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 Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト） 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"

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45 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES *   KEGG DRUG *   DrugBank   指定難病告示番号 * 
 1  Adrenergic signaling in cardiomyocytes 
 7 genes, 6 drugs (DrugBank) and 25 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 2件: ADRB1, ADRB2   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 2  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 2 drugs (DrugBank) and 19 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 3  Aldosterone synthesis and secretion 
 5 genes, 3 drugs (DrugBank) and 21 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 4  Alzheimer disease 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 5  Amphetamine addiction 
 2 genes, 1 drug (DrugBank) and 4 diseases shown 		  2件: CACNA1C, CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 6  Apelin signaling pathway 
 1 gene, 2 drugs (DrugBank) and 19 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 7  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 8  Calcium signaling pathway 
 8 genes, 6 drugs (DrugBank) and 25 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 9  cAMP signaling pathway 
 6 genes, 4 drugs (DrugBank) and 10 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 2件: ADRB1, ADRB2   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 10  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 		  1件: CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 11  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 12  Cellular senescence 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 		  1件: CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 13  cGMP-PKG signaling pathway 
 8 genes, 6 drugs (DrugBank) and 25 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 14  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 		  1件: ACE   D00624   Perindopril   2件: 167, 222 
 D03753 
 15  Cholinergic synapse 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 16  Circadian entrainment 
 2 genes, 1 drug (DrugBank) and 4 diseases shown 		  2件: CACNA1C, CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 17  Cortisol synthesis and secretion 
 5 genes, 3 drugs (DrugBank) and 21 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 18  Cushing syndrome 
 5 genes, 3 drugs (DrugBank) and 21 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 19  Dilated cardiomyopathy (DCM) 
 5 genes, 4 drugs (DrugBank) and 10 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 20  Dopaminergic synapse 
 2 genes, 1 drug (DrugBank) and 4 diseases shown 		  2件: CACNA1C, CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 21  GABAergic synapse 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 22  Gap junction 
 1 gene, 3 drugs (DrugBank) and 7 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 23  Glutamatergic synapse 
 2 genes, 1 drug (DrugBank) and 4 diseases shown 		  2件: CACNA1C, CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 24  GnRH secretion 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 25  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 26  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 27  Hypertrophic cardiomyopathy (HCM) 
 5 genes, 2 drugs (DrugBank) and 5 diseases shown 		  1件: ACE   D00624   Perindopril   2件: 167, 222 
 D03753 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 28  Insulin secretion 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 29  Long-term potentiation 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 		  1件: CACNA1C   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 30  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 31  Neuroactive ligand-receptor interaction 
 4 genes, 5 drugs (DrugBank) and 23 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 32  Oxytocin signaling pathway 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 33  Pathways in cancer 
 1 gene, 2 drugs (DrugBank) and 19 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 34  Phospholipase D signaling pathway 
 1 gene, 2 drugs (DrugBank) and 19 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 35  Regulation of lipolysis in adipocytes 
 3 genes, 3 drugs (DrugBank) and 7 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 36  Renin secretion 
 10 genes, 8 drugs (DrugBank) and 25 diseases shown 		  1件: ACE   D00624   Perindopril   2件: 167, 222 
 D03753 
 1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 1件: REN   D03208   Aliskiren   3件: 66, 167, 222 
 37  Renin-angiotensin system 
 3 genes, 4 drugs (DrugBank) and 19 diseases shown 		  1件: ACE   D00624   Perindopril   2件: 167, 222 
 D03753 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 1件: REN   D03208   Aliskiren   3件: 66, 167, 222 
 38  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 39  Salivary secretion 
 3 genes, 3 drugs (DrugBank) and 7 diseases shown 		  1件: ADRB1   D00235   Atenolol   1件: 167 
 D05127   Nebivolol   3件: 17, 113, 167 
 3件: ADRB1, ADRB2, ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 40  Serotonergic synapse 
 4 genes, 1 drug (DrugBank) and 4 diseases shown 		  4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 41  Taste transduction 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 		  1件: CACNA1C   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 42  Thermogenesis 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: ADRB3   D00483   Propranolol   5件: 6, 158, 167, 227, 278 
 D08443 
 43  Tight junction 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 		  1件: CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 44  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank) and 4 diseases shown 		  2件: CACNA1C, CACNA1D   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 
 45  Vascular smooth muscle contraction 
 5 genes, 3 drugs (DrugBank) and 21 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00619   Verapamil   4件: 96, 130, 140, 167 
 D02356 

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