Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D01977 Gefitinib [1] 75
2 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D03455 Cetuximab [5] 34, 51, 86, 89, 331
3 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D04023 Erlotinib [1] 94
4 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D04024 Lapatinib [3] 34, 74, 75
5 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D07907 Erlotinib [1] 94
6 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08108 Lapatinib [3] 34, 74, 75
7 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11251 Icotinib [1] 34
8 EGFR [31] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D11772 Tesevatinib [1] 67
9 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00105 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
10 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00185 Estriol [2] 13, 227
11 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00289 Danazol [5] 60, 63, 64, 65, 285
12 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00554 Ethinylestradiol [4] 13, 46, 49, 299
13 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00575 Mestranol [2] 46, 49
14 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00962 Clomifene [1] 74
15 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D00966 Tamoxifen [4] 2, 86, 113, 227
16 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01161 Fulvestrant [2] 49, 86
17 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01413 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
18 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01413 Estradiol valerate [1] 65
19 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01617 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
20 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01953 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
21 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D01986 Estriol [2] 13, 227
22 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D02217 Raloxifene [1] 46
23 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D02367 Desogestrel [1] 230
24 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04061 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
25 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04063 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
26 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04064 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
27 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D04065 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
28 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D07726 Clomifene [1] 74
29 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08409 Prasterone [6] 49, 53, 83, 86, 96, 113
30 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08465 Raloxifene [1] 46
31 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D08559 Tamoxifen [4] 2, 86, 113, 227
32 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D11513 Estetrol [1] 53
33 ESR1 [5] Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Pathways in cancer, Proteoglycans in cancer D11514 Estetrol [1] 53
34 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D00105 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
35 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D00185 Estriol [2] 13, 227
36 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D00575 Mestranol [2] 46, 49
37 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D00962 Clomifene [1] 74
38 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D00966 Tamoxifen [4] 2, 86, 113, 227
39 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01161 Fulvestrant [2] 49, 86
40 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01413 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
41 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01413 Estradiol valerate [1] 65
42 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01617 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
43 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01953 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
44 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D01986 Estriol [2] 13, 227
45 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D02217 Raloxifene [1] 46
46 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D04061 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
47 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D04063 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
48 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D04064 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
49 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D04065 Estradiol [7] 13, 46, 49, 65, 76, 226, 299
50 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D07726 Clomifene [1] 74
51 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D08409 Prasterone [6] 49, 53, 83, 86, 96, 113
52 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D08465 Raloxifene [1] 46
53 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D08559 Tamoxifen [4] 2, 86, 113, 227
54 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D11513 Estetrol [1] 53
55 ESR2 [4] Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer D11514 Estetrol [1] 53
56 GABBR1 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D00241 Baclofen [7] 2, 10, 13, 18, 65, 149, 206
57 GABBR1 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D08861 Arbaclofen Placarbil [1] 13
58 GABBR1 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D09791 Arbaclofen [2] 13, 206
59 KCNJ3 [7] Retrograde endocannabinoid signaling, Glutamatergic synapse, Serotonergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D00636 Amiodarone [2] 28, 127
60 KCNJ3 [7] Retrograde endocannabinoid signaling, Glutamatergic synapse, Serotonergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D02910 Amiodarone [2] 28, 127
61 KCNJ5 [6] Retrograde endocannabinoid signaling, Serotonergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D00636 Amiodarone [2] 28, 127
62 KCNJ5 [6] Retrograde endocannabinoid signaling, Serotonergic synapse, Estrogen signaling pathway, Oxytocin signaling pathway, GnRH secretion, Morphine addiction D02910 Amiodarone [2] 28, 127
63 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00320 Fentanyl [4] 46, 70, 215, 231
64 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00729 Loperamide [2] 13, 97
65 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00836 Buprenorphine [3] 46, 70, 298
66 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00839 Hydromorphone [1] 70
67 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00842 Morphine [6] 36, 46, 70, 85, 86, 298
68 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00843 Nalbuphine [1] 85
69 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D00845 Sufentanil [2] 70, 280
70 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01177 Remifentanil [2] 6, 70
71 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01340 Naloxone [2] 6, 226
72 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01355 Tramadol [5] 46, 70, 78, 226, 271
73 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01383 Meperidine [1] 298
74 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01399 Fentanyl [4] 46, 70, 215, 231
75 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D01481 Dihydrocodeine [1] 310
76 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D02095 Naltrexone [13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
77 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D02271 Morphine [6] 36, 46, 70, 85, 86, 298
78 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D03783 Oxycodone [7] 6, 13, 46, 70, 226, 231, 298
79 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D05111 Nalmefene [1] 6
80 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D05113 Naltrexone [13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
81 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D05312 Oxycodone [7] 6, 13, 46, 70, 226, 231, 298
82 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D05462 Oxycodone [7] 6, 13, 46, 70, 226, 231, 298
83 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D05938 Sufentanil [2] 70, 280
84 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D07113 Loperamide [2] 13, 97
85 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D07132 Buprenorphine [3] 46, 70, 298
86 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D07831 Dihydrocodeine [1] 310
87 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08047 Hydromorphone [1] 70
88 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08144 Loperamide [2] 13, 97
89 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08233 Morphine [6] 36, 46, 70, 85, 86, 298
90 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08246 Nalbuphine [1] 85
91 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08249 Naloxone [2] 6, 226
92 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08323 Oxymorphone [1] 70
93 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08343 Meperidine [1] 298
94 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08473 Remifentanil [2] 6, 70
95 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08623 Tramadol [5] 46, 70, 78, 226, 271
96 OPRM1 [3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction D08639 Trimebutine [1] 51
97 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00066 Progesterone [1] 76
98 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00182 Norethisterone [4] 13, 46, 49, 299
99 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00289 Danazol [5] 60, 63, 64, 65, 285
100 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00585 Mifepristone [1] 75
101 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00950 Levonorgestrel [1] 13
102 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00951 Medroxyprogesterone acetate [6] 13, 35, 46, 49, 51, 60
103 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00952 Megestrol acetate [1] 76
104 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D00953 Norethisterone [4] 13, 46, 49, 299
105 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D01217 Dydrogesterone [1] 13
106 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D02367 Desogestrel [1] 230
107 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D05209 Norgestimate [1] 299
108 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D07222 Nomegestrol [1] 13
109 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D08166 Medroxyprogesterone acetate [6] 13, 35, 46, 49, 51, 60
110 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D08167 Megestrol acetate [1] 76
111 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D08281 Nomegestrol acetate [1] 13
112 PGR [3] Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway D09567 Ulipristal [1] 10
113 PIK3CA [74] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, GnRH secretion, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Growth hormone synthesis, secretion and action, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D11158 Leniolisib [2] 53, 65
114 PIK3CB [74] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, GnRH secretion, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Growth hormone synthesis, secretion and action, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D11158 Leniolisib [2] 53, 65
115 PIK3CD [74] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, GnRH secretion, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Growth hormone synthesis, secretion and action, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D11158 Leniolisib [2] 53, 65
116 PIK3CD [74] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, GnRH secretion, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Growth hormone synthesis, secretion and action, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Measles, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D11437 Parsaclisib [3] 35, 53, 61
117 PRKCD [11] Vascular smooth muscle contraction, NOD-like receptor signaling pathway, Fc gamma R-mediated phagocytosis, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, GnRH signaling pathway, Estrogen signaling pathway, Type II diabetes mellitus, Insulin resistance, Prion disease, Shigellosis D09671 Sotrastaurin [1] 97
118 MAP2K1 [64] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
119 MAP2K1 [64] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
120 MAP2K1 [64] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
121 MAP2K1 [64] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, Oocyte meiosis, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, TNF signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
122 MAP2K2 [55] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D09666 Selumetinib [1] 34
123 MAP2K2 [55] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10175 Trametinib [4] 2, 34, 279, 280
124 MAP2K2 [55] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10405 Cobimetinib [1] 280
125 MAP2K2 [55] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Long-term potentiation, Neurotrophin signaling pathway, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Yersinia infection, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Glioma, Prostate cancer, Thyroid cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D10604 Binimetinib [1] 34
126 RAF1 [58] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D06272 Sorafenib [2] 34, 86
127 RAF1 [58] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Focal adhesion, Gap junction, Signaling pathways regulating pluripotency of stem cells, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Long-term potentiation, Neurotrophin signaling pathway, Serotonergic synapse, Long-term depression, Regulation of actin cytoskeleton, Insulin signaling pathway, GnRH signaling pathway, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Melanogenesis, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, GnRH secretion, Growth hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Salmonella infection, Tuberculosis, Hepatitis C, Hepatitis B, Human cytomegalovirus infection, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Glioma, Prostate cancer, Melanoma, Non-small cell lung cancer, Hepatocellular carcinoma, Gastric cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer D08524 Sorafenib [2] 34, 86
128 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D00094 Tretinoin [6] 2, 62, 63, 75, 94, 231
129 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D00348 Isotretinoin [4] 36, 39, 159, 160
130 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D01418 Tamibarotene [2] 26, 96
131 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D02754 Acitretin [1] 37
132 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D02815 Alitretinoin [1] 49
133 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D04162 Fenretinide [1] 299
134 RARA [4] Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer D06543 Vitamin A [3] 13, 53, 90
135 BCL2 [31] Platinum drug resistance, NF-kappa B signaling pathway, HIF-1 signaling pathway, Sphingolipid signaling pathway, p53 signaling pathway, Protein processing in endoplasmic reticulum, PI3K-Akt signaling pathway, Necroptosis, Hedgehog signaling pathway, Focal adhesion, NOD-like receptor signaling pathway, JAK-STAT signaling pathway, Neurotrophin signaling pathway, Estrogen signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways of neurodegeneration - multiple diseases, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Hepatitis B, Measles, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, MicroRNAs in cancer, Prostate cancer, Small cell lung cancer, Gastric cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D10679 Venetoclax [1] 28
136 SRC [29] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Focal adhesion, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03252 Bosutinib [2] 2, 67
137 SRC [29] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Focal adhesion, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D03658 Dasatinib [2] 51, 85
138 SRC [29] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Focal adhesion, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D06414 Dasatinib [2] 51, 85
139 SRC [29] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Focal adhesion, Tight junction, Gap junction, Platelet activation, Neutrophil extracellular trap formation, GABAergic synapse, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Hepatitis B, Human cytomegalovirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis, Fluid shear stress and atherosclerosis D09664 Saracatinib [3] 6, 89, 272
140 GABBR2 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D00241 Baclofen [7] 2, 10, 13, 18, 65, 149, 206
141 GABBR2 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D08861 Arbaclofen Placarbil [1] 13
142 GABBR2 [6] Neuroactive ligand-receptor interaction, GABAergic synapse, Taste transduction, Estrogen signaling pathway, GnRH secretion, Morphine addiction D09791 Arbaclofen [2] 13, 206