Home    Back

 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

A    B    C    D    E    F    G    H     I     J    K    L    M    N    O    P    Q    R    S    T    U    V    W    X    Y    Z    other

116 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Acute myeloid leukemia 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 2  Adipocytokine signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 3  African trypanosomiasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 4  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 5  Alanine, aspartate and glutamate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 6  Aldosterone synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 7  Allograft rejection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 8  Alzheimer disease 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 9  Amoebiasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 10  Amphetamine addiction 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 11  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 12  Antifolate resistance 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 13  Antigen processing and presentation 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 14  Apoptosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 15  Asthma 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 16  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 17  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 18  beta-Alanine metabolism 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 19  Butanoate metabolism 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 20  C-type lectin receptor signaling pathway 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 21  Calcium signaling pathway 
 12 genes, 3 drugs (DrugBank), 54 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [4] CHRM1, CHRM2, CHRM3, CHRM5   D00481   Propantheline   [1] 26 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 22  cAMP signaling pathway 
 2 genes, 1 drug (DrugBank), 1 disease shown 		  [2] CHRM1, CHRM2   D00481   Propantheline   [1] 26 
 23  Cell adhesion molecules (CAMs) 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 24  Cellular senescence 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 25  cGMP-PKG signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 26  Chagas disease (American trypanosomiasis) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 27  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CCR4   D09761   Mogamulizumab   [1] 26 
 28  Cholinergic synapse 
 5 genes, 1 drug (DrugBank), 1 disease shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00481   Propantheline   [1] 26 
 29  Circadian entrainment 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 30  Cortisol synthesis and secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 31  Cushing syndrome 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 32  Cytokine-cytokine receptor interaction 
 5 genes, 5 drugs (DrugBank), 32 diseases shown 		  [1] CCR4   D09761   Mogamulizumab   [1] 26 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 33  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 34  Dopaminergic synapse 
 3 genes, 1 drug (DrugBank), 44 diseases shown 		  [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 35  Epstein-Barr virus infection 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 36  Estrogen signaling pathway 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 37  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 38  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 39  GABAergic synapse 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] ABAT, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 40  Gap junction 
 9 genes, 1 drug (DrugBank), 4 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 41  Gastric acid secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D00481   Propantheline   [1] 26 
 42  Glucagon signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 43  Glutamatergic synapse 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 44  GnRH secretion 
 3 genes, 1 drug (DrugBank), 14 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 45  Graft-versus-host disease 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 46  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank), 29 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 47  Hepatitis B 
 2 genes, 3 drugs (DrugBank), 13 diseases shown 		  [1] IFNAR1   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 48  Hepatitis C 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 49  Herpes simplex virus 1 infection 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 50  Human cytomegalovirus infection 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 51  Human immunodeficiency virus 1 infection 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 52  Human papillomavirus infection 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 53  Human T-cell leukemia virus 1 infection 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 54  Hypertrophic cardiomyopathy (HCM) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 55  IL-17 signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 56  Inflammatory bowel disease (IBD) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 57  Influenza A 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 58  Insulin resistance 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 59  Insulin secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D00481   Propantheline   [1] 26 
 60  JAK-STAT signaling pathway 
 3 genes, 3 drugs (DrugBank), 31 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 61  Kaposi sarcoma-associated herpesvirus infection 
 8 genes, 4 drugs (DrugBank), 47 diseases shown 		  [1] CCR4   D09761   Mogamulizumab   [1] 26 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 62  Legionellosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 63  Leishmaniasis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 64  Long-term potentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 65  Malaria 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 66  MAPK signaling pathway 
 9 genes, 3 drugs (DrugBank), 57 diseases shown 		  [3] CACNA1G, CACNA1H, CACNA1I   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 67  Measles 
 2 genes, 2 drugs (DrugBank), 8 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 68  Metabolic pathways 
 4 genes, 1 drug (DrugBank), 14 diseases shown 		  [4] ABAT, ALDH5A1, GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 69  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 70  Natural killer cell mediated cytotoxicity 
 8 genes, 4 drugs (DrugBank), 50 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 71  Necroptosis 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 72  Neuroactive ligand-receptor interaction 
 6 genes, 4 drugs (DrugBank), 55 diseases shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00481   Propantheline   [1] 26 
 [1] NR3C1   D00407   Methylprednisolone   [36] 2, 13, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 63, 64, 65, 66, 83, 84, 86, 96, 97, 145, 164, 220, 222, 224, 271, 283, 284, 285, 296 
 D00751 
 D00979 
 D05000 
 D05001 
 D05002 
 D00472   Prednisolone   [38] 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   [44] 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 73  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 74  NOD-like receptor signaling pathway 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 75  Non-alcoholic fatty liver disease (NAFLD) 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 76  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 77  Osteoclast differentiation 
 8 genes, 4 drugs (DrugBank), 50 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 78  Oxytocin signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 79  Pancreatic secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D00481   Propantheline   [1] 26 
 80  Pathogenic Escherichia coli infection 
 10 genes, 2 drugs (DrugBank), 10 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 81  Pathways in cancer 
 4 genes, 4 drugs (DrugBank), 31 diseases shown 		  [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 82  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 6 genes, 2 drugs (DrugBank), 47 diseases shown 		  [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 83  Pertussis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 84  Phagosome 
 9 genes, 1 drug (DrugBank), 4 diseases shown 		  [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8   D02197   Vincristine   [4] 26, 34, 61, 331 
 D08679 
 85  PI3K-Akt signaling pathway 
 5 genes, 4 drugs (DrugBank), 31 diseases shown 		  [2] CHRM1, CHRM2   D00481   Propantheline   [1] 26 
 [1] CSF3R   D03235   Filgrastim   [28] 2, 6, 13, 16, 25, 26, 28, 34, 35, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 85, 96, 113, 164, 283, 284, 285, 331 
 [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 86  Platinum drug resistance 
 2 genes, 2 drugs (DrugBank), 13 diseases shown 		  [2] TOP2A, TOP2B   D03899   Doxorubicin   [6] 26, 28, 34, 61, 63, 331 
 D00125   Etoposide   [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 87  Propanoate metabolism 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 88  Proteasome 
 1 gene, 1 drug (DrugBank), 13 diseases shown 		  [1] PSMB5   D03150   Bortezomib   [13] 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 89  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 90  Regulation of actin cytoskeleton 
 5 genes, 1 drug (DrugBank), 1 disease shown 		  [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5   D00481   Propantheline   [1] 26 
 91  Renin secretion 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 92  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 93  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 94  Salivary secretion 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D00481   Propantheline   [1] 26 
 95  Shigellosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 96  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 97  Systemic lupus erythematosus 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 98  T cell receptor signaling pathway 
 7 genes, 3 drugs (DrugBank), 50 diseases shown 		  [1] PDCD1   D10316   Nivolumab   [10] 13, 26, 41, 46, 49, 50, 51, 53, 96, 97 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 99  Taste transduction 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CHRM3   D00481   Propantheline   [1] 26 
 100  Taurine and hypotaurine metabolism 
 2 genes, 1 drug (DrugBank), 14 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 101  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 102  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 103  Th17 cell differentiation 
 6 genes, 2 drugs (DrugBank), 45 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 104  TNF signaling pathway 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 105  Toll-like receptor signaling pathway 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] IFNAR1, IFNAR2   D03305   Interferon alfa   [5] 25, 26, 28, 56, 96 
 D04554   Interferon beta-1a   [5] 13, 14, 26, 96, 97 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 106  Toxoplasmosis 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 107  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 2 diseases shown 		  [1] RARA   D01418   Tamibarotene   [2] 26, 96 
 108  Tuberculosis 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 109  Type I diabetes mellitus 
 3 genes, 2 drugs (DrugBank), 20 diseases shown 		  [2] GAD1, GAD2   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 110  Type II diabetes mellitus 
 2 genes, 2 drugs (DrugBank), 20 diseases shown 		  [1] CACNA1G   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 111  Valine, leucine and isoleucine degradation 
 1 gene, 1 drug (DrugBank), 14 diseases shown 		  [1] ABAT   D00399   Valproic Acid   [14] 2, 3, 5, 8, 26, 34, 65, 89, 90, 102, 222, 233, 256, 331 
 112  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 113  Viral carcinogenesis 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] CCR4   D09761   Mogamulizumab   [1] 26 
 114  Viral protein interaction with cytokine and cytokine receptor 
 2 genes, 2 drugs (DrugBank), 8 diseases shown 		  [1] CCR4   D09761   Mogamulizumab   [1] 26 
 [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 
 115  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 116  Yersinia infection 
 1 gene, 1 drug (DrugBank), 8 diseases shown 		  [1] TNF   D04687   Lenalidomide   [8] 16, 26, 28, 34, 49, 96, 284, 300 

Back to top