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 Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト） 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"

A　B　C　D　E　F　G　H　 I 　J　K　L　M　N　O　P　Q　R　S　T　U　V　W　X　Y　Z　other

174 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES *   KEGG DRUG *   DrugBank   指定難病告示番号 * 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2  Adipocytokine signaling pathway 
 2 genes, 3 drugs (DrugBank) and 51 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 3  Adrenergic signaling in cardiomyocytes 
 6 genes, 5 drugs (DrugBank) and 24 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 4  African trypanosomiasis 
 4 genes, 2 drugs (DrugBank) and 21 diseases shown 		  4件: IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 5  AGE-RAGE signaling pathway in diabetic complications 
 13 genes, 8 drugs (DrugBank) and 38 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 5件: CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 6  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank) and 14 diseases shown 		  4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Aldosterone synthesis and secretion 
 5 genes, 7 drugs (DrugBank) and 44 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   5件: 78, 83, 113, 145, 222 
 8  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank) and 1 disease shown 		  1件: NR3C2   D10528   Aldosterone   1件: 222 
 9  Allograft rejection 
 5 genes, 4 drugs (DrugBank) and 34 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 2件: IL10, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 10  Alzheimer disease 
 7 genes, 5 drugs (DrugBank) and 60 diseases shown 		  2件: IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 11  Amoebiasis 
 7 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 12  Amphetamine addiction 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 13  AMPK signaling pathway 
 3 genes, 4 drugs (DrugBank) and 49 diseases shown 		  1件: HMGCR   D00887   Atorvastatin   17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   3件: 79, 218, 222 
 D07983 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 14  Amyotrophic lateral sclerosis (ALS) 
 10 genes, 6 drugs (DrugBank) and 60 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 15  Antifolate resistance 
 3 genes, 2 drugs (DrugBank) and 21 diseases shown 		  3件: IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 16  Antigen processing and presentation 
 1 gene, 2 drugs (DrugBank) and 21 diseases shown 		  1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 17  Apelin signaling pathway 
 2 genes, 5 drugs (DrugBank) and 50 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 18  Apoptosis 
 1 gene, 2 drugs (DrugBank) and 21 diseases shown 		  1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 19  Asthma 
 3 genes, 3 drugs (DrugBank) and 21 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: IL10, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 20  Autoimmune thyroid disease 
 4 genes, 3 drugs (DrugBank) and 28 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: IL10   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 21  Autophagy - animal 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 22  Autophagy - other 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 23  Axon guidance 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 24  B cell receptor signaling pathway 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 25  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 		  3件: ABAT, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 26  Bile secretion 
 1 gene, 2 drugs (DrugBank) and 18 diseases shown 		  1件: HMGCR   D00887   Atorvastatin   17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   3件: 79, 218, 222 
 D07983 
 27  Breast cancer 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 28  Butanoate metabolism 
 4 genes, 1 drug (DrugBank) and 14 diseases shown 		  4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 29  C-type lectin receptor signaling pathway 
 13 genes, 6 drugs (DrugBank) and 60 diseases shown 		  4件: IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 30  Calcium signaling pathway 
 10 genes, 9 drugs (DrugBank) and 74 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 1件: CD38   D10777   Daratumumab   2件: 28, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 31  cAMP signaling pathway 
 1 gene, 2 drugs (DrugBank) and 14 diseases shown 		  1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   5件: 78, 83, 113, 145, 222 
 32  Cell adhesion molecules (CAMs) 
 3 genes, 2 drugs (DrugBank) and 24 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 33  Cell cycle 
 3 genes, 1 drug (DrugBank) and 4 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 34  Cellular senescence 
 15 genes, 7 drugs (DrugBank) and 73 diseases shown 		  2件: IL1A, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 35  Central carbon metabolism in cancer 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 36  cGMP-PKG signaling pathway 
 6 genes, 7 drugs (DrugBank) and 65 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 37  Chagas disease (American trypanosomiasis) 
 13 genes, 6 drugs (DrugBank) and 26 diseases shown 		  1件: ACE   D00362   Lisinopril   5件: 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   2件: 167, 222 
 D03753 
 5件: CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 38  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank) and 10 diseases shown 		  1件: CCL2   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 39  Cholesterol metabolism 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 		  1件: PCSK9   D10557   Evolocumab   2件: 79, 222 
 40  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 41  Chronic myeloid leukemia 
 3 genes, 1 drug (DrugBank) and 4 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 42  Circadian entrainment 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 		  3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 43  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank) and 6 diseases shown 		  2件: ATP4A, ATP4B   D00355   Lansoprazole   6件: 63, 71, 98, 166, 222, 299 
 44  Colorectal cancer 
 4 genes, 2 drugs (DrugBank) and 37 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 45  Complement and coagulation cascades 
 2 genes, 2 drugs (DrugBank) and 9 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 1件: C5AR1   D11093   Avacopan   4件: 43, 44, 222, 223 
 46  Cortisol synthesis and secretion 
 5 genes, 7 drugs (DrugBank) and 44 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   5件: 78, 83, 113, 145, 222 
 47  Cushing syndrome 
 5 genes, 7 drugs (DrugBank) and 44 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   5件: 78, 83, 113, 145, 222 
 48  Cytokine-cytokine receptor interaction 
 12 genes, 6 drugs (DrugBank) and 30 diseases shown 		  6件: CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: CD40   D11357   Bleselumab   1件: 222 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 49  Cytosolic DNA-sensing pathway 
 2 genes, 1 drug (DrugBank) and 10 diseases shown 		  2件: IL1B, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 50  Dilated cardiomyopathy (DCM) 
 4 genes, 3 drugs (DrugBank) and 22 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 51  Dopaminergic synapse 
 7 genes, 4 drugs (DrugBank) and 55 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 52  Drug metabolism - other enzymes 
 2 genes, 3 drugs (DrugBank) and 36 diseases shown 		  2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 53  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 3 drugs (DrugBank) and 44 diseases shown 		  1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 54  Endocrine resistance 
 5 genes, 2 drugs (DrugBank) and 37 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 55  Endocytosis 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 56  Epithelial cell signaling in Helicobacter pylori infection 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 57  Epstein-Barr virus infection 
 8 genes, 5 drugs (DrugBank) and 23 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 58  ErbB signaling pathway 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 59  Fc epsilon RI signaling pathway 
 5 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 60  Fluid shear stress and atherosclerosis 
 8 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 61  FoxO signaling pathway 
 9 genes, 3 drugs (DrugBank) and 12 diseases shown 		  2件: IL10, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 62  GABAergic synapse 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 		  3件: ABAT, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 63  Gastric acid secretion 
 2 genes, 1 drug (DrugBank) and 6 diseases shown 		  2件: ATP4A, ATP4B   D00355   Lansoprazole   6件: 63, 71, 98, 166, 222, 299 
 64  Gastric cancer 
 4 genes, 2 drugs (DrugBank) and 37 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 65  Glioma 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 66  Glucagon signaling pathway 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 67  Glutamatergic synapse 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 68  GnRH secretion 
 3 genes, 1 drug (DrugBank) and 14 diseases shown 		  3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 69  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 70  Graft-versus-host disease 
 6 genes, 3 drugs (DrugBank) and 34 diseases shown 		  2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 4件: IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 71  Growth hormone synthesis, secretion and action 
 5 genes, 2 drugs (DrugBank) and 37 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 72  Hematopoietic cell lineage 
 7 genes, 5 drugs (DrugBank) and 55 diseases shown 		  1件: CD38   D10777   Daratumumab   2件: 28, 222 
 4件: IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: MS4A1   D02994   Rituximab   42件: 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 73  Hepatitis B 
 10 genes, 5 drugs (DrugBank) and 24 diseases shown 		  2件: IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 74  Hepatitis C 
 2 genes, 3 drugs (DrugBank) and 22 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 75  Hepatocellular carcinoma 
 4 genes, 2 drugs (DrugBank) and 37 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 76  Herpes simplex virus 1 infection 
 7 genes, 5 drugs (DrugBank) and 56 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 4件: CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 77  HIF-1 signaling pathway 
 2 genes, 2 drugs (DrugBank) and 41 diseases shown 		  1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 78  Hippo signaling pathway 
 3 genes, 1 drug (DrugBank) and 4 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 79  Human cytomegalovirus infection 
 15 genes, 8 drugs (DrugBank) and 76 diseases shown 		  4件: CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 80  Human immunodeficiency virus 1 infection 
 11 genes, 7 drugs (DrugBank) and 76 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 81  Human papillomavirus infection 
 3 genes, 4 drugs (DrugBank) and 52 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 82  Human T-cell leukemia virus 1 infection 
 13 genes, 9 drugs (DrugBank) and 60 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 2件: IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 83  Huntington disease 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 84  Hypertrophic cardiomyopathy (HCM) 
 6 genes, 5 drugs (DrugBank) and 26 diseases shown 		  1件: ACE   D00362   Lisinopril   5件: 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   2件: 167, 222 
 D03753 
 2件: IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 85  IL-17 signaling pathway 
 8 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 86  Inflammatory bowel disease (IBD) 
 8 genes, 3 drugs (DrugBank) and 22 diseases shown 		  5件: IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 87  Inflammatory mediator regulation of TRP channels 
 5 genes, 2 drugs (DrugBank) and 11 diseases shown 		  1件: IL1B   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 88  Influenza A 
 6 genes, 3 drugs (DrugBank) and 22 diseases shown 		  5件: CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 89  Insulin resistance 
 3 genes, 3 drugs (DrugBank) and 51 diseases shown 		  2件: IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 90  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 91  Intestinal immune network for IgA production 
 7 genes, 5 drugs (DrugBank) and 30 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 2件: IL10, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TGFB1   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 92  JAK-STAT signaling pathway 
 5 genes, 4 drugs (DrugBank) and 44 diseases shown 		  2件: IL10, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 93  Kaposi sarcoma-associated herpesvirus infection 
 13 genes, 8 drugs (DrugBank) and 78 diseases shown 		  1件: CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 94  Legionellosis 
 3 genes, 2 drugs (DrugBank) and 21 diseases shown 		  3件: IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 95  Leishmaniasis 
 12 genes, 5 drugs (DrugBank) and 24 diseases shown 		  4件: IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 96  Leukocyte transendothelial migration 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 97  Long-term potentiation 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 98  Longevity regulating pathway 
 2 genes, 2 drugs (DrugBank) and 39 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 99  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 100  Malaria 
 9 genes, 4 drugs (DrugBank) and 22 diseases shown 		  5件: CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: CD40   D11357   Bleselumab   1件: 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 101  MAPK signaling pathway 
 18 genes, 8 drugs (DrugBank) and 68 diseases shown 		  3件: CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 3件: IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 102  Measles 
 5 genes, 3 drugs (DrugBank) and 17 diseases shown 		  3件: IL1A, IL1B, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 103  Metabolic pathways 
 10 genes, 8 drugs (DrugBank) and 61 diseases shown 		  4件: ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 2件: ATP4A, ATP4B   D00355   Lansoprazole   6件: 63, 71, 98, 166, 222, 299 
 1件: CD38   D10777   Daratumumab   2件: 28, 222 
 1件: HMGCR   D00887   Atorvastatin   17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   3件: 79, 218, 222 
 D07983 
 2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 104  MicroRNAs in cancer 
 2 genes, 2 drugs (DrugBank) and 37 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TGFB2   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 105  mTOR signaling pathway 
 2 genes, 3 drugs (DrugBank) and 51 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 106  Natural killer cell mediated cytotoxicity 
 6 genes, 5 drugs (DrugBank) and 60 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 107  Necroptosis 
 4 genes, 3 drugs (DrugBank) and 22 diseases shown 		  3件: IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 108  Neuroactive ligand-receptor interaction 
 6 genes, 12 drugs (DrugBank) and 76 diseases shown 		  1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 1件: C5AR1   D11093   Avacopan   4件: 43, 44, 222, 223 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 D00284   Tetracosactide   5件: 78, 83, 113, 145, 222 
 1件: NR3C1   D00292   Dexamethasone   20件: 13, 16, 28, 35, 46, 53, 63, 65, 70, 74, 75, 81, 83, 84, 90, 96, 97, 222, 296, 299 
 D00975 
 D01510 
 D01615 
 D01632 
 D01948 
 D02174 
 D02591 
 D02592 
 D00407   Methylprednisolone   36件: 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 109  Neurotrophin signaling pathway 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 110  NF-kappa B signaling pathway 
 4 genes, 4 drugs (DrugBank) and 26 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 111  Nicotinate and nicotinamide metabolism 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 		  1件: CD38   D10777   Daratumumab   2件: 28, 222 
 112  NOD-like receptor signaling pathway 
 9 genes, 4 drugs (DrugBank) and 23 diseases shown 		  4件: CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 113  Non-alcoholic fatty liver disease (NAFLD) 
 5 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TGFB1   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 114  Oocyte meiosis 
 9 genes, 4 drugs (DrugBank) and 55 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 115  Osteoclast differentiation 
 16 genes, 9 drugs (DrugBank) and 62 diseases shown 		  3件: IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 2件: TGFB1, TGFB2   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 116  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank) and 6 diseases shown 		  2件: ATP4A, ATP4B   D00355   Lansoprazole   6件: 63, 71, 98, 166, 222, 299 
 117  Oxytocin signaling pathway 
 6 genes, 4 drugs (DrugBank) and 55 diseases shown 		  1件: CD38   D10777   Daratumumab   2件: 28, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 118  Pancreatic cancer 
 5 genes, 3 drugs (DrugBank) and 40 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 119  Pancreatic secretion 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 		  1件: CD38   D10777   Daratumumab   2件: 28, 222 
 120  Pathogenic Escherichia coli infection 
 7 genes, 3 drugs (DrugBank) and 22 diseases shown 		  3件: IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 121  Pathways in cancer 
 9 genes, 10 drugs (DrugBank) and 57 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 122  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 11 genes, 6 drugs (DrugBank) and 73 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 123  Pertussis 
 10 genes, 4 drugs (DrugBank) and 28 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 5件: IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 124  Phospholipase D signaling pathway 
 2 genes, 5 drugs (DrugBank) and 50 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 125  PI3K-Akt signaling pathway 
 4 genes, 4 drugs (DrugBank) and 44 diseases shown 		  1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 126  Platelet activation 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 127  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 128  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank) and 1 disease shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 129  Prion diseases 
 4 genes, 2 drugs (DrugBank) and 16 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 3件: IL1A, IL1B, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 130  Progesterone-mediated oocyte maturation 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 131  Prolactin signaling pathway 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 132  Propanoate metabolism 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 		  1件: ABAT   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 133  Prostate cancer 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 134  Proteoglycans in cancer 
 8 genes, 5 drugs (DrugBank) and 53 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 2件: TGFB1, TGFB2   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 135  Purine metabolism 
 2 genes, 3 drugs (DrugBank) and 36 diseases shown 		  2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 136  Rap1 signaling pathway 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 137  Relaxin signaling pathway 
 5 genes, 2 drugs (DrugBank) and 5 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TGFB1   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 138  Renal cell carcinoma 
 3 genes, 1 drug (DrugBank) and 4 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 139  Renin secretion 
 8 genes, 10 drugs (DrugBank) and 65 diseases shown 		  1件: ACE   D00362   Lisinopril   5件: 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   2件: 167, 222 
 D03753 
 1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: REN   D03208   Aliskiren   3件: 66, 167, 222 
 140  Renin-angiotensin system 
 4 genes, 7 drugs (DrugBank) and 24 diseases shown 		  1件: ACE   D00362   Lisinopril   5件: 46, 66, 67, 113, 222 
 D08131 
 D00624   Perindopril   2件: 167, 222 
 D03753 
 1件: AGTR1   D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 1件: REN   D03208   Aliskiren   3件: 66, 167, 222 
 141  Retrograde endocannabinoid signaling 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 142  Rheumatoid arthritis 
 11 genes, 5 drugs (DrugBank) and 36 diseases shown 		  5件: CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 143  RIG-I-like receptor signaling pathway 
 5 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 144  Salivary secretion 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 		  1件: CD38   D10777   Daratumumab   2件: 28, 222 
 145  Salmonella infection 
 7 genes, 2 drugs (DrugBank) and 11 diseases shown 		  3件: IL1A, IL1B, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 146  Shigellosis 
 7 genes, 4 drugs (DrugBank) and 52 diseases shown 		  2件: IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 147  Signaling pathways regulating pluripotency of stem cells 
 5 genes, 2 drugs (DrugBank) and 7 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 148  Sphingolipid signaling pathway 
 5 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 149  Staphylococcus aureus infection 
 3 genes, 3 drugs (DrugBank) and 18 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 1件: C5AR1   D11093   Avacopan   4件: 43, 44, 222, 223 
 1件: IL10   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 150  Systemic lupus erythematosus 
 6 genes, 5 drugs (DrugBank) and 38 diseases shown 		  1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 2件: IL10, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 151  T cell receptor signaling pathway 
 11 genes, 6 drugs (DrugBank) and 60 diseases shown 		  2件: IL10, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 152  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank) and 14 diseases shown 		  2件: GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 153  Terpenoid backbone biosynthesis 
 1 gene, 2 drugs (DrugBank) and 18 diseases shown 		  1件: HMGCR   D00887   Atorvastatin   17件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 D00892   Fluvastatin   3件: 79, 218, 222 
 D07983 
 154  TGF-beta signaling pathway 
 4 genes, 3 drugs (DrugBank) and 22 diseases shown 		  3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 155  Th1 and Th2 cell differentiation 
 11 genes, 6 drugs (DrugBank) and 56 diseases shown 		  1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 156  Th17 cell differentiation 
 15 genes, 9 drugs (DrugBank) and 74 diseases shown 		  2件: IL1B, IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 1件: TGFB1   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 157  Thermogenesis 
 6 genes, 3 drugs (DrugBank) and 40 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 158  Thyroid cancer 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 159  Thyroid hormone signaling pathway 
 1 gene, 1 drug (DrugBank) and 36 diseases shown 		  1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 160  TNF signaling pathway 
 8 genes, 3 drugs (DrugBank) and 22 diseases shown 		  4件: CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 161  Toll-like receptor signaling pathway 
 10 genes, 5 drugs (DrugBank) and 35 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 3件: IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 162  Toxoplasmosis 
 11 genes, 6 drugs (DrugBank) and 24 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: IL10, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 163  Transcriptional misregulation in cancer 
 4 genes, 4 drugs (DrugBank) and 30 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 1件: CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: IL6   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: PPARG   D00596   Rosiglitazone   5件: 46, 75, 97, 222, 265 
 D08491 
 164  Tuberculosis 
 18 genes, 8 drugs (DrugBank) and 60 diseases shown 		  5件: IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 3件: TGFB1, TGFB2, TGFB3   D09620   Fresolimumab   4件: 51, 85, 222, 274 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 165  Type I diabetes mellitus 
 7 genes, 4 drugs (DrugBank) and 45 diseases shown 		  2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 2件: GAD1, GAD2   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 3件: IL1A, IL1B, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 166  Type II diabetes mellitus 
 3 genes, 4 drugs (DrugBank) and 58 diseases shown 		  1件: CACNA1G   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 1件: MTOR   D00753   Sirolimus   36件: 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 167  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 		  1件: ABAT   D00399   Valproic Acid   14件: 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 168  Vascular smooth muscle contraction 
 1 gene, 4 drugs (DrugBank) and 24 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 D00523   Irbesartan   4件: 66, 167, 168, 222 
 D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   6件: 57, 58, 66, 75, 218, 222 
 169  VEGF signaling pathway 
 9 genes, 4 drugs (DrugBank) and 55 diseases shown 		  4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 170  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank) and 6 diseases shown 		  1件: JAK1   D10871   Filgotinib   6件: 46, 53, 96, 97, 222, 271 
 171  Viral myocarditis 
 3 genes, 2 drugs (DrugBank) and 24 diseases shown 		  1件: CD40   D11357   Bleselumab   1件: 222 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 172  Viral protein interaction with cytokine and cytokine receptor 
 5 genes, 3 drugs (DrugBank) and 24 diseases shown 		  4件: CCL2, IL10, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 1件: IL2RA   D03058   Basiliximab   7件: 2, 50, 65, 66, 97, 222, 228 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 
 173  Wnt signaling pathway 
 5 genes, 3 drugs (DrugBank) and 55 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 D09033   Voclosporin   1件: 222 
 174  Yersinia infection 
 9 genes, 3 drugs (DrugBank) and 22 diseases shown 		  5件: CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   10件: 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4件: MAPK11, MAPK12, MAPK13, MAPK14   D09639   Losmapimod   2件: 113, 222 
 1件: TNF   D02597   Adalimumab   15件: 19, 37, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 

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