Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 Shigellosis 💬
[1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Shigellosis 💬
[1] C3 💬 D11613 💬 Pegcetacoplan [3]  2 , 62, 222 💬
3 Shigellosis 💬
[1] CSF2 💬 D11343 💬 Otilimab [2] 46, 256 💬
4 Shigellosis 💬
[1] EGFR 💬 D03455 💬 Cetuximab [5] 34, 51, 86, 89, 331 💬
5 Shigellosis 💬
[1] EGFR 💬 D04023 💬 Erlotinib [1] 94 💬
6 Shigellosis 💬
[1] EGFR 💬 D07907 💬 Erlotinib [1] 94 💬
7 Shigellosis 💬
[1] EGFR 💬 D01977 💬 Gefitinib [1] 75 💬
8 Shigellosis 💬
[1] EGFR 💬 D11251 💬 Icotinib [1] 34 💬
9 Shigellosis 💬
[1] EGFR 💬 D04024 💬 Lapatinib [3] 34, 74, 75 💬
10 Shigellosis 💬
[1] EGFR 💬 D08108 💬 Lapatinib [3] 34, 74, 75 💬
11 Shigellosis 💬
[1] EGFR 💬 D11772 💬 Tesevatinib [1] 67 💬
12 Shigellosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
13 Shigellosis 💬
[1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
14 Shigellosis 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
15 Shigellosis 💬
[2] IL1B, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
16 Shigellosis 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
17 Shigellosis 💬
[4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
18 Shigellosis 💬
[4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
19 Shigellosis 💬
[1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
20 Shigellosis 💬
[1] MTOR 💬 D00753 💬 Sirolimus [41]  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
21 Shigellosis 💬
[1] MTOR 💬 D06068 💬 Temsirolimus [4] 13, 34, 89, 331 💬
22 Shigellosis 💬
[1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
23 Shigellosis 💬
[3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
24 Shigellosis 💬
[1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
25 Shigellosis 💬
[3] PRKCD, PRKCE, PRKCQ 💬 D09671 💬 Sotrastaurin [1] 97 💬
26 Shigellosis 💬
[1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
27 Shigellosis 💬
[2] ROCK1, ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
28 Shigellosis 💬
[1] ROCK2 💬 D11815 💬 Belumosudil [1] 51 💬
29 Shigellosis 💬
[1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
30 Shigellosis 💬
[1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
31 Shigellosis 💬
[1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
32 Shigellosis 💬
[1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
33 Shigellosis 💬
[1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
34 Shigellosis 💬
[1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
35 Shigellosis 💬
[1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
36 Shigellosis 💬
[1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
37 Shigellosis 💬
[1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
38 Shigellosis 💬
[1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
39 Shigellosis 💬
[1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
40 Shigellosis 💬
[1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
41 Shigellosis 💬
[1] TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
42 Shigellosis 💬
[1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬