Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Alcoholism 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
2 Alcoholism 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
3 Alzheimer disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
4 Alzheimer disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
5 Amphetamine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
6 Amphetamine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
7 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
8 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
9 Calcium signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
10 Calcium signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
11 cAMP signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
12 cAMP signaling pathway 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
13 cGMP-PKG signaling pathway 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
14 cGMP-PKG signaling pathway 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
15 Circadian entrainment 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
16 Circadian entrainment 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
17 Cocaine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
18 Cocaine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
19 Cortisol synthesis and secretion 💬
1件: KCNA4 💬 Dalfampridine 💬 Dalfampridine 4件:  3 ,  4 , 13, 14 💬
20 Cushing syndrome 💬
1件: KCNA4 💬 Dalfampridine 💬 Dalfampridine 4件:  3 ,  4 , 13, 14 💬
21 Dopaminergic synapse 💬
2件: GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
22 Dopaminergic synapse 💬
2件: GRIN2A, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
23 ECM-receptor interaction 💬
1件: SV2 💬 Levetiracetam 💬 Levetiracetam 7件:  2 ,  4 ,  6 , 13, 34, 149, 307 💬
24 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
25 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
26 Hormone signaling 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
27 Hormone signaling 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
28 Huntington disease 💬
2件: GRIN1, GRIN2B 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
29 Huntington disease 💬
2件: GRIN1, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
30 Long-term potentiation 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
31 Long-term potentiation 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
32 Neuroactive ligand signaling 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
33 Neuroactive ligand signaling 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
34 Neuroactive ligand signaling 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
35 Neuroactive ligand signaling 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
36 Neuroactive ligand-receptor interaction 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
37 Neuroactive ligand-receptor interaction 💬
3件: ADRA2A, ADRA2B, ADRA2C 💬 Dexmedetomidine hydrochloride 💬 Dexmedetomidine 15件:  2 ,  4 ,  6 , 21, 22, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬
38 Neuroactive ligand-receptor interaction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
39 Neuroactive ligand-receptor interaction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
40 Nicotine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
41 Nicotine addiction 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
42 Pathways of neurodegeneration - multiple diseases 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
43 Pathways of neurodegeneration - multiple diseases 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
44 Prion disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
45 Prion disease 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
46 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
47 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
48 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
49 Ras signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
50 Serotonergic synapse 💬
1件: KCND2 💬 Dalfampridine 💬 Dalfampridine 4件:  3 ,  4 , 13, 14 💬
51 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
52 Spinocerebellar ataxia 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
53 Spinocerebellar ataxia 💬
2件: KCNC3, KCND3 💬 Dalfampridine 💬 Dalfampridine 4件:  3 ,  4 , 13, 14 💬
54 Systemic lupus erythematosus 💬
2件: GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
55 Systemic lupus erythematosus 💬
2件: GRIN2A, GRIN2B 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬