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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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13 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Calcium signaling pathway 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 2  cAMP signaling pathway 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 3  cGMP-PKG signaling pathway 
 3 genes, 3 drugs (DrugBank), 21 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 4  Melanogenesis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 5  Metabolic pathways 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 6  Neuroactive ligand-receptor interaction 
 2 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 7  Oocyte meiosis 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] AR   D00462   Oxandrolone   [2] 211, 285 
 8  Pathways in cancer 
 3 genes, 3 drugs (DrugBank), 11 diseases shown 		  [1] AR   D00462   Oxandrolone   [2] 211, 285 
 [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 [2] EDNRA, EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 9  Prostate cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] AR   D00462   Oxandrolone   [2] 211, 285 
 10  Purine metabolism 
 1 gene, 1 drug (DrugBank), 16 diseases shown 		  [1] PDE5A   D02229   Sildenafil   [16] 6, 46, 50, 51, 85, 86, 96, 113, 210, 211, 212, 225, 226, 278, 294, 299 
 D08514 
 11  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] EDNRB   D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 12  Renin secretion 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 
 13  Vascular smooth muscle contraction 
 1 gene, 2 drugs (DrugBank), 10 diseases shown 		  [1] EDNRA   D07077   Ambrisentan   [6] 51, 84, 85, 86, 88, 211 
 D01227   Bosentan   [10] 13, 41, 47, 51, 84, 85, 86, 88, 210, 211 
 D07538 

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