Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 Mexiletine hydrochloride 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬
2 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 Mexiletine 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬
3 Breast cancer 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
4 Breast cancer 💬
1件: PGR 💬 Ulipristal acetate 💬 Ulipristal 1件: 10 💬
5 cAMP signaling pathway 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
6 cGMP-PKG signaling pathway 💬
1件: OPRD1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
7 cGMP-PKG signaling pathway 💬
1件: OPRD1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
8 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
9 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Ulipristal acetate 💬 Ulipristal 1件: 10 💬
10 Dopaminergic synapse 💬
1件: SCN1A 💬 Mexiletine hydrochloride 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬
11 Dopaminergic synapse 💬
1件: SCN1A 💬 Mexiletine 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬
12 Estrogen signaling pathway 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
13 Estrogen signaling pathway 💬
1件: OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
14 Estrogen signaling pathway 💬
1件: OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
15 Estrogen signaling pathway 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
16 Estrogen signaling pathway 💬
1件: PGR 💬 Ulipristal acetate 💬 Ulipristal 1件: 10 💬
17 Folate biosynthesis 💬
1件: AKR1B 💬 Epalrestat 💬 Epalrestat 1件: 10 💬
18 Fructose and mannose metabolism 💬
1件: AKR1B 💬 Epalrestat 💬 Epalrestat 1件: 10 💬
19 GABAergic synapse 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
20 Galactose metabolism 💬
1件: AKR1B 💬 Epalrestat 💬 Epalrestat 1件: 10 💬
21 Glycerolipid metabolism 💬
1件: AKR1B 💬 Epalrestat 💬 Epalrestat 1件: 10 💬
22 GnRH secretion 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
23 Hormone signaling 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
24 Hormone signaling 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
25 Morphine addiction 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
26 Morphine addiction 💬
1件: OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
27 Morphine addiction 💬
1件: OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
28 Neuroactive ligand signaling 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
29 Neuroactive ligand signaling 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
30 Neuroactive ligand signaling 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
31 Neuroactive ligand-receptor interaction 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
32 Neuroactive ligand-receptor interaction 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
33 Neuroactive ligand-receptor interaction 💬
3件: OPRD1, OPRK1, OPRM1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
34 Oocyte meiosis 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
35 Oocyte meiosis 💬
1件: PGR 💬 Ulipristal acetate 💬 Ulipristal 1件: 10 💬
36 Pentose and glucuronate interconversions 💬
1件: AKR1B 💬 Epalrestat 💬 Epalrestat 1件: 10 💬
37 Progesterone-mediated oocyte maturation 💬
1件: PGR 💬 Ulipristal 💬 Ulipristal 1件: 10 💬
38 Progesterone-mediated oocyte maturation 💬
1件: PGR 💬 Ulipristal acetate 💬 Ulipristal 1件: 10 💬
39 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 Naltrexone hydrochloride 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
40 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 Naltrexone 💬 Naltrexone 12件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
41 Taste transduction 💬
2件: GABBR, GABBR 💬 Baclofen 💬 Baclofen 8件:  2 , 10, 13, 18, 65, 70, 149, 206 💬
42 Taste transduction 💬
3件: SCN2A, SCN3A, SCN9A 💬 Mexiletine hydrochloride 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬
43 Taste transduction 💬
3件: SCN2A, SCN3A, SCN9A 💬 Mexiletine 💬 Mexiletine 5件:  1 ,  2 , 10, 113, 114 💬