Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00320	Fentanyl	[4] 46, 70, 215, 231
2	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00729	Loperamide	[2] 13, 97
3	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00836	Buprenorphine	[3] 46, 70, 298
4	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00839	Hydromorphone	[1] 70
5	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00842	Morphine	[6] 36, 46, 70, 85, 86, 298
6	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00843	Nalbuphine	[1] 85
7	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D00845	Sufentanil	[2] 70, 280
8	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D01177	Remifentanil	[2] 6, 70
9	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D01340	Naloxone	[2] 6, 226
10	OPRM1	[3] Neuroactive ligand-receptor interaction, Estrogen signaling pathway, Morphine addiction	D01355	Tramadol	[5] 46, 70, 78, 226, 271

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