Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MAPK14 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D09639 Losmapimod [2] 113, 222
2 MAPK14 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D10959 Neflamapimod [1] 8
3 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
4 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00300 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
5 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00364 Loratadine [4] 13, 46, 89, 98
6 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
7 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00480 Promethazine [1] 96
8 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00494 Promethazine [1] 96
9 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00664 Cetirizine [4] 13, 28, 35, 300
10 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00665 Chlorpheniramine [1] 14
11 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00666 Clemastine [1] 13
12 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00668 Chlorpheniramine [1] 14
13 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00669 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
14 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00671 Fexofenadine [2] 13, 46
15 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00789 Chlorpromazine [1] 254
16 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00814 Doxepin [1] 6
17 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D01172 Diphenylpyraline [1] 98
18 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D01242 Promethazine [1] 96
19 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D01627 Diphenylpyraline [1] 98
20 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D02419 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
21 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03274 Chlorpromazine [1] 254
22 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03285 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
23 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03290 Promethazine [1] 96
24 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03360 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
25 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03535 Clemastine [1] 13
26 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03693 Desloratadine [1] 13
27 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D03854 Diphenhydramine [10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
28 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D04034 Chlorpromazine [1] 254
29 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D06623 Olanzapine [2] 2, 8
30 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07398 Chlorpheniramine [1] 14
31 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07402 Levocetirizine [1] 61
32 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07407 Rupatadine [1] 46
33 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07662 Cetirizine [4] 13, 28, 35, 300
34 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07803 Chlorpheniramine [1] 14
35 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07803 Dexchlorpheniramine [2] 13, 49
36 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07862 Diphenylpyraline [1] 98
37 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07875 Doxepin [1] 6
38 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D07958 Fexofenadine [2] 13, 46
39 HRH1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D08040 Histamine [1] 13
40 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
41 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00274 Cisapride [1] 13
42 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine [1] 6
43 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00426 Risperidone [5] 8, 156, 179, 187, 206
44 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
45 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00458 Quetiapine [2] 6, 13
46 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00789 Chlorpromazine [1] 254
47 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00820 Trazodone [1] 2
48 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D01164 Aripiprazole [2] 6, 206
49 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02092 Cisapride [1] 13
50 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D03274 Chlorpromazine [1] 254
51 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D04034 Chlorpromazine [1] 254
52 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D06623 Olanzapine [2] 2, 8
53 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine [4] 140, 144, 145, 149
54 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08456 Quetiapine [2] 6, 13
55 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
56 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09645 Nelotanserin [1] 6
57 HTR2A [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D09997 Cariprazine [1] 21
58 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
59 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
60 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00789 Chlorpromazine [1] 254
61 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00820 Trazodone [1] 2
62 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D03274 Chlorpromazine [1] 254
63 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D04034 Chlorpromazine [1] 254
64 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D06623 Olanzapine [2] 2, 8
65 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine [4] 140, 144, 145, 149
66 HTR2B [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
67 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00270 Chlorpromazine [1] 254
68 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00283 Clozapine [1] 6
69 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00454 Olanzapine [2] 2, 8
70 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00789 Chlorpromazine [1] 254
71 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D00820 Trazodone [1] 2
72 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D02578 Agomelatine [1] 6
73 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D03274 Chlorpromazine [1] 254
74 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D04034 Chlorpromazine [1] 254
75 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D06623 Olanzapine [2] 2, 8
76 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D07945 Fenfluramine [4] 140, 144, 145, 149
77 HTR2C [3] Neuroactive ligand-receptor interaction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels D08626 Trazodone [1] 2
78 IL1B [26] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Malaria, Tuberculosis, Measles, Influenza A, Rheumatoid arthritis, Lipid and atherosclerosis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
79 IL1B [26] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Malaria, Tuberculosis, Measles, Influenza A, Rheumatoid arthritis, Lipid and atherosclerosis D06635 Rilonacept [4] 51, 106, 107, 266
80 IL1B [26] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Malaria, Tuberculosis, Measles, Influenza A, Rheumatoid arthritis, Lipid and atherosclerosis D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
81 IL1B [26] MAPK signaling pathway, NF-kappa B signaling pathway, Necroptosis, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Inflammatory mediator regulation of TRP channels, Non-alcoholic fatty liver disease, Type I diabetes mellitus, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Legionellosis, Yersinia infection, Leishmaniasis, Malaria, Tuberculosis, Measles, Influenza A, Rheumatoid arthritis, Lipid and atherosclerosis D09911 Gevokizumab [4] 41, 50, 56, 269
82 IL1R1 [7] MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Th17 cell differentiation, Inflammatory mediator regulation of TRP channels, Pathogenic Escherichia coli infection, Shigellosis D02934 Anakinra [19] 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
83 NGF [6] MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, PI3K-Akt signaling pathway, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels D09387 Tanezumab [2] 226, 298
84 PIK3CA [55] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Measles, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D11158 Leniolisib [2] 53, 65
85 PIK3CB [55] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Measles, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D11158 Leniolisib [2] 53, 65
86 PIK3CD [55] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Measles, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D11158 Leniolisib [2] 53, 65
87 PIK3CD [55] Inositol phosphate metabolism, Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Phosphatidylinositol signaling system, Sphingolipid signaling pathway, Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Insulin resistance, Non-alcoholic fatty liver disease, Spinocerebellar ataxia, Prion disease, Shigellosis, Salmonella infection, Yersinia infection, Measles, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Viral carcinogenesis, Proteoglycans in cancer, MicroRNAs in cancer, Renal cell carcinoma, Pancreatic cancer, Prostate cancer, Melanoma, Small cell lung cancer, Non-small cell lung cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D11437 Parsaclisib [3] 35, 53, 61
88 PRKCD [8] Vascular smooth muscle contraction, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Inflammatory mediator regulation of TRP channels, Type II diabetes mellitus, Insulin resistance, Prion disease, Shigellosis D09671 Sotrastaurin [1] 97
89 PRKCE [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Inflammatory mediator regulation of TRP channels, Type II diabetes mellitus, Insulin resistance, Shigellosis, MicroRNAs in cancer D09671 Sotrastaurin [1] 97
90 PRKCH [2] Vascular smooth muscle contraction, Inflammatory mediator regulation of TRP channels D09671 Sotrastaurin [1] 97
91 PRKCQ [9] NF-kappa B signaling pathway, Vascular smooth muscle contraction, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Inflammatory mediator regulation of TRP channels, Insulin resistance, Shigellosis, PD-L1 expression and PD-1 checkpoint pathway in cancer D09671 Sotrastaurin [1] 97
92 MAPK11 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D09639 Losmapimod [2] 113, 222
93 MAPK11 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D10959 Neflamapimod [1] 8
94 MAPK13 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D09639 Losmapimod [2] 113, 222
95 MAPK13 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D10959 Neflamapimod [1] 8
96 PTGER2 [4] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, Renin secretion, Pathways in cancer D00419 Misoprostol [3] 46, 70, 271
97 PTGER4 [4] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, Renin secretion, Pathways in cancer D00419 Misoprostol [3] 46, 70, 271
98 MAPK12 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D09639 Losmapimod [2] 113, 222
99 MAPK12 [39] MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, VEGF signaling pathway, Osteoclast differentiation, Signaling pathways regulating pluripotency of stem cells, Platelet activation, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Leukocyte transendothelial migration, Thermogenesis, Neurotrophin signaling pathway, Retrograde endocannabinoid signaling, Inflammatory mediator regulation of TRP channels, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Relaxin signaling pathway, Non-alcoholic fatty liver disease, Prion disease, Pathways of neurodegeneration - multiple diseases, Pathogenic Escherichia coli infection, Shigellosis, Salmonella infection, Pertussis, Yersinia infection, Leishmaniasis, Toxoplasmosis, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis D10959 Neflamapimod [1] 8
100 SRC [20] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D03252 Bosutinib [2] 2, 67
101 SRC [20] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D03658 Dasatinib [2] 51, 85
102 SRC [20] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D06414 Dasatinib [2] 51, 85
103 SRC [20] Rap1 signaling pathway, Mitophagy - animal, VEGF signaling pathway, Tight junction, Platelet activation, Neutrophil extracellular trap formation, Inflammatory mediator regulation of TRP channels, Regulation of actin cytoskeleton, Prolactin signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Pathogenic Escherichia coli infection, Shigellosis, Yersinia infection, Tuberculosis, Kaposi sarcoma-associated herpesvirus infection, Viral carcinogenesis, Proteoglycans in cancer, Lipid and atherosclerosis D09664 Saracatinib [3] 6, 89, 272
104 TRPV1 [2] Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels D00250 Capsaicin [5] 2, 6, 19, 86, 226