Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 D00294 💬 Diazoxide [2] 13, 193 💬
2 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
3 Insulin secretion 💬
 [2] ABCC8, KCNJ11 💬 D00594 💬 Repaglinide [3]  6 , 21, 299 💬
4 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00297 💬 Digitoxin [1] 299 💬
5 Insulin secretion 💬
 [4] ATP1A1, ATP1A2, ATP1A3, ATP1A4 💬 D00298 💬 Digoxin [3]  8 , 46, 210 💬
6 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
7 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
8 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
9 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine [1] 67 💬
10 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
11 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
12 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
13 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine [1]  6  💬
14 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine [2] 70, 86 💬
15 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine [2] 70, 86 💬
16 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine [2] 50, 81 💬
17 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine [1] 90 💬
18 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline [2] 58, 272 💬
19 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline [2] 58, 272 💬
20 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
21 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
22 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
23 Insulin secretion 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM3 💬 D08441 💬 Propiverine [1] 226 💬
24 Insulin secretion 💬
 [1] CHRM3 💬 D00113 💬 Atropine [2]  2 , 299 💬
25 Insulin secretion 💬
 [1] CHRM3 💬 D01077 💬 Atropine [2]  2 , 299 💬
26 Insulin secretion 💬
 [1] CHRM3 💬 D02069 💬 Atropine [2]  2 , 299 💬
27 Insulin secretion 💬
 [1] CHRM3 💬 D03011 💬 Atropine [2]  2 , 299 💬
28 Insulin secretion 💬
 [1] CHRM3 💬 D03814 💬 Atropine [2]  2 , 299 💬
29 Insulin secretion 💬
 [1] CHRM3 💬 D01000 💬 Bethanechol [1] 98 💬
30 Insulin secretion 💬
 [1] CHRM3 💬 D11383 💬 Blarcamesine [1] 156 💬
31 Insulin secretion 💬
 [1] CHRM3 💬 D00661 💬 Cevimeline [1] 53 💬
32 Insulin secretion 💬
 [1] CHRM3 💬 D07667 💬 Cevimeline [1] 53 💬
33 Insulin secretion 💬
 [1] CHRM3 💬 D00270 💬 Chlorpromazine [1] 254 💬
34 Insulin secretion 💬
 [1] CHRM3 💬 D00789 💬 Chlorpromazine [1] 254 💬
35 Insulin secretion 💬
 [1] CHRM3 💬 D03274 💬 Chlorpromazine [1] 254 💬
36 Insulin secretion 💬
 [1] CHRM3 💬 D04034 💬 Chlorpromazine [1] 254 💬
37 Insulin secretion 💬
 [1] CHRM3 💬 D01699 💬 Darifenacin [2]  6 , 13 💬
38 Insulin secretion 💬
 [1] CHRM3 💬 D03654 💬 Darifenacin [2]  6 , 13 💬
39 Insulin secretion 💬
 [1] CHRM3 💬 D07226 💬 Fesoterodine [1]  6  💬
40 Insulin secretion 💬
 [1] CHRM3 💬 D02212 💬 Ipratropium [2]  6 , 86 💬
41 Insulin secretion 💬
 [1] CHRM3 💬 D00465 💬 Oxybutynin [3]  6 , 13, 53 💬
42 Insulin secretion 💬
 [1] CHRM3 💬 D00722 💬 Oxybutynin [3]  6 , 13, 53 💬
43 Insulin secretion 💬
 [1] CHRM3 💬 D00525 💬 Pilocarpine [3]  6 , 53, 299 💬
44 Insulin secretion 💬
 [1] CHRM3 💬 D02200 💬 Pilocarpine [3]  6 , 53, 299 💬
45 Insulin secretion 💬
 [1] CHRM3 💬 D05478 💬 Pilocarpine [3]  6 , 53, 299 💬
46 Insulin secretion 💬
 [1] CHRM3 💬 D00481 💬 Propantheline [1] 26 💬
47 Insulin secretion 💬
 [1] CHRM3 💬 D00765 💬 Rocuronium [1] 296 💬
48 Insulin secretion 💬
 [1] CHRM3 💬 D00138 💬 Scopolamine [1]  2  💬
49 Insulin secretion 💬
 [1] CHRM3 💬 D01269 💬 Solifenacin [3]  6 , 13, 53 💬
50 Insulin secretion 💬
 [1] CHRM3 💬 D08522 💬 Solifenacin [3]  6 , 13, 53 💬
51 Insulin secretion 💬
 [1] CHRM3 💬 D00646 💬 Tolterodine [2] 17, 53 💬
52 Insulin secretion 💬
 [1] CHRM3 💬 D01148 💬 Tolterodine [2] 17, 53 💬
53 Insulin secretion 💬
 [1] CHRM3 💬 D00787 💬 Trihexyphenidyl [2]  5 ,  6  💬
54 Insulin secretion 💬
 [1] CHRM3 💬 D08638 💬 Trihexyphenidyl [2]  5 ,  6  💬
55 Insulin secretion 💬
 [1] CHRM3 💬 D00397 💬 Tropicamide [3]  6 , 13, 19 💬
56 Insulin secretion 💬
 [1] GLP1R 💬 D09889 💬 Dulaglutide [2] 13, 299 💬
57 Insulin secretion 💬
 [1] GLP1R 💬 D04121 💬 Exenatide [6]  6 , 17, 72, 78, 193, 233 💬
58 Insulin secretion 💬
 [1] GLP1R 💬 D06404 💬 Liraglutide [3]  6 , 75, 193 💬
59 Insulin secretion 💬
 [1] GLP1R 💬 D09729 💬 Lixisenatide [1]  6  💬
60 Insulin secretion 💬
 [1] GLP1R 💬 D10025 💬 Semaglutide [1]  6  💬
61 Insulin secretion 💬
 [1] KCNJ11 💬 D00636 💬 Amiodarone [2] 28, 127 💬
62 Insulin secretion 💬
 [1] KCNJ11 💬 D02910 💬 Amiodarone [2] 28, 127 💬
63 Insulin secretion 💬
 [1] SNAP25 💬 D00783 💬 Botulinum toxin type A [13]  2 ,  5 ,  6 ,  7 , 13, 15, 17, 36, 51, 70, 113, 149, 226 💬
64 Insulin secretion 💬
 [1] SNAP25 💬 D02735 💬 Botulinum toxin type B [4]  2 ,  6 , 13, 51 💬