Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 B cell receptor signaling pathway 💬
 [1] BTK 💬 D10893 💬 Acalabrutinib [2] 46, 61 💬
2 B cell receptor signaling pathway 💬
 [1] BTK 💬 D11478 💬 Branebrutinib [3] 46, 49, 53 💬
3 B cell receptor signaling pathway 💬
 [1] BTK 💬 D11457 💬 Fenebrutinib [1] 13 💬
4 B cell receptor signaling pathway 💬
 [1] BTK 💬 D10223 💬 Ibrutinib [3] 28, 60, 61 💬
5 B cell receptor signaling pathway 💬
 [1] BTK 💬 D12160 💬 Orelabrutinib [3] 13, 61, 63 💬
6 B cell receptor signaling pathway 💬
 [1] BTK 💬 D11422 💬 Zanubrutinib [2] 300, 331 💬
7 B cell receptor signaling pathway 💬
 [1] CD19 💬 D11757 💬 Inebilizumab [4] 11, 13, 51, 300 💬
8 B cell receptor signaling pathway 💬
 [1] CD22 💬 D04036 💬 Epratuzumab [1] 49 💬
9 B cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib [1] 34 💬
10 B cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib [1] 280 💬
11 B cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib [1] 34 💬
12 B cell receptor signaling pathway 💬
 [2] MAP2K1, MAP2K2 💬 D10175 💬 Trametinib [4]  2 , 34, 279, 280 💬
13 B cell receptor signaling pathway 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
14 B cell receptor signaling pathway 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
15 B cell receptor signaling pathway 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
16 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
17 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
18 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
19 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
20 B cell receptor signaling pathway 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [1] 222 💬
21 B cell receptor signaling pathway 💬
 [1] RAF1 💬 D06272 💬 Sorafenib [2] 34, 86 💬
22 B cell receptor signaling pathway 💬
 [1] RAF1 💬 D08524 💬 Sorafenib [2] 34, 86 💬
23 B cell receptor signaling pathway 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
24 B cell receptor signaling pathway 💬
 [1] SYK 💬 D09347 💬 Fostamatinib [4] 46, 49, 61, 66 💬