Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adherens junction 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
2 Adherens junction 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
3 Alcoholism 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
4 Alcoholism 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
5 Alcoholism 💬
2件: DRD1, DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
6 Alcoholism 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
7 Alzheimer disease 💬
1件: MAPT 💬 Flortaucipir F 18 💬 Flortaucipir 3件:  5 ,  7 , 127 💬
8 Amphetamine addiction 💬
1件: DRD1 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
9 Amphetamine addiction 💬
1件: DRD1 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
10 Amphetamine addiction 💬
1件: DRD1 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
11 Amphetamine addiction 💬
1件: DRD1 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
12 Axon guidance 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
13 Axon guidance 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
14 Calcium signaling pathway 💬
1件: DRD1 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
15 Calcium signaling pathway 💬
1件: DRD1 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
16 Calcium signaling pathway 💬
2件: DRD1, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
17 Calcium signaling pathway 💬
2件: DRD1, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
18 cAMP signaling pathway 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
19 cAMP signaling pathway 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
20 cAMP signaling pathway 💬
3件: DRD1, DRD2, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
21 cAMP signaling pathway 💬
3件: DRD1, DRD2, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
22 cAMP signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
23 cAMP signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
24 cGMP-PKG signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
25 cGMP-PKG signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
26 Chemokine signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
27 Chemokine signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
28 Cocaine addiction 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
29 Cocaine addiction 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
30 Cocaine addiction 💬
2件: DRD1, DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
31 Cocaine addiction 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
32 Dopaminergic synapse 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
33 Dopaminergic synapse 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
34 Dopaminergic synapse 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
35 Dopaminergic synapse 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
36 Focal adhesion 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
37 Focal adhesion 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
38 Gap junction 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
39 Gap junction 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
40 Gap junction 💬
2件: DRD1, DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
41 Gap junction 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
42 Hormone signaling 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
43 Hormone signaling 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
44 Hormone signaling 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
45 Hormone signaling 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
46 Human cytomegalovirus infection 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
47 Human cytomegalovirus infection 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
48 Insulin secretion 💬
1件: SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A 14件:  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
49 Insulin secretion 💬
1件: SNAP25 💬 Prabotulinumtoxin A 💬 Botulinum toxin type A 14件:  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
50 Leukocyte transendothelial migration 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
51 Leukocyte transendothelial migration 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
52 Lipid and atherosclerosis 💬
1件: ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
53 Lipid and atherosclerosis 💬
1件: ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
54 MAPK signaling pathway 💬
1件: MAPT 💬 Flortaucipir F 18 💬 Flortaucipir 3件:  5 ,  7 , 127 💬
55 MicroRNAs in cancer 💬
1件: ROCK1 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
56 MicroRNAs in cancer 💬
1件: ROCK1 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
57 Morphine addiction 💬
1件: DRD1 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
58 Morphine addiction 💬
1件: DRD1 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
59 Morphine addiction 💬
1件: DRD1 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
60 Morphine addiction 💬
1件: DRD1 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
61 Neuroactive ligand signaling 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
62 Neuroactive ligand signaling 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
63 Neuroactive ligand signaling 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
64 Neuroactive ligand signaling 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
65 Neuroactive ligand-receptor interaction 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
66 Neuroactive ligand-receptor interaction 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
67 Neuroactive ligand-receptor interaction 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
68 Neuroactive ligand-receptor interaction 💬
5件: DRD1, DRD2, DRD3, DRD4, DRD5 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
69 Oxytocin signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
70 Oxytocin signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
71 Parkinson disease 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
72 Parkinson disease 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
73 Parkinson disease 💬
2件: DRD1, DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
74 Parkinson disease 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
75 Parkinson disease 💬
1件: MAPT 💬 Flortaucipir F 18 💬 Flortaucipir 3件:  5 ,  7 , 127 💬
76 Pathogenic Escherichia coli infection 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
77 Pathogenic Escherichia coli infection 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
78 Pathways in cancer 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
79 Pathways in cancer 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
80 Pathways of neurodegeneration - multiple diseases 💬
1件: MAPT 💬 Flortaucipir F 18 💬 Flortaucipir 3件:  5 ,  7 , 127 💬
81 Platelet activation 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
82 Platelet activation 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
83 Proteoglycans in cancer 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
84 Proteoglycans in cancer 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
85 Rap1 signaling pathway 💬
1件: DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
86 Rap1 signaling pathway 💬
1件: DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
87 Rap1 signaling pathway 💬
1件: DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
88 Rap1 signaling pathway 💬
1件: DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
89 Regulation of actin cytoskeleton 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
90 Regulation of actin cytoskeleton 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
91 Salmonella infection 💬
1件: ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
92 Salmonella infection 💬
1件: ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
93 Shigellosis 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
94 Shigellosis 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
95 Sphingolipid signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
96 Sphingolipid signaling pathway 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
97 Synaptic vesicle cycle 💬
1件: SNAP25 💬 Botulinum toxin type A 💬 Botulinum toxin type A 14件:  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
98 Synaptic vesicle cycle 💬
1件: SNAP25 💬 Prabotulinumtoxin A 💬 Botulinum toxin type A 14件:  2 ,  5 ,  6 ,  7 , 13, 15, 17, 47, 51, 70, 113, 149, 171, 226 💬
99 TGF-beta signaling pathway 💬
1件: ROCK1 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
100 TGF-beta signaling pathway 💬
1件: ROCK1 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
101 Tight junction 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
102 Tight junction 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
103 Vascular smooth muscle contraction 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
104 Vascular smooth muscle contraction 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
105 Wnt signaling pathway 💬
1件: ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
106 Wnt signaling pathway 💬
1件: ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
107 Yersinia infection 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
108 Yersinia infection 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬