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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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207 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 4 genes, 3 drugs (DrugBank), 41 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] PML, RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 2  Adherens junction 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 3  Adipocytokine signaling pathway 
 2 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 4  Adrenergic signaling in cardiomyocytes 
 5 genes, 4 drugs (DrugBank), 8 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 [1] SCN5A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 5  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 6  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 7  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 8  Alcoholism 
 10 genes, 12 drugs (DrugBank), 21 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D00454   Olanzapine   [2] 2, 8 
 D06623 
 D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 9  Aldosterone synthesis and secretion 
 5 genes, 3 drugs (DrugBank), 27 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 10  Allograft rejection 
 21 genes, 2 drugs (DrugBank), 20 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 11  Alzheimer disease 
 12 genes, 7 drugs (DrugBank), 52 diseases shown 		  [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RTN4   D10331   Ozanezumab   [1] 2 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 12  Amoebiasis 
 3 genes, 2 drugs (DrugBank), 31 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 13  Amphetamine addiction 
 17 genes, 11 drugs (DrugBank), 45 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] DRD1   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 14  AMPK signaling pathway 
 3 genes, 3 drugs (DrugBank), 45 diseases shown 		  [1] ADRA1A   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 15  Amyotrophic lateral sclerosis (ALS) 
 13 genes, 8 drugs (DrugBank), 53 diseases shown 		  [2] GRIA1, GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 16  Antifolate resistance 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 17  Antigen processing and presentation 
 21 genes, 2 drugs (DrugBank), 20 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 18  Apelin signaling pathway 
 2 genes, 4 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 19  Apoptosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 20  Arachidonic acid metabolism 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 21  Arginine and proline metabolism 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 22  Asthma 
 15 genes, 2 drugs (DrugBank), 20 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 23  Autoimmune thyroid disease 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 24  Autophagy - animal 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 25  Autophagy - other 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 26  Axon guidance 
 9 genes, 3 drugs (DrugBank), 31 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 27  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 28  Bacterial invasion of epithelial cells 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 29  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 30  Bladder cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 31  Breast cancer 
 4 genes, 3 drugs (DrugBank), 40 diseases shown 		  [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 32  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 33  C-type lectin receptor signaling pathway 
 8 genes, 4 drugs (DrugBank), 46 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 34  Caffeine metabolism 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 35  Calcium signaling pathway 
 31 genes, 14 drugs (DrugBank), 51 diseases shown 		  [2] ADORA2A, PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [8] ADRA1A, ADRA1B, ADRA1D, HRH1, HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] CHRM1, CHRM2, CHRM3, CHRM5   D00138   Scopolamine   [1] 2 
 [1] CYSLTR1   D01385   Ibudilast   [2] 2, 13 
 [2] DRD1, DRD5   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] HRH2   D00295   Cimetidine   [1] 2 
 D03503 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNNC2   D11363   Reldesemtiv   [2] 2, 3 
 36  cAMP signaling pathway 
 28 genes, 18 drugs (DrugBank), 32 diseases shown 		  [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] CHRM1, CHRM2   D00138   Scopolamine   [1] 2 
 [3] DRD1, DRD2, DRD5   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [2] DRD2, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [2] PDE3A, PDE3B   D04720   Levosimendan   [1] 2 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 37  Cell adhesion molecules (CAMs) 
 20 genes, 1 drug (DrugBank), 4 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 38  Cell cycle 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 39  Cellular senescence 
 12 genes, 3 drugs (DrugBank), 50 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 40  Central carbon metabolism in cancer 
 2 genes, 2 drugs (DrugBank), 38 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 41  cGMP-PKG signaling pathway 
 18 genes, 8 drugs (DrugBank), 40 diseases shown 		  [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 D04375   Guanabenz   [2] 2, 13 
 [2] PDE3A, PDE3B   D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 42  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 43  Chemical carcinogenesis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 44  Chemokine signaling pathway 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 45  Choline metabolism in cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 46  Cholinergic synapse 
 10 genes, 2 drugs (DrugBank), 2 diseases shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00138   Scopolamine   [1] 2 
 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5   D09569   Ezogabine   [2] 2, 144 
 47  Chronic myeloid leukemia 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 48  Circadian entrainment 
 12 genes, 7 drugs (DrugBank), 29 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 49  Cocaine addiction 
 10 genes, 13 drugs (DrugBank), 22 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] DRD1, DRD2   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D00454   Olanzapine   [2] 2, 8 
 D06623 
 D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [1] GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 50  Collecting duct acid secretion 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] ATP4A, ATP4B   D00724   Rabeprazole   [2] 2, 51 
 D08463 
 51  Colorectal cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 52  Cortisol synthesis and secretion 
 4 genes, 2 drugs (DrugBank), 24 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 53  Cushing syndrome 
 4 genes, 2 drugs (DrugBank), 24 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 54  Cytokine-cytokine receptor interaction 
 10 genes, 9 drugs (DrugBank), 69 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 55  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 56  Dopaminergic synapse 
 17 genes, 16 drugs (DrugBank), 48 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [2] DRD2, DRD3   D00560   Pimozide   [1] 2 
 [3] DRD2, DRD3, DRD4   D00454   Olanzapine   [2] 2, 8 
 D06623 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 [3] PPP3CA, PPP3CB, PPP3CC   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SCN1A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 57  Drug metabolism - cytochrome P450 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 58  Drug metabolism - other enzymes 
 3 genes, 3 drugs (DrugBank), 35 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 59  ECM-receptor interaction 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] SV2A   D00709   Levetiracetam   [4] 2, 4, 6, 13 
 60  EGFR tyrosine kinase inhibitor resistance 
 3 genes, 3 drugs (DrugBank), 46 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 61  Endocrine and other factor-regulated calcium reabsorption 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] ESR1   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 62  Endocrine resistance 
 4 genes, 3 drugs (DrugBank), 38 diseases shown 		  [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 63  Endocytosis 
 11 genes, 5 drugs (DrugBank), 16 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 64  Epithelial cell signaling in Helicobacter pylori infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 65  Epstein-Barr virus infection 
 21 genes, 2 drugs (DrugBank), 20 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 66  ErbB signaling pathway 
 3 genes, 2 drugs (DrugBank), 36 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 67  Estrogen signaling pathway 
 6 genes, 4 drugs (DrugBank), 13 diseases shown 		  [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [1] RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 68  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 69  Fluid shear stress and atherosclerosis 
 4 genes, 3 drugs (DrugBank), 32 diseases shown 		  [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 70  Focal adhesion 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 71  FoxO signaling pathway 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 72  GABAergic synapse 
 22 genes, 4 drugs (DrugBank), 26 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 73  Gap junction 
 15 genes, 7 drugs (DrugBank), 13 diseases shown 		  [2] DRD1, DRD2   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [4] DRD2, HTR2A, HTR2B, HTR2C   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 74  Gastric acid secretion 
 5 genes, 4 drugs (DrugBank), 3 diseases shown 		  [2] ATP4A, ATP4B   D00724   Rabeprazole   [2] 2, 51 
 D08463 
 [1] CHRM3   D00138   Scopolamine   [1] 2 
 [1] HRH2   D00295   Cimetidine   [1] 2 
 D03503 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 75  Gastric cancer 
 2 genes, 2 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 76  Glioma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 77  Glucagon signaling pathway 
 6 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 78  Glutamatergic synapse 
 19 genes, 7 drugs (DrugBank), 43 diseases shown 		  [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 79  Glycine, serine and threonine metabolism 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 80  GnRH secretion 
 6 genes, 3 drugs (DrugBank), 21 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 81  GnRH signaling pathway 
 2 genes, 2 drugs (DrugBank), 6 diseases shown 		  [1] GNRHR   D00989   Leuprolide   [5] 1, 2, 3, 51, 76 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 82  Graft-versus-host disease 
 21 genes, 2 drugs (DrugBank), 20 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 83  Growth hormone synthesis, secretion and action 
 2 genes, 2 drugs (DrugBank), 50 diseases shown 		  [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 84  Hematopoietic cell lineage 
 22 genes, 10 drugs (DrugBank), 60 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 85  Hepatitis B 
 2 genes, 2 drugs (DrugBank), 19 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 86  Hepatitis C 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 87  Hepatocellular carcinoma 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 88  Herpes simplex virus 1 infection 
 24 genes, 5 drugs (DrugBank), 49 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 89  HIF-1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 90  Histidine metabolism 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 91  Human cytomegalovirus infection 
 19 genes, 9 drugs (DrugBank), 72 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 92  Human immunodeficiency virus 1 infection 
 13 genes, 4 drugs (DrugBank), 58 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 93  Human papillomavirus infection 
 9 genes, 4 drugs (DrugBank), 50 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 94  Human T-cell leukemia virus 1 infection 
 31 genes, 6 drugs (DrugBank), 49 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [2] IL1R1, IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 95  Huntington disease 
 3 genes, 5 drugs (DrugBank), 28 diseases shown 		  [2] GRIN1, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 96  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 97  IL-17 signaling pathway 
 2 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 98  Inflammatory bowel disease (IBD) 
 16 genes, 3 drugs (DrugBank), 20 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 99  Inflammatory mediator regulation of TRP channels 
 7 genes, 4 drugs (DrugBank), 22 diseases shown 		  [4] HRH1, HTR2A, HTR2B, HTR2C   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 100  Influenza A 
 16 genes, 3 drugs (DrugBank), 23 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 101  Insulin resistance 
 2 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 102  Insulin secretion 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] CHRM3   D00138   Scopolamine   [1] 2 
 [1] SNAP25   D02735   Botulinum Toxin Type B   [3] 2, 6, 51 
 D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 103  Insulin signaling pathway 
 2 genes, 4 drugs (DrugBank), 39 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 104  Intestinal immune network for IgA production 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 105  JAK-STAT signaling pathway 
 8 genes, 8 drugs (DrugBank), 76 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 106  Kaposi sarcoma-associated herpesvirus infection 
 14 genes, 5 drugs (DrugBank), 54 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 107  Legionellosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 108  Leishmaniasis 
 16 genes, 3 drugs (DrugBank), 26 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 109  Leukocyte transendothelial migration 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 110  Long-term depression 
 3 genes, 3 drugs (DrugBank), 9 diseases shown 		  [3] GRIA1, GRIA2, GRIA3   D08964   Perampanel   [3] 2, 6, 144 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 D02696   Talampanel   [2] 2, 6 
 111  Long-term potentiation 
 12 genes, 7 drugs (DrugBank), 43 diseases shown 		  [2] GRIA1, GRIA2   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 112  Longevity regulating pathway 
 2 genes, 2 drugs (DrugBank), 44 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 113  Longevity regulating pathway - multiple species 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 114  Malaria 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 115  MAPK signaling pathway 
 11 genes, 5 drugs (DrugBank), 59 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 116  Measles 
 3 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 117  Melanogenesis 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 118  Metabolic pathways 
 21 genes, 11 drugs (DrugBank), 55 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [2] ATP4A, ATP4B   D00724   Rabeprazole   [2] 2, 51 
 D08463 
 [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] PDE3A, PDE3B   D04720   Levosimendan   [1] 2 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 119  MicroRNAs in cancer 
 4 genes, 4 drugs (DrugBank), 40 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] ROCK1   D07941   Fasudil   [1] 2 
 120  Mitophagy - animal 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 121  Morphine addiction 
 28 genes, 7 drugs (DrugBank), 19 diseases shown 		  [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] DRD1   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [2] PDE3A, PDE3B   D04720   Levosimendan   [1] 2 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 122  mTOR signaling pathway 
 2 genes, 2 drugs (DrugBank), 46 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 123  Natural killer cell mediated cytotoxicity 
 11 genes, 3 drugs (DrugBank), 41 diseases shown 		  [5] HLA-A, HLA-B, HLA-C, HLA-E, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 124  Necroptosis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 125  Neuroactive ligand-receptor interaction 
 66 genes, 29 drugs (DrugBank), 94 diseases shown 		  [2] ADORA1, ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [11] ADRA1A, ADRA1B, ADRA1D, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [3] ADRA2A, ADRA2B, ADRA2C   D00514   Dexmedetomidine   [11] 2, 4, 6, 21, 34, 70, 113, 212, 215, 226, 280 
 D01205 
 D04375   Guanabenz   [2] 2, 13 
 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00138   Scopolamine   [1] 2 
 [2] CNR1, CNR2   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 [2] CYSLTR1, PTGIR   D01385   Ibudilast   [2] 2, 13 
 [5] DRD1, DRD2, DRD3, DRD4, DRD5   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [2] DRD2, DRD3   D00560   Pimozide   [1] 2 
 [3] DRD2, DRD3, DRD4   D00559   Pramipexole   [2] 2, 6 
 D05575 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] GNRHR   D00989   Leuprolide   [5] 1, 2, 3, 51, 76 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 [1] HRH2   D00295   Cimetidine   [1] 2 
 D03503 
 [1] MC2R   D00146   Corticotropin   [12] 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 [1] NR3C1   D00244   Betamethasone   [6] 2, 46, 65, 90, 96, 235 
 D00972 
 D01357 
 D01402 
 D01637 
 D02032 
 D02286 
 D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 [1] TRPV1   D00250   Capsaicin   [6] 2, 6, 19, 86, 113, 226 
 126  Neurotrophin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 127  NF-kappa B signaling pathway 
 3 genes, 3 drugs (DrugBank), 36 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 128  Nicotine addiction 
 25 genes, 7 drugs (DrugBank), 21 diseases shown 		  [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D02696   Talampanel   [2] 2, 6 
 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 129  NOD-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 130  Non-alcoholic fatty liver disease (NAFLD) 
 2 genes, 2 drugs (DrugBank), 29 diseases shown 		  [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 131  Non-small cell lung cancer 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 132  Olfactory transduction 
 2 genes, 1 drug (DrugBank), 6 diseases shown 		  [2] PDE1B, PDE2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 133  Oocyte meiosis 
 6 genes, 2 drugs (DrugBank), 34 diseases shown 		  [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 134  Osteoclast differentiation 
 8 genes, 4 drugs (DrugBank), 54 diseases shown 		  [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 135  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank), 9 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 136  Oxidative phosphorylation 
 2 genes, 1 drug (DrugBank), 2 diseases shown 		  [2] ATP4A, ATP4B   D00724   Rabeprazole   [2] 2, 51 
 D08463 
 137  Oxytocin signaling pathway 
 9 genes, 4 drugs (DrugBank), 37 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 138  Pancreatic cancer 
 1 gene, 1 drug (DrugBank), 36 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 139  Pancreatic secretion 
 2 genes, 2 drugs (DrugBank), 2 diseases shown 		  [1] CHRM3   D00138   Scopolamine   [1] 2 
 [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 140  Parathyroid hormone synthesis, secretion and action 
 4 genes, 2 drugs (DrugBank), 7 diseases shown 		  [4] PDE4A, PDE4B, PDE4C, PDE4D   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 D01385   Ibudilast   [2] 2, 13 
 141  Parkinson disease 
 3 genes, 6 drugs (DrugBank), 12 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] DRD1, DRD2   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 [1] DRD2   D00454   Olanzapine   [2] 2, 8 
 D06623 
 D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 142  Pathogenic Escherichia coli infection 
 14 genes, 5 drugs (DrugBank), 34 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 143  Pathways in cancer 
 19 genes, 15 drugs (DrugBank), 78 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [3] PML, RARA, RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 144  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 6 genes, 2 drugs (DrugBank), 49 diseases shown 		  [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 145  Peroxisome 
 1 gene, 1 drug (DrugBank), 3 diseases shown 		  [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 146  Pertussis 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 147  Phagosome 
 29 genes, 2 drugs (DrugBank), 8 diseases shown 		  [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D00570   Colchicine   [5] 2, 42, 56, 93, 266 
 148  Phenylalanine metabolism 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 149  Phospholipase D signaling pathway 
 2 genes, 2 drugs (DrugBank), 38 diseases shown 		  [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 150  PI3K-Akt signaling pathway 
 11 genes, 10 drugs (DrugBank), 77 diseases shown 		  [2] CHRM1, CHRM2   D00138   Scopolamine   [1] 2 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 D03247   Lenograstim   [3] 2, 57, 65 
 [1] EPOR   D03231   Erythropoietin   [9] 2, 6, 13, 22, 46, 47, 70, 95, 96 
 [1] GHR   D02691   Somatotropin   [18] 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 151  Platelet activation 
 4 genes, 3 drugs (DrugBank), 3 diseases shown 		  [1] PTGIR   D01385   Ibudilast   [2] 2, 13 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 152  PPAR signaling pathway 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 153  Primary immunodeficiency 
 1 gene, 1 drug (DrugBank), 4 diseases shown 		  [1] IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 154  Progesterone-mediated oocyte maturation 
 1 gene, 3 drugs (DrugBank), 7 diseases shown 		  [1] PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 155  Prolactin signaling pathway 
 3 genes, 2 drugs (DrugBank), 5 diseases shown 		  [2] ESR1, ESR2   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 156  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 157  Prostate cancer 
 3 genes, 3 drugs (DrugBank), 51 diseases shown 		  [1] AR   D00075   Testosterone   [7] 1, 2, 3, 13, 78, 113, 265 
 D00957 
 D00958 
 D00959 
 D06085 
 D06087 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 158  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 159  Proteoglycans in cancer 
 6 genes, 5 drugs (DrugBank), 47 diseases shown 		  [1] ESR1   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 160  Purine metabolism 
 12 genes, 6 drugs (DrugBank), 38 diseases shown 		  [2] IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   [32] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   [34] 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] PDE3A, PDE3B   D04720   Levosimendan   [1] 2 
 [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D01385   Ibudilast   [2] 2, 13 
 [1] XDH   D01206   Febuxostat   [3] 2, 6, 13 
 161  Rap1 signaling pathway 
 8 genes, 14 drugs (DrugBank), 31 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 [1] DRD2   D09886   Dexpramipexole   [1] 2 
 D00059   Levodopa   [7] 2, 4, 6, 17, 90, 164, 201 
 D00454   Olanzapine   [2] 2, 8 
 D06623 
 D00560   Pimozide   [1] 2 
 D00559   Pramipexole   [2] 2, 6 
 D05575 
 [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 162  Ras signaling pathway 
 5 genes, 6 drugs (DrugBank), 19 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [3] GRIN1, GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [1] KIT   D10229   Masitinib   [6] 2, 5, 6, 13, 46, 96 
 163  Regulation of actin cytoskeleton 
 8 genes, 3 drugs (DrugBank), 2 diseases shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00138   Scopolamine   [1] 2 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 164  Regulation of lipolysis in adipocytes 
 3 genes, 4 drugs (DrugBank), 13 diseases shown 		  [2] ADORA1, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [1] PDE3B   D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 165  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] SRC   D03252   Bosutinib   [2] 2, 67 
 166  Renin secretion 
 9 genes, 4 drugs (DrugBank), 32 diseases shown 		  [4] ADORA1, PDE1B, PDE3A, PDE3B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] PDE3A, PDE3B   D01385   Ibudilast   [2] 2, 13 
 D04720   Levosimendan   [1] 2 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 167  Retrograde endocannabinoid signaling 
 22 genes, 7 drugs (DrugBank), 25 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [4] GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   [3] 2, 6, 144 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 D02696   Talampanel   [2] 2, 6 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 168  Rheumatoid arthritis 
 15 genes, 2 drugs (DrugBank), 20 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 169  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 170  Salivary secretion 
 4 genes, 2 drugs (DrugBank), 2 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] CHRM3   D00138   Scopolamine   [1] 2 
 171  Salmonella infection 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 172  Serotonergic synapse 
 11 genes, 6 drugs (DrugBank), 21 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [3] GABRB1, GABRB2, GABRB3   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [4] HTR2A, HTR2B, HTR2C, HTR6   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SLC6A4   D02567   Escitalopram   [3] 2, 6, 13 
 D07704 
 D07913 
 173  Shigellosis 
 7 genes, 5 drugs (DrugBank), 55 diseases shown 		  [2] ABL1, SRC   D03252   Bosutinib   [2] 2, 67 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 174  Small cell lung cancer 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] RARB   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 175  Sphingolipid signaling pathway 
 5 genes, 4 drugs (DrugBank), 24 diseases shown 		  [1] ADORA1   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] S1PR1   D10001   Fingolimod   [4] 2, 13, 14, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 176  Staphylococcus aureus infection 
 14 genes, 1 drug (DrugBank), 4 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 177  Synaptic vesicle cycle 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] SLC6A4   D02567   Escitalopram   [3] 2, 6, 13 
 D07704 
 D07913 
 [1] SNAP25   D02735   Botulinum Toxin Type B   [3] 2, 6, 51 
 D00783   Botulinum toxin type A   [13] 2, 5, 6, 7, 13, 15, 17, 36, 51, 70, 113, 149, 226 
 178  Systemic lupus erythematosus 
 17 genes, 6 drugs (DrugBank), 32 diseases shown 		  [2] GRIN2A, GRIN2B   D00848   Dextromethorphan   [9] 2, 6, 8, 13, 46, 78, 96, 97, 156 
 D03742 
 D03744 
 D07283   Esketamine   [3] 2, 4, 70 
 D04905   Memantine   [7] 2, 6, 8, 13, 49, 127, 205 
 D08174 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 179  T cell receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 40 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 180  Taste transduction 
 13 genes, 7 drugs (DrugBank), 18 diseases shown 		  [1] CHRM3   D00138   Scopolamine   [1] 2 
 [2] GABBR1, GABBR2   D00241   Baclofen   [5] 2, 10, 13, 18, 149 
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D00550   Midazolam   [10] 2, 3, 6, 13, 46, 70, 96, 97, 231, 298 
 D00696 
 D05028 
 [1] PDE1B   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] SCN2A, SCN3A, SCN9A   D00639   Mexiletine   [5] 1, 2, 10, 113, 114 
 D08215 
 D00642   Quinidine   [3] 2, 8, 13 
 D00643 
 D02272 
 D08458 
 [2] SCN3A, SCN9A   D07299   Lacosamide   [3] 2, 46, 149 
 181  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 182  TGF-beta signaling pathway 
 2 genes, 2 drugs (DrugBank), 18 diseases shown 		  [1] ROCK1   D07941   Fasudil   [1] 2 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 183  Th1 and Th2 cell differentiation 
 22 genes, 4 drugs (DrugBank), 31 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 184  Th17 cell differentiation 
 26 genes, 8 drugs (DrugBank), 66 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] IL1R1   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 185  Thermogenesis 
 3 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] CNR1   D10915   Cannabidiol   [14] 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D00306   Dronabinol   [5] 2, 13, 46, 271, 298 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 186  Thyroid cancer 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 187  Thyroid hormone signaling pathway 
 3 genes, 3 drugs (DrugBank), 38 diseases shown 		  [1] ESR1   D00966   Tamoxifen   [4] 2, 86, 113, 227 
 D08559 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 188  Tight junction 
 3 genes, 2 drugs (DrugBank), 2 diseases shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 189  TNF signaling pathway 
 2 genes, 2 drugs (DrugBank), 24 diseases shown 		  [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 190  Toll-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 18 diseases shown 		  [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 191  Toxoplasmosis 
 15 genes, 2 drugs (DrugBank), 20 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 192  Transcriptional misregulation in cancer 
 6 genes, 7 drugs (DrugBank), 37 diseases shown 		  [1] GRIA3   D08964   Perampanel   [3] 2, 6, 144 
 D00775   Riluzole   [7] 2, 3, 5, 8, 13, 17, 206 
 D02696   Talampanel   [2] 2, 6 
 [1] IL1R2   D02934   Anakinra   [17] 2, 13, 15, 19, 37, 41, 46, 49, 50, 56, 65, 84, 86, 106, 107, 266, 299 
 [1] IL2RB   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [2] PML, RARA   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 [1] PPARG   D00945   Pioglitazone   [17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 
 D08378 
 193  Tryptophan metabolism 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 194  Tuberculosis 
 21 genes, 4 drugs (DrugBank), 42 diseases shown 		  [14] HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 195  Type I diabetes mellitus 
 23 genes, 3 drugs (DrugBank), 31 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 196  Type II diabetes mellitus 
 3 genes, 3 drugs (DrugBank), 53 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] MTOR   D00753   Sirolimus   [36] 2, 13, 15, 17, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 85, 86, 89, 96, 98, 137, 157, 158, 192, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 197  Tyrosine metabolism 
 2 genes, 2 drugs (DrugBank), 9 diseases shown 		  [1] DDC   D00558   Carbidopa   [8] 2, 4, 6, 13, 17, 90, 164, 201 
 [1] MAOB   D02562   Rasagiline   [4] 2, 5, 6, 17 
 D08469 
 D10829 
 198  Ubiquitin mediated proteolysis 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] PML   D00094   Tretinoin   [5] 2, 63, 75, 94, 231 
 199  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 200  Vascular smooth muscle contraction 
 7 genes, 4 drugs (DrugBank), 8 diseases shown 		  [1] ADORA2A   D00528   Caffeine   [6] 2, 6, 46, 78, 96, 97 
 D01453 
 [3] ADRA1A, ADRA1B, ADRA1D   D00454   Olanzapine   [2] 2, 8 
 D06623 
 [1] PTGIR   D01385   Ibudilast   [2] 2, 13 
 [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 201  VEGF signaling pathway 
 7 genes, 3 drugs (DrugBank), 37 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] PTGS2   D00567   Celecoxib   [9] 2, 3, 34, 46, 70, 89, 96, 161, 271 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 202  Vibrio cholerae infection 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] KCNQ1   D09569   Ezogabine   [2] 2, 144 
 203  Viral carcinogenesis 
 7 genes, 2 drugs (DrugBank), 5 diseases shown 		  [6] HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 204  Viral myocarditis 
 21 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ABL1   D03252   Bosutinib   [2] 2, 67 
 [20] HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G   D04318   Glatiramer   [4] 2, 13, 96, 156 
 205  Viral protein interaction with cytokine and cytokine receptor 
 5 genes, 4 drugs (DrugBank), 32 diseases shown 		  [1] IL2RA   D03058   Basiliximab   [7] 2, 50, 65, 66, 97, 222, 228 
 [3] IL2RA, IL2RB, IL2RG   D00748   Aldesleukin   [4] 2, 49, 65, 97 
 [1] IL6R   D02596   Tocilizumab   [16] 2, 13, 40, 41, 43, 46, 50, 51, 53, 54, 55, 86, 107, 266, 271, 331 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 
 206  Wnt signaling pathway 
 6 genes, 2 drugs (DrugBank), 30 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00107   Tacrolimus   [30] 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 [1] ROCK2   D07941   Fasudil   [1] 2 
 207  Yersinia infection 
 4 genes, 3 drugs (DrugBank), 19 diseases shown 		  [2] ROCK1, ROCK2   D07941   Fasudil   [1] 2 
 [1] SRC   D03252   Bosutinib   [2] 2, 67 
 [1] TNF   D00754   Thalidomide   [18] 2, 16, 20, 28, 49, 51, 53, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 331 

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