870 		5件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		11件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
4FLURBIPROFEN
(Synonym: Ropion (TN))		1件: Flurbiprofen3件: D00330 ,
D01475 (Name: Ropion (TN)),
D02290 		2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬3件: 13, 21, 46
5HP-3000 (ropinirole hydrochloride patch)1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
6HP-3000(ropinirole hydrochloride patch)1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
7Magnesium with ropivacaine2件: Magnesium,
Ropivacaine		2件: D04048 (Name: Ropivacaine hydrochloride),
D08490 (Name: Ropivacaine)		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70
8Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142
(Synonym: Ropion (TN))		6件: BMS-986142,
Digoxin,
Flurbiprofen,
Midazolam,
Montelukast,
Pravastatin		11件: D00298 ,
D00330 ,
D00529 ,
D00550 ,
D00696 ,
D00893 ,
D01475 (Name: Ropion (TN)),
D02290 ,
D05028 ,
D08229 ,
D08410 		24件: ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4,
CYSLTR1,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
HMGCR,
PTGS1,
PTGS2 💬		49件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Arachidonic acid metabolism, Bile secretion, C-type lectin receptor signaling pathway, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Endocrine and other factor-regulated calcium reabsorption, GABAergic synapse, Gastric acid secretion, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Insulin secretion, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Mineral absorption, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Nicotine addiction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pancreatic secretion, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, Taste transduction, Terpenoid backbone biosynthesis, Thyroid hormone signaling pathway, Thyroid hormone synthesis, VEGF signaling pathway, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 46
9Pramipexole or ropinirole2件: Pramipexole,
Ropinirole		4件: D00559 ,
D00784 (Name: Ropinirole hydrochloride),
D05575 ,
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
10ROP----1件: 6
11ROP+L-Dopa1件: Levodopa1件: D00059 5件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		11件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
12ROPINIROLE1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 6, 74, 309
13Ropinirole (as hydrochloride)1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
14Ropinirole controlled-release (REQUIP CR) for RLS1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
15Ropinirole CR 2mg tablet1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
16Ropinirole CR 8mg tablet1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
17Ropinirole Hydrochloride1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬2件: 6, 309
18Ropinirole hydrochloride extended-release tablet1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
19Ropinirole hydrochloride extended-release tablet placebo1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
20Ropinirole hydrochloride prolonged release2件: Manganese citrate,
Ropinirole		2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
21Ropinirole immediate release1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
22Ropinirole Implant1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
23Ropinirole IR1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
24Ropinirole IR Tablets1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
25Ropinirole monotherapy1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
26Ropinirole oral product1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
27Ropinirole PR1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
28Ropinirole PR, 2mg1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
29Ropinirole PR/XR1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
30Ropinirole PR/XR Tablets1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
31Ropinirole Prolonged release1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
32Ropinirole prolonged release/extended release(PR/XR)1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
33Ropinirole XL1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
34Ropinirole XL (formerly CR)1件: Ropinirole2件: D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		3件: DRD2,
DRD3,
DRD4 💬		8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
35Ropinirole/L-dopa2件: Levodopa,
Ropinirole		3件: D00059 ,
D00784 (Name: Ropinirole hydrochloride),
D08489 (Name: Ropinirole)		5件: DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		11件: Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 6
36Ropivacaine1件: Ropivacaine2件: D04048 (Name: Ropivacaine hydrochloride),
D08490 (Name: Ropivacaine)		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬3件: 36, 46, 70
37Ropivacaine plus normal saline1件: Ropivacaine2件: D04048 (Name: Ropivacaine hydrochloride),
D08490 (Name: Ropivacaine)		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 70
38Tramadol with ropivacaine2件: Ropivacaine,
Tramadol		4件: D01355 ,
D04048 (Name: Ropivacaine hydrochloride),
D08490 (Name: Ropivacaine),
D08623 		6件: OPRM1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		6件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction 💬1件: 70