| No. |
KEGG PATHWAY * On map, Yellow: Drug target, Red: Disease-related |
KEGG GENES * [Number of genes] |
KEGG DRUG * |
DrugBank |
Disease ID * [Number of diseases] |
| 1 | Adherens junction 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 2 | Adrenergic signaling in cardiomyocytes 7 genes, 5 drugs (DrugBank), 17 diseases shown |
[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| [1] SCN5A |
D01450 |
Bupivacaine |
[7] 46, 53, 70, 96, 168, 226, 298 |
| D07552 |
| D00358 |
Lidocaine |
[10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
| D02086 |
| D08127 |
| 3 | AGE-RAGE signaling pathway in diabetic complications 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 4 | Aldosterone synthesis and secretion 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 5 | AMPK signaling pathway 2 genes, 2 drugs (DrugBank), 13 diseases shown |
[1] ADRA1A |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 6 | Apelin signaling pathway 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 7 | Autophagy - animal 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 8 | Breast cancer 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 9 | Calcium signaling pathway 7 genes, 3 drugs (DrugBank), 12 diseases shown |
[6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 10 | cAMP signaling pathway 2 genes, 2 drugs (DrugBank), 9 diseases shown |
[1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [2] ADRB1, ADRB2 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| 11 | cGMP-PKG signaling pathway 10 genes, 3 drugs (DrugBank), 12 diseases shown |
[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 12 | Cortisol synthesis and secretion 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 13 | Cushing syndrome 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 14 | Cytokine-cytokine receptor interaction 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] GHR |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 15 | Dilated cardiomyopathy (DCM) 1 gene, 2 drugs (DrugBank), 9 diseases shown |
[1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| 16 | Dopaminergic synapse 1 gene, 2 drugs (DrugBank), 14 diseases shown |
[1] SCN1A |
D01450 |
Bupivacaine |
[7] 46, 53, 70, 96, 168, 226, 298 |
| D07552 |
| D00358 |
Lidocaine |
[10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
| D02086 |
| D08127 |
| 17 | EGFR tyrosine kinase inhibitor resistance 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 18 | Endocrine resistance 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 19 | Endocytosis 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 20 | Focal adhesion 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 21 | FoxO signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 22 | Gap junction 1 gene, 2 drugs (DrugBank), 9 diseases shown |
[1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| 23 | Glioma 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 24 | Growth hormone synthesis, secretion and action 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] GHR |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 25 | Hepatocellular carcinoma 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 26 | HIF-1 signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 27 | JAK-STAT signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] GHR |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 28 | Long-term depression 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 29 | Longevity regulating pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 30 | Longevity regulating pathway - multiple species 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 31 | MAPK signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 32 | Melanoma 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 33 | mTOR signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 34 | Neuroactive ligand-receptor interaction 11 genes, 4 drugs (DrugBank), 16 diseases shown |
[9] ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| [1] GHR |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 35 | Oocyte meiosis 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 36 | Ovarian steroidogenesis 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 37 | Pathways in cancer 2 genes, 2 drugs (DrugBank), 9 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| [1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 38 | Phospholipase D signaling pathway 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 39 | PI3K-Akt signaling pathway 2 genes, 1 drug (DrugBank), 6 diseases shown |
[2] GHR, IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 40 | Progesterone-mediated oocyte maturation 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 41 | Prostate cancer 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 42 | Proteoglycans in cancer 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 43 | Rap1 signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 44 | Ras signaling pathway 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 45 | Regulation of lipolysis in adipocytes 3 genes, 2 drugs (DrugBank), 9 diseases shown |
[1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [3] ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| 46 | Renin secretion 4 genes, 3 drugs (DrugBank), 12 diseases shown |
[1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| [3] ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 47 | Renin-angiotensin system 1 gene, 1 drug (DrugBank), 4 diseases shown |
[1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |
| 48 | Salivary secretion 6 genes, 2 drugs (DrugBank), 9 diseases shown |
[6] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] ADRB1 |
D07660 |
Celiprolol |
[1] 168 |
| 49 | Signaling pathways regulating pluripotency of stem cells 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 50 | Taste transduction 3 genes, 2 drugs (DrugBank), 14 diseases shown |
[3] SCN2A, SCN3A, SCN9A |
D01450 |
Bupivacaine |
[7] 46, 53, 70, 96, 168, 226, 298 |
| D07552 |
| D00358 |
Lidocaine |
[10] 6, 13, 46, 84, 86, 97, 168, 226, 231, 256 |
| D02086 |
| D08127 |
| 51 | Thermogenesis 1 gene, 1 drug (DrugBank), 9 diseases shown |
[1] ADRB3 |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| 52 | Transcriptional misregulation in cancer 1 gene, 1 drug (DrugBank), 6 diseases shown |
[1] IGF1R |
D03297 |
Mecasermin |
[6] 65, 78, 96, 168, 265, 299 |
| D04870 |
| 53 | Vascular smooth muscle contraction 4 genes, 2 drugs (DrugBank), 12 diseases shown |
[3] ADRA1A, ADRA1B, ADRA1D |
D00095 |
Epinephrine |
[9] 6, 13, 46, 86, 96, 168, 226, 231, 256 |
| D00996 |
| D02149 |
| [1] AGTR1 |
D00523 |
Irbesartan |
[4] 66, 167, 168, 222 |