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 Target Gene/Pathway（薬物標的遺伝子／パスウェイリスト） 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"

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51 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES *   KEGG DRUG *   DrugBank   指定難病告示番号 * 
 1  Adrenergic signaling in cardiomyocytes 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 		  2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 2  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 3  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 4  Alzheimer disease 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 5  Amphetamine addiction 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 6  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 7  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 8  Axon guidance 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 9  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  C-type lectin receptor signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 11  Calcium signaling pathway 
 6 genes, 2 drugs (DrugBank) and 32 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 12  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PDE4A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 13  Cellular senescence 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  cGMP-PKG signaling pathway 
 7 genes, 3 drugs (DrugBank) and 32 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 1件: PDE5A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 15  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 		  1件: ACE   D00620   Benazepril   3件: 57, 218, 224 
 D07499 
 16  Complement and coagulation cascades 
 1 gene, 1 drug (DrugBank) and 11 diseases shown 		  1件: SERPINC1   D07510   Heparin   11件: 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317 
 17  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 18  Cushing syndrome 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 19  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank) and 30 diseases shown 		  3件: PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 20  Drug metabolism - other enzymes 
 2 genes, 3 drugs (DrugBank) and 36 diseases shown 		  2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 21  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 22  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 23  Human cytomegalovirus infection 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 24  Human immunodeficiency virus 1 infection 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 25  Human T-cell leukemia virus 1 infection 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 26  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 		  1件: ACE   D00620   Benazepril   3件: 57, 218, 224 
 D07499 
 27  Kaposi sarcoma-associated herpesvirus infection 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 28  Long-term potentiation 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 29  MAPK signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 30  Metabolic pathways 
 5 genes, 5 drugs (DrugBank) and 38 diseases shown 		  1件: DHODH   D00749   Leflunomide   10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 2件: PDE4A, PDE5A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 31  Morphine addiction 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PDE4A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 32  Natural killer cell mediated cytotoxicity 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 33  Neuroactive ligand-receptor interaction 
 3 genes, 4 drugs (DrugBank) and 54 diseases shown 		  2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 1件: NR3C1   D00407   Methylprednisolone   36件: 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00473   Prednisone   44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 D08416   Prednisone acetate   6件: 35, 40, 41, 49, 162, 224 
 34  Oocyte meiosis 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 35  Osteoclast differentiation 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 36  Oxytocin signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 37  Parathyroid hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 		  1件: PDE4A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 38  Pathways in cancer 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 39  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 40  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 41  Purine metabolism 
 4 genes, 4 drugs (DrugBank) and 36 diseases shown 		  2件: IMPDH1, IMPDH2   D01392   Mizoribine   8件: 46, 49, 51, 53, 66, 94, 222, 224 
 D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 2件: PDE4A, PDE5A   D00302   Dipyridamole   5件: 46, 49, 51, 66, 224 
 42  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank) and 10 diseases shown 		  1件: DHODH   D00749   Leflunomide   10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 43  Renin secretion 
 7 genes, 3 drugs (DrugBank) and 34 diseases shown 		  1件: ACE   D00620   Benazepril   3件: 57, 218, 224 
 D07499 
 1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 44  Renin-angiotensin system 
 3 genes, 2 drugs (DrugBank) and 9 diseases shown 		  1件: ACE   D00620   Benazepril   3件: 57, 218, 224 
 D07499 
 2件: AGTR1, AGTR2   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 45  T cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 46  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 47  Th17 cell differentiation 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 48  Tuberculosis 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 49  Vascular smooth muscle contraction 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 		  1件: AGTR1   D00150   Angiotensin II   7件: 17, 19, 46, 66, 86, 222, 224 
 D02014 
 50  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 51  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank) and 30 diseases shown 		  5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 

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