Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D00306 Dronabinol [8] 2, 8, 13, 36, 46, 96, 271, 298
2 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05099 Nabilone [2] 6, 13
3 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D05731 Rimonabant [1] 193
4 CNR1 [3] Rap1 signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling D10915 Cannabidiol [19] 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
5 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine [3] 13, 58, 65
6 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00528 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
7 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D01453 Caffeine [9] 2, 6, 13, 21, 46, 78, 96, 97, 265
8 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D02017 Theophylline [2] 236, 299
9 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate [1] 46
10 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D04641 Istradefylline [1] 6
11 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D05711 Regadenoson [1] 58
12 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D09717 Preladenant [1] 6
13 ADORA2A [2] Rap1 signaling pathway, Vascular smooth muscle contraction D10174 Tozadenant [1] 6
14 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00045 Adenosine [3] 13, 58, 65
15 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00227 Aminophylline [1] 63
16 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D00371 Theophylline [2] 236, 299
17 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D01712 Theophylline [2] 236, 299
18 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D02769 Adenosine phosphate [1] 46
19 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D05429 Aminophylline [1] 63
20 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D06103 Theophylline [2] 236, 299
21 ADORA2B [2] Rap1 signaling pathway, Vascular smooth muscle contraction D06104 Theophylline [2] 236, 299
22 MAPK14 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
23 MAPK14 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
24 CSF1 [5] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Rheumatoid arthritis D06402 Sunitinib [2] 28, 34
25 CSF1 [5] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
26 CSF1R [4] Ras signaling pathway, Rap1 signaling pathway, Viral protein interaction with cytokine and cytokine receptor, Transcriptional misregulation in cancer D11270 Pexidartinib [1] 34
27 DRD2 [1] Rap1 signaling pathway D00059 Levodopa [8] 2, 4, 6, 17, 90, 140, 164, 201
28 DRD2 [1] Rap1 signaling pathway D00136 Haloperidol [1] 8
29 DRD2 [1] Rap1 signaling pathway D00270 Chlorpromazine [1] 254
30 DRD2 [1] Rap1 signaling pathway D00426 Risperidone [5] 8, 156, 179, 187, 206
31 DRD2 [1] Rap1 signaling pathway D00454 Olanzapine [2] 2, 8
32 DRD2 [1] Rap1 signaling pathway D00458 Quetiapine [2] 6, 13
33 DRD2 [1] Rap1 signaling pathway D00502 Pergolide [1] 6
34 DRD2 [1] Rap1 signaling pathway D00559 Pramipexole [3] 2, 6, 20
35 DRD2 [1] Rap1 signaling pathway D00560 Pimozide [1] 2
36 DRD2 [1] Rap1 signaling pathway D00633 Dopamine [4] 6, 7, 74, 299
37 DRD2 [1] Rap1 signaling pathway D00702 Buspirone [3] 6, 51, 179
38 DRD2 [1] Rap1 signaling pathway D00726 Metoclopramide [1] 51
39 DRD2 [1] Rap1 signaling pathway D00780 Bromocriptine [2] 6, 74
40 DRD2 [1] Rap1 signaling pathway D00784 Ropinirole [4] 2, 6, 74, 309
41 DRD2 [1] Rap1 signaling pathway D00789 Chlorpromazine [1] 254
42 DRD2 [1] Rap1 signaling pathway D00799 Trifluoperazine [2] 283, 284
43 DRD2 [1] Rap1 signaling pathway D00987 Cabergoline [3] 6, 74, 75
44 DRD2 [1] Rap1 signaling pathway D01044 Flupentixol [1] 97
45 DRD2 [1] Rap1 signaling pathway D01164 Aripiprazole [2] 6, 206
46 DRD2 [1] Rap1 signaling pathway D01226 Sulpiride [5] 2, 6, 17, 46, 70
47 DRD2 [1] Rap1 signaling pathway D01348 Terguride [2] 51, 86
48 DRD2 [1] Rap1 signaling pathway D01448 Trifluoperazine [2] 283, 284
49 DRD2 [1] Rap1 signaling pathway D01462 Lisuride [2] 6, 86
50 DRD2 [1] Rap1 signaling pathway D01745 Domperidone [5] 6, 13, 17, 51, 230
51 DRD2 [1] Rap1 signaling pathway D01898 Haloperidol [1] 8
52 DRD2 [1] Rap1 signaling pathway D02004 Apomorphine [3] 5, 6, 7
53 DRD2 [1] Rap1 signaling pathway D02213 Metoclopramide [1] 51
54 DRD2 [1] Rap1 signaling pathway D03165 Bromocriptine [2] 6, 74
55 DRD2 [1] Rap1 signaling pathway D03274 Chlorpromazine [1] 254
56 DRD2 [1] Rap1 signaling pathway D04034 Chlorpromazine [1] 254
57 DRD2 [1] Rap1 signaling pathway D05008 Metoclopramide [1] 51
58 DRD2 [1] Rap1 signaling pathway D05575 Pramipexole [3] 2, 6, 20
59 DRD2 [1] Rap1 signaling pathway D05768 Rotigotine [2] 6, 127
60 DRD2 [1] Rap1 signaling pathway D06623 Olanzapine [2] 2, 8
61 DRD2 [1] Rap1 signaling pathway D07305 Piribedil [1] 6
62 DRD2 [1] Rap1 signaling pathway D07309 Melperone [1] 6
63 DRD2 [1] Rap1 signaling pathway D07460 Apomorphine [3] 5, 6, 7
64 DRD2 [1] Rap1 signaling pathway D07593 Buspirone [3] 6, 51, 179
65 DRD2 [1] Rap1 signaling pathway D07868 Domperidone [5] 6, 13, 17, 51, 230
66 DRD2 [1] Rap1 signaling pathway D07870 Dopamine [4] 6, 7, 74, 299
67 DRD2 [1] Rap1 signaling pathway D08132 Lisuride [2] 6, 86
68 DRD2 [1] Rap1 signaling pathway D08339 Pergolide [1] 6
69 DRD2 [1] Rap1 signaling pathway D08456 Quetiapine [2] 6, 13
70 DRD2 [1] Rap1 signaling pathway D08489 Ropinirole [4] 2, 6, 74, 309
71 DRD2 [1] Rap1 signaling pathway D08549 Sulpiride [5] 2, 6, 17, 46, 70
72 DRD2 [1] Rap1 signaling pathway D08590 Tiapride [1] 8
73 DRD2 [1] Rap1 signaling pathway D08636 Trifluoperazine [2] 283, 284
74 DRD2 [1] Rap1 signaling pathway D09397 Pardoprunox [1] 6
75 DRD2 [1] Rap1 signaling pathway D09886 Dexpramipexole [1] 2
76 DRD2 [1] Rap1 signaling pathway D09953 Pridopidine [3] 2, 6, 8
77 DRD2 [1] Rap1 signaling pathway D09997 Cariprazine [1] 21
78 DRD2 [1] Rap1 signaling pathway D11839 Foslevodopa [1] 6
79 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D01977 Gefitinib [1] 75
80 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D03455 Cetuximab [5] 34, 51, 86, 89, 331
81 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D04023 Erlotinib [1] 94
82 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D04024 Lapatinib [3] 34, 74, 75
83 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D07907 Erlotinib [1] 94
84 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D08108 Lapatinib [3] 34, 74, 75
85 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11251 Icotinib [1] 34
86 EGFR [5] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis D11772 Tesevatinib [1] 67
87 EPHA2 [2] Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib [2] 51, 85
88 EPHA2 [2] Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib [2] 51, 85
89 FGFR1 [5] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
90 FGFR1 [5] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
91 FGFR3 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
92 FGFR3 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
93 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D05338 Palifermin [5] 13, 36, 38, 39, 65
94 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
95 FGFR2 [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton D11589 Infigratinib [1] 276
96 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib [1] 34
97 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D06402 Sunitinib [2] 28, 34
98 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
99 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib [1] 34
100 FLT1 [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib [5] 51, 85, 89, 227, 228
101 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D03218 Axitinib [1] 34
102 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D06272 Sorafenib [2] 34, 86
103 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D06402 Sunitinib [2] 28, 34
104 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib [2] 34, 86
105 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib [2] 28, 34
106 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D08881 Cediranib [1] 34
107 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
108 FLT4 [2] Ras signaling pathway, Rap1 signaling pathway D11772 Tesevatinib [1] 67
109 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00711 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
110 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
111 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00777 Amantadine [4] 6, 8, 13, 127
112 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D00848 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
113 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D02780 Acamprosate [2] 6, 206
114 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
115 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D03744 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
116 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D04905 Memantine [7] 2, 6, 8, 13, 49, 127, 205
117 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07058 Acamprosate [2] 6, 206
118 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07283 Esketamine [3] 2, 4, 70
119 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D07441 Amantadine [4] 6, 8, 13, 127
120 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
121 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D08174 Memantine [7] 2, 6, 8, 13, 49, 127, 205
122 GRIN1 [3] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia D09917 Latrepirdine [1] 8
123 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00711 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
124 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
125 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00777 Amantadine [4] 6, 8, 13, 127
126 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00848 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
127 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D02780 Acamprosate [2] 6, 206
128 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
129 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03744 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
130 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D04905 Memantine [7] 2, 6, 8, 13, 49, 127, 205
131 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
132 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
133 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
134 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
135 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine [7] 2, 6, 8, 13, 49, 127, 205
136 GRIN2A [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine [1] 8
137 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00711 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
138 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
139 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00777 Amantadine [4] 6, 8, 13, 127
140 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D00848 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
141 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D02780 Acamprosate [2] 6, 206
142 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
143 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D03744 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
144 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D04905 Memantine [7] 2, 6, 8, 13, 49, 127, 205
145 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
146 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
147 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
148 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
149 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine [7] 2, 6, 8, 13, 49, 127, 205
150 GRIN2B [4] Ras signaling pathway, Rap1 signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine [1] 8
151 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D03297 Mecasermin [6] 65, 78, 96, 168, 265, 299
152 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D04870 Mecasermin [6] 65, 78, 96, 168, 265, 299
153 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09680 Teprotumumab [1] 51
154 IGF1R [4] Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer D09925 Linsitinib [1] 232
155 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D00085 Insulin human [2] 96, 156
156 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03230 Insulin human [2] 96, 156
157 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D03250 Insulin glargine [1] 299
158 INSR [4] Ras signaling pathway, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus D04539 Insulin detemir [1] 299
159 ITGAL [5] Rap1 signaling pathway, Regulation of actin cytoskeleton, Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96
160 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D03218 Axitinib [1] 34
161 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D06272 Sorafenib [2] 34, 86
162 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D06402 Sunitinib [2] 28, 34
163 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08524 Sorafenib [2] 34, 86
164 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08552 Sunitinib [2] 28, 34
165 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D08881 Cediranib [1] 34
166 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10062 Cabozantinib [1] 34
167 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D10481 Nintedanib [5] 51, 85, 89, 227, 228
168 KDR [3] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway D11772 Tesevatinib [1] 67
169 KIT [2] Ras signaling pathway, Rap1 signaling pathway D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
170 KIT [2] Ras signaling pathway, Rap1 signaling pathway D03658 Dasatinib [2] 51, 85
171 KIT [2] Ras signaling pathway, Rap1 signaling pathway D06272 Sorafenib [2] 34, 86
172 KIT [2] Ras signaling pathway, Rap1 signaling pathway D06402 Sunitinib [2] 28, 34
173 KIT [2] Ras signaling pathway, Rap1 signaling pathway D06414 Dasatinib [2] 51, 85
174 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
175 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08524 Sorafenib [2] 34, 86
176 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08552 Sunitinib [2] 28, 34
177 KIT [2] Ras signaling pathway, Rap1 signaling pathway D08953 Nilotinib [5] 6, 8, 34, 51, 86
178 KIT [2] Ras signaling pathway, Rap1 signaling pathway D10229 Masitinib [6] 2, 5, 6, 13, 46, 96
179 KIT [2] Ras signaling pathway, Rap1 signaling pathway D11270 Pexidartinib [1] 34
180 MET [4] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer, Renal cell carcinoma D10062 Cabozantinib [1] 34
181 NGF [2] Ras signaling pathway, Rap1 signaling pathway D09387 Tanezumab [2] 226, 298
182 NGFR [3] Ras signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer D11028 Cenegermin [2] 53, 90
183 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D01441 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
184 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06402 Sunitinib [2] 28, 34
185 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08066 Imatinib [12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
186 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
187 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
188 PDGFRA [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
189 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D03658 Dasatinib [2] 51, 85
190 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06272 Sorafenib [2] 34, 86
191 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06402 Sunitinib [2] 28, 34
192 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D06414 Dasatinib [2] 51, 85
193 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08524 Sorafenib [2] 34, 86
194 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08552 Sunitinib [2] 28, 34
195 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D08953 Nilotinib [5] 6, 8, 34, 51, 86
196 PDGFRB [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10481 Nintedanib [5] 51, 85, 89, 227, 228
197 PGF [2] Ras signaling pathway, Rap1 signaling pathway D09574 Aflibercept [2] 90, 166
198 PIK3CA [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
199 PIK3CB [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
200 PIK3CD [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11158 Leniolisib [2] 53, 65
201 PIK3CD [20] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Renal cell carcinoma, Small cell lung cancer D11437 Parsaclisib [3] 35, 53, 61
202 MAPK11 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
203 MAPK11 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
204 MAPK13 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
205 MAPK13 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
206 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
207 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
208 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
209 MAP2K1 [17] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
210 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D09666 Selumetinib [1] 34
211 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
212 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10405 Cobimetinib [1] 280
213 MAP2K2 [15] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Renal cell carcinoma, Thyroid cancer D10604 Binimetinib [1] 34
214 RAF1 [14] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D06272 Sorafenib [2] 34, 86
215 RAF1 [14] Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Renal cell carcinoma D08524 Sorafenib [2] 34, 86
216 MAPK12 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
217 MAPK12 [18] Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Retrograde endocannabinoid signaling, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
218 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03252 Bosutinib [2] 2, 67
219 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D03658 Dasatinib [2] 51, 85
220 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D06414 Dasatinib [2] 51, 85
221 SRC [10] Rap1 signaling pathway, VEGF signaling pathway, Tight junction, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Shigellosis, Yersinia infection, Tuberculosis, Viral carcinogenesis D09664 Saracatinib [3] 6, 89, 272
222 BRAF [6] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D06272 Sorafenib [2] 34, 86
223 BRAF [6] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D08524 Sorafenib [2] 34, 86
224 BRAF [6] Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer D10064 Dabrafenib [1] 34
225 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
226 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D06409 Bevacizumab [9] 13, 34, 85, 86, 87, 89, 227, 280, 331
227 VEGFA [6] Ras signaling pathway, Rap1 signaling pathway, VEGF signaling pathway, Relaxin signaling pathway, Renal cell carcinoma, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
228 VEGFB [3] Ras signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway D09574 Aflibercept [2] 90, 166
229 FGF23 [3] Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton D10913 Burosumab [1] 238