Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Breast cancer 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
2 Breast cancer 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
3 Breast cancer 💬
1件: PGR 💬 Megestrol 💬 Megestrol 2件:  2 , 76 💬
4 Breast cancer 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
5 Breast cancer 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
6 Chemical carcinogenesis - receptor activation 💬
1件: AR 💬 Testosterone 💬 Testosterone 9件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
7 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
8 Chemical carcinogenesis - receptor activation 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
9 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Megestrol 💬 Megestrol 2件:  2 , 76 💬
10 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
11 Chemical carcinogenesis - receptor activation 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
12 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
13 Endocrine and other factor-regulated calcium reabsorption 💬
1件: ESR1 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
14 Endocrine and other factor-regulated calcium reabsorption 💬
1件: ESR1 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
15 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
16 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
17 Estrogen signaling pathway 💬
1件: PGR 💬 Megestrol 💬 Megestrol 2件:  2 , 76 💬
18 Estrogen signaling pathway 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
19 Estrogen signaling pathway 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
20 GnRH secretion 💬
1件: ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
21 GnRH secretion 💬
1件: ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
22 GnRH signaling pathway 💬
1件: GNRHR 💬 Gonadorelin hydrochloride 💬 Gonadorelin 1件: 76 💬
23 GnRH signaling pathway 💬
1件: GNRHR 💬 Gonadorelin acetate 💬 Gonadorelin 1件: 76 💬
24 GnRH signaling pathway 💬
1件: GNRHR 💬 Gonadorelin 💬 Gonadorelin 1件: 76 💬
25 GnRH signaling pathway 💬
1件: GNRHR 💬 Histrelin acetate 💬 Histrelin 1件: 76 💬
26 GnRH signaling pathway 💬
1件: GNRHR 💬 Histrelin 💬 Histrelin 1件: 76 💬
27 GnRH signaling pathway 💬
1件: GNRHR 💬 Leuprolide acetate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
28 GnRH signaling pathway 💬
1件: GNRHR 💬 Leuprorelin 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
29 GnRH signaling pathway 💬
1件: GNRHR 💬 Leuprolide mesylate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
30 GnRH signaling pathway 💬
1件: GNRHR 💬 Triptorelin 💬 Triptorelin 2件: 49, 76 💬
31 GnRH signaling pathway 💬
1件: GNRHR 💬 Triptorelin pamoate 💬 Triptorelin 2件: 49, 76 💬
32 GnRH signaling pathway 💬
1件: GNRHR 💬 Triptorelin acetate 💬 Triptorelin 2件: 49, 76 💬
33 Growth hormone synthesis, secretion and action 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
34 Hormone signaling 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
35 Hormone signaling 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
36 Hormone signaling 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
37 Hormone signaling 💬
1件: GNRHR 💬 Gonadorelin hydrochloride 💬 Gonadorelin 1件: 76 💬
38 Hormone signaling 💬
1件: GNRHR 💬 Gonadorelin acetate 💬 Gonadorelin 1件: 76 💬
39 Hormone signaling 💬
1件: GNRHR 💬 Gonadorelin 💬 Gonadorelin 1件: 76 💬
40 Hormone signaling 💬
1件: GNRHR 💬 Histrelin acetate 💬 Histrelin 1件: 76 💬
41 Hormone signaling 💬
1件: GNRHR 💬 Histrelin 💬 Histrelin 1件: 76 💬
42 Hormone signaling 💬
1件: GNRHR 💬 Leuprolide acetate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
43 Hormone signaling 💬
1件: GNRHR 💬 Leuprorelin 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
44 Hormone signaling 💬
1件: GNRHR 💬 Leuprolide mesylate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
45 Hormone signaling 💬
1件: GNRHR 💬 Triptorelin 💬 Triptorelin 2件: 49, 76 💬
46 Hormone signaling 💬
1件: GNRHR 💬 Triptorelin pamoate 💬 Triptorelin 2件: 49, 76 💬
47 Hormone signaling 💬
1件: GNRHR 💬 Triptorelin acetate 💬 Triptorelin 2件: 49, 76 💬
48 JAK-STAT signaling pathway 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
49 Neuroactive ligand-receptor interaction 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
50 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Gonadorelin hydrochloride 💬 Gonadorelin 1件: 76 💬
51 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Gonadorelin acetate 💬 Gonadorelin 1件: 76 💬
52 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Gonadorelin 💬 Gonadorelin 1件: 76 💬
53 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Histrelin acetate 💬 Histrelin 1件: 76 💬
54 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Histrelin 💬 Histrelin 1件: 76 💬
55 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Leuprolide acetate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
56 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Leuprorelin 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
57 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Leuprolide mesylate 💬 Leuprolide 5件:  1 ,  2 ,  3 , 67, 76 💬
58 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Triptorelin 💬 Triptorelin 2件: 49, 76 💬
59 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Triptorelin pamoate 💬 Triptorelin 2件: 49, 76 💬
60 Neuroactive ligand-receptor interaction 💬
1件: GNRHR 💬 Triptorelin acetate 💬 Triptorelin 2件: 49, 76 💬
61 Oocyte meiosis 💬
1件: AR 💬 Testosterone 💬 Testosterone 9件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
62 Oocyte meiosis 💬
1件: PGR 💬 Megestrol 💬 Megestrol 2件:  2 , 76 💬
63 Oocyte meiosis 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
64 Oocyte meiosis 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
65 Pathways in cancer 💬
1件: AR 💬 Testosterone 💬 Testosterone 9件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
66 Pathways in cancer 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
67 Pathways in cancer 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
68 PI3K-Akt signaling pathway 💬
1件: GHR 💬 Somatropin 💬 Somatotropin 28件:  2 ,  3 , 13, 19, 36, 46, 65, 74, 75, 76, 77, 78, 96, 97, 107, 113, 156, 187, 191, 193, 195, 238, 246, 265, 274, 276, 299, 337 💬
69 Progesterone-mediated oocyte maturation 💬
1件: PGR 💬 Megestrol 💬 Megestrol 2件:  2 , 76 💬
70 Progesterone-mediated oocyte maturation 💬
1件: PGR 💬 Megestrol acetate 💬 Megestrol acetate 1件: 76 💬
71 Progesterone-mediated oocyte maturation 💬
1件: PGR 💬 Progesterone 💬 Progesterone 2件: 76, 299 💬
72 Prolactin signaling pathway 💬
2件: ESR1, ESR2 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
73 Prolactin signaling pathway 💬
2件: ESR1, ESR2 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
74 Prostate cancer 💬
1件: AR 💬 Testosterone 💬 Testosterone 9件:  1 ,  2 ,  3 , 13, 60, 76, 78, 113, 265 💬
75 Proteoglycans in cancer 💬
1件: ESR1 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
76 Proteoglycans in cancer 💬
1件: ESR1 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬
77 Thyroid hormone signaling pathway 💬
1件: ESR1 💬 Estradiol 💬 Estradiol 3件: 13, 76, 299 💬
78 Thyroid hormone signaling pathway 💬
1件: ESR1 💬 Estradiol hemihydrate 💬 Estradiol 3件: 13, 76, 299 💬