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 Target Gene/Pathway 

   e.g. "Sirolimus", "Adalimumab", "MAP2K"

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137 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY * 
 On map, Yellow: Drug target, Red: Disease-related 		  KEGG GENES * 
 [Number of genes] 		  KEGG DRUG *   DrugBank   Disease ID * 
 [Number of diseases] 
 1  Adipocytokine signaling pathway 
 4 genes, 2 drugs (DrugBank), 11 diseases shown 		  [3] CPT1A, CPT1B, CPT1C   D05442   Perhexiline   [2] 58, 272 
 D08340 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 2  Adrenergic signaling in cardiomyocytes 
 9 genes, 9 drugs (DrugBank), 27 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 3  African trypanosomiasis 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 4  AGE-RAGE signaling pathway in diabetic complications 
 6 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 5  Alcoholism 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 6  Aldosterone synthesis and secretion 
 5 genes, 6 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 7  Aldosterone-regulated sodium reabsorption 
 1 gene, 1 drug (DrugBank), 6 diseases shown 		  [1] NR3C2   D00443   Spironolactone   [6] 58, 67, 86, 113, 218, 225 
 8  Allograft rejection 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 9  Alzheimer disease 
 12 genes, 5 drugs (DrugBank), 51 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MME   D10225   Sacubitril   [1] 58 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 10  Amoebiasis 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 11  Amphetamine addiction 
 7 genes, 3 drugs (DrugBank), 47 diseases shown 		  [2] CACNA1C, CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 12  AMPK signaling pathway 
 5 genes, 3 drugs (DrugBank), 20 diseases shown 		  [1] ADRA1A   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [3] CPT1A, CPT1B, CPT1C   D05442   Perhexiline   [2] 58, 272 
 D08340 
 [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 13  Amyotrophic lateral sclerosis (ALS) 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 14  Antifolate resistance 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 15  Antigen processing and presentation 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 16  Apelin signaling pathway 
 1 gene, 4 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 17  Apoptosis 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 18  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 19  Asthma 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 20  Autoimmune thyroid disease 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 21  Axon guidance 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 22  B cell receptor signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 23  Bile secretion 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 24  C-type lectin receptor signaling pathway 
 9 genes, 2 drugs (DrugBank), 48 diseases shown 		  [4] IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 25  Calcium signaling pathway 
 16 genes, 12 drugs (DrugBank), 63 diseases shown 		  [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 26  cAMP signaling pathway 
 7 genes, 6 drugs (DrugBank), 15 diseases shown 		  [2] ADORA1, ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 27  Carbohydrate digestion and absorption 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 28  Cardiac muscle contraction 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 29  Cellular senescence 
 8 genes, 4 drugs (DrugBank), 51 diseases shown 		  [1] CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [2] IL1A, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 30  cGMP-PKG signaling pathway 
 16 genes, 11 drugs (DrugBank), 63 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 31  Chagas disease (American trypanosomiasis) 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 32  Chemokine signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] CCL2   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 33  Cholinergic synapse 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 34  Circadian entrainment 
 2 genes, 2 drugs (DrugBank), 4 diseases shown 		  [2] CACNA1C, CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 35  Cortisol synthesis and secretion 
 5 genes, 6 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 36  Cushing syndrome 
 5 genes, 6 drugs (DrugBank), 24 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 37  Cytokine-cytokine receptor interaction 
 6 genes, 1 drug (DrugBank), 10 diseases shown 		  [6] CCL2, IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 38  Cytosolic DNA-sensing pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 39  Dilated cardiomyopathy (DCM) 
 6 genes, 5 drugs (DrugBank), 20 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 40  Dopaminergic synapse 
 5 genes, 3 drugs (DrugBank), 47 diseases shown 		  [2] CACNA1C, CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [3] PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 41  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 42  Epstein-Barr virus infection 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 43  Fatty acid degradation 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CPT1A, CPT1B, CPT1C, CPT2   D05442   Perhexiline   [2] 58, 272 
 D08340 
 44  Fatty acid metabolism 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CPT1A, CPT1B, CPT1C, CPT2   D05442   Perhexiline   [2] 58, 272 
 D08340 
 45  Fc epsilon RI signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 46  Fluid shear stress and atherosclerosis 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 47  FoxO signaling pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 48  GABAergic synapse 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 49  Gap junction 
 1 gene, 2 drugs (DrugBank), 8 diseases shown 		  [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 50  Glucagon signaling pathway 
 8 genes, 2 drugs (DrugBank), 45 diseases shown 		  [3] CPT1A, CPT1B, CPT1C   D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 51  Glutamatergic synapse 
 7 genes, 3 drugs (DrugBank), 47 diseases shown 		  [2] CACNA1C, CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 52  GnRH secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 53  GnRH signaling pathway 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 54  Graft-versus-host disease 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 55  Growth hormone synthesis, secretion and action 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 56  Hematopoietic cell lineage 
 5 genes, 2 drugs (DrugBank), 10 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [1] MME   D10225   Sacubitril   [1] 58 
 57  Hepatitis B 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 58  Hepatitis C 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 59  Herpes simplex virus 1 infection 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 60  HIF-1 signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 61  Human cytomegalovirus infection 
 9 genes, 2 drugs (DrugBank), 48 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 62  Human immunodeficiency virus 1 infection 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 63  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 64  Human T-cell leukemia virus 1 infection 
 7 genes, 2 drugs (DrugBank), 48 diseases shown 		  [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 65  Hypertrophic cardiomyopathy (HCM) 
 6 genes, 3 drugs (DrugBank), 13 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 66  IL-17 signaling pathway 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 67  Inflammatory bowel disease (IBD) 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 68  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL1B   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 69  Influenza A 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 70  Insulin resistance 
 4 genes, 2 drugs (DrugBank), 11 diseases shown 		  [2] CPT1A, CPT1B   D05442   Perhexiline   [2] 58, 272 
 D08340 
 [2] IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 71  Insulin secretion 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 72  Intestinal immune network for IgA production 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 73  JAK-STAT signaling pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 74  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 75  Legionellosis 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 76  Leishmaniasis 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] IL10, IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 77  Long-term potentiation 
 6 genes, 3 drugs (DrugBank), 47 diseases shown 		  [1] CACNA1C   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 78  Malaria 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 79  MAPK signaling pathway 
 12 genes, 4 drugs (DrugBank), 51 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 80  Measles 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 81  Metabolic pathways 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 82  Morphine addiction 
 1 gene, 1 drug (DrugBank), 5 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 83  mTOR signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 84  Natural killer cell mediated cytotoxicity 
 6 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 85  Necroptosis 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 86  Neuroactive ligand-receptor interaction 
 9 genes, 9 drugs (DrugBank), 26 diseases shown 		  [4] ADORA1, ADORA2A, ADORA2B, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 87  NF-kappa B signaling pathway 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 88  NOD-like receptor signaling pathway 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 89  Non-alcoholic fatty liver disease (NAFLD) 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 90  Oocyte meiosis 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 91  Osteoclast differentiation 
 8 genes, 2 drugs (DrugBank), 48 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 92  Oxytocin signaling pathway 
 9 genes, 3 drugs (DrugBank), 47 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 93  Parkinson disease 
 1 gene, 2 drugs (DrugBank), 5 diseases shown 		  [1] ADORA2A   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 D05711   Regadenoson   [1] 58 
 94  Pathogenic Escherichia coli infection 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 95  Pathways in cancer 
 2 genes, 5 drugs (DrugBank), 26 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 96  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 97  Pertussis 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 98  Phospholipase D signaling pathway 
 1 gene, 4 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 99  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 100  PPAR signaling pathway 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CPT1A, CPT1B, CPT1C, CPT2   D05442   Perhexiline   [2] 58, 272 
 D08340 
 101  Prion diseases 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 102  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank), 1 disease shown 		  [1] MME   D10225   Sacubitril   [1] 58 
 103  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 104  Rap1 signaling pathway 
 2 genes, 2 drugs (DrugBank), 5 diseases shown 		  [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 105  Regulation of lipolysis in adipocytes 
 2 genes, 3 drugs (DrugBank), 12 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 106  Renin secretion 
 12 genes, 10 drugs (DrugBank), 62 diseases shown 		  [1] ADORA1   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 107  Renin-angiotensin system 
 2 genes, 5 drugs (DrugBank), 21 diseases shown 		  [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [1] MME   D10225   Sacubitril   [1] 58 
 108  Retrograde endocannabinoid signaling 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 109  Rheumatoid arthritis 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] CCL2, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 110  RIG-I-like receptor signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 111  Salivary secretion 
 4 genes, 3 drugs (DrugBank), 9 diseases shown 		  [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] ADRB1   D00632   Dobutamine   [3] 57, 58, 215 
 D03879 
 D03880 
 D03881 
 D00601   Metoprolol   [7] 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 112  Salmonella infection 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 113  Serotonergic synapse 
 4 genes, 2 drugs (DrugBank), 4 diseases shown 		  [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 114  Shigellosis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 115  Sphingolipid signaling pathway 
 3 genes, 2 drugs (DrugBank), 13 diseases shown 		  [2] ADORA1, ADORA3   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 116  Staphylococcus aureus infection 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL10   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 117  Systemic lupus erythematosus 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 118  T cell receptor signaling pathway 
 7 genes, 2 drugs (DrugBank), 48 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 119  Taste transduction 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1C   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 120  Terpenoid backbone biosynthesis 
 1 gene, 1 drug (DrugBank), 17 diseases shown 		  [1] HMGCR   D00887   Atorvastatin   [17] 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 160, 222, 225, 265, 271, 299 
 D07474 
 121  TGF-beta signaling pathway 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 122  Th1 and Th2 cell differentiation 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 123  Th17 cell differentiation 
 7 genes, 2 drugs (DrugBank), 48 diseases shown 		  [2] IL1B, IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 124  Thermogenesis 
 4 genes, 1 drug (DrugBank), 2 diseases shown 		  [4] CPT1A, CPT1B, CPT1C, CPT2   D05442   Perhexiline   [2] 58, 272 
 D08340 
 125  Tight junction 
 1 gene, 2 drugs (DrugBank), 4 diseases shown 		  [1] CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 126  TNF signaling pathway 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 127  Toll-like receptor signaling pathway 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 128  Toxoplasmosis 
 2 genes, 1 drug (DrugBank), 10 diseases shown 		  [2] IL10, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 129  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank), 10 diseases shown 		  [1] IL6   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 130  Tuberculosis 
 10 genes, 2 drugs (DrugBank), 48 diseases shown 		  [5] IL10, IL1A, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 131  Type I diabetes mellitus 
 3 genes, 1 drug (DrugBank), 10 diseases shown 		  [3] IL1A, IL1B, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 132  Type II diabetes mellitus 
 3 genes, 3 drugs (DrugBank), 13 diseases shown 		  [2] CACNA1C, CACNA1D   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 [1] TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 133  Vascular smooth muscle contraction 
 10 genes, 9 drugs (DrugBank), 27 diseases shown 		  [1] ADORA2A   D05711   Regadenoson   [1] 58 
 [2] ADORA2A, ADORA2B   D00045   Adenosine   [5] 13, 46, 53, 58, 65 
 [3] ADRA1A, ADRA1B, ADRA1D   D01307   Midodrine   [3] 6, 17, 58 
 D08220 
 [1] AGTR1   D00522   Candesartan   [2] 58, 67 
 D00522   Candesartan cilexetil   [2] 58, 67 
 D00626 
 D00357   Losartan   [18] 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 D00400   Valsartan   [6] 57, 58, 66, 75, 218, 222 
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00616   Diltiazem   [3] 58, 86, 130 
 D03830 
 D07845 
 D05442   Perhexiline   [2] 58, 272 
 D08340 
 134  VEGF signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 135  Viral protein interaction with cytokine and cytokine receptor 
 4 genes, 1 drug (DrugBank), 10 diseases shown 		  [4] CCL2, IL10, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 
 136  Wnt signaling pathway 
 5 genes, 1 drug (DrugBank), 44 diseases shown 		  [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   [44] 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 137  Yersinia infection 
 5 genes, 1 drug (DrugBank), 10 diseases shown 		  [5] CCL2, IL10, IL1B, IL6, TNF   D01583   Pirfenidone   [10] 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 

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