KEGG DRUG

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No.	薬物名（臨床試験情報から抽出）	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	指定難病告示番号
1	BG00002 (natalizumab) (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
2	BG00002-E (natalizumab high titer) (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
3	BG0002 (natalizumab) (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
4	Dosing Interruption of Natalizumab (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
5	NATALIZUMAB (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	5件: 13, 15, 25, 46, 96
6	Natalizumab (BG00002) (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
7	Natalizumab (NTZ) (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
8	Natalizumab (Tysabri)	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
9	Natalizumab 300 MG in 15 ML Injection (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
10	Natalizumab for IV Infusion (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
11	Natalizumab for Subcutaneous Injection (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
12	Natalizumab Injection [Tysabri]	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
13	Natalizumab IV (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
14	Natalizumab SC (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
15	Natalizumab treatment (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
16	Other: At-home natalizumab treated MS patient (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
17	Other: Natalizumab (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
18	Other: Natalizumab discontinuation (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
19	Personalized extended interval dosing of natalizumab (Synonym: Tysabri (TN))	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
20	TYSABRI	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	3件: 13, 25, 63
21	TYSABRI 300 mg concentrado para solución para perfusión	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
22	TYSABRI 300 mg concentrate for solution for infusion	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
23	TYSABRI 300 mg solution à diluer pour perfusion	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
24	TYSABRI and AVONEX	2件: Interferon beta-1a, Natalizumab (Synonym: Tysabri)	2件: D04554 , D06886 (Name: Tysabri (TN))	3件: IFNAR1, IFNAR2, ITGA4 💬	30件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, ECM-receptor interaction, Epstein-Barr virus infection, Focal adhesion, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, Influenza A, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Regulation of actin cytoskeleton, Toll-like receptor signaling pathway, Yersinia infection 💬	1件: 13
25	Tysabri ® (Natalizumab)	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
26	TYSABRI*IV 1FL 300MG 15ML	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
27	TYSABRI®	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13
28	Tysabri® (natalizumab)	1件: Natalizumab (Synonym: Tysabri)	1件: D06886 (Name: Tysabri (TN))	1件: ITGA4 💬	14件: Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Yersinia infection 💬	1件: 13