Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Endocrine resistance 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Endocrine resistance 💬
 [1] BRAF 💬 D10064 💬 Dabrafenib [1] 34 💬
3 Endocrine resistance 💬
 [2] BRAF, RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
4 Endocrine resistance 💬
 [2] BRAF, RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
5 Endocrine resistance 💬
 [1] CDK4 💬 D10688 💬 Abemaciclib [1] 34 💬
6 Endocrine resistance 💬
 [1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
7 Endocrine resistance 💬
 [1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
8 Endocrine resistance 💬
 [1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
9 Endocrine resistance 💬
 [1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
10 Endocrine resistance 💬
 [1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
11 Endocrine resistance 💬
 [2] EGFR, ERBB2 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
12 Endocrine resistance 💬
 [2] EGFR, ERBB2 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
13 Endocrine resistance 💬
 [2] EGFR, ERBB2 💬 D11772 💬 Tesevatinib [1] 67 💬
14 Endocrine resistance 💬
 [1] ESR1 💬 D00289 💬 Danazol [5] 60, 63, 64, 65, 285 💬
15 Endocrine resistance 💬
 [1] ESR1 💬 D02367 💬 Desogestrel [1] 230 💬
16 Endocrine resistance 💬
 [1] ESR1 💬 D00554 💬 Ethinylestradiol [4] 13, 46, 49, 299 💬
17 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D00962 💬 Clomifene [1] 74 💬
18 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D07726 💬 Clomifene [1] 74 💬
19 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D11513 💬 Estetrol [1] 53 💬
20 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D11514 💬 Estetrol [1] 53 💬
21 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D00105 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
22 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01413 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
23 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01617 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
24 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01953 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
25 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D04061 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
26 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D04063 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
27 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D04064 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
28 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D04065 💬 Estradiol [7] 13, 46, 49, 65, 76, 226, 299 💬
29 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01413 💬 Estradiol valerate [1] 65 💬
30 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D00185 💬 Estriol [2] 13, 227 💬
31 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01986 💬 Estriol [2] 13, 227 💬
32 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D01161 💬 Fulvestrant [2] 49, 86 💬
33 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D00575 💬 Mestranol [2] 46, 49 💬
34 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D08409 💬 Prasterone [6] 49, 53, 83, 86, 96, 113 💬
35 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D02217 💬 Raloxifene [1] 46 💬
36 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D08465 💬 Raloxifene [1] 46 💬
37 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D00966 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
38 Endocrine resistance 💬
 [2] ESR1, ESR2 💬 D08559 💬 Tamoxifen [4]  2 , 86, 113, 227 💬
39 Endocrine resistance 💬
 [1] IGF1R 💬 D09925 💬 Linsitinib [1] 232 💬
40 Endocrine resistance 💬
 [1] IGF1R 💬 D03297 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
41 Endocrine resistance 💬
 [1] IGF1R 💬 D04870 💬 Mecasermin [6] 65, 78, 96, 168, 265, 299 💬
42 Endocrine resistance 💬
 [1] IGF1R 💬 D09680 💬 Teprotumumab [1] 51 💬
43 Endocrine resistance 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
44 Endocrine resistance 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
45 Endocrine resistance 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
46 Endocrine resistance 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
47 Endocrine resistance 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
48 Endocrine resistance 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
49 Endocrine resistance 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
50 Endocrine resistance 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
51 Endocrine resistance 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
52 Endocrine resistance 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
53 Endocrine resistance 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
54 Endocrine resistance 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
55 Endocrine resistance 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
56 Endocrine resistance 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
57 Endocrine resistance 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬