Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Hepatitis B 💬
1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
2 Hepatitis B 💬
1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
3 Hepatitis B 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
4 Hepatitis B 💬
1件: BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib 1件: 34 💬
5 Hepatitis B 💬
2件: BRAF, RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
6 Hepatitis B 💬
2件: BRAF, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
7 Hepatitis B 💬
1件: CASP9 💬 Rimiducid 💬 Rimiducid 7件: 19, 49, 60, 65, 284, 285, 326 💬
8 Hepatitis B 💬
13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Sifalimumab 💬 Sifalimumab 1件: 49 💬
9 Hepatitis B 💬
13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Rontalizumab 💬 Rontalizumab 1件: 49 💬
10 Hepatitis B 💬
1件: IFNAR1 💬 Anifrolumab 💬 Anifrolumab 5件: 46, 49, 50, 51, 53 💬
11 Hepatitis B 💬
1件: IFNAR1 💬 Interferon beta 💬 Human interferon beta 5件: 13, 20, 50, 96, 97 💬
12 Hepatitis B 💬
1件: IFNAR1 💬 Interferon alfa 💬 Interferon alfa 2件: 25, 56 💬
13 Hepatitis B 💬
1件: IFNAR1 💬 Interferon alfa-2a 💬 Interferon alfa-2a 1件: 56 💬
14 Hepatitis B 💬
1件: IFNAR1 💬 Interferon alfa-2b 💬 Interferon alfa-2b 1件: 25 💬
15 Hepatitis B 💬
1件: IFNAR1 💬 Interferon beta-1a 💬 Interferon beta-1a 3件: 13, 96, 97 💬
16 Hepatitis B 💬
1件: IFNAR1 💬 Interferon beta-1b 💬 Interferon beta-1b 1件: 13 💬
17 Hepatitis B 💬
1件: IFNAR1 💬 Peginterferon alfa-2a 💬 Peginterferon alfa-2a 1件: 222 💬
18 Hepatitis B 💬
1件: IFNAR1 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a 1件: 13 💬
19 Hepatitis B 💬
1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
20 Hepatitis B 💬
1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
21 Hepatitis B 💬
1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
22 Hepatitis B 💬
1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
23 Hepatitis B 💬
2件: IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 Hepatitis B 💬
2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
25 Hepatitis B 💬
1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 2件: 39, 84 💬
26 Hepatitis B 💬
1件: JAK1 💬 Filgotinib 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
27 Hepatitis B 💬
1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬
28 Hepatitis B 💬
1件: JAK1 💬 Itacitinib adipate 💬 Itacitinib 4件: 46, 51, 97, 228 💬
29 Hepatitis B 💬
1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
30 Hepatitis B 💬
1件: JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
31 Hepatitis B 💬
1件: JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
32 Hepatitis B 💬
2件: JAK1, JAK2 💬 Baricitinib 💬 Baricitinib 21件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
33 Hepatitis B 💬
2件: JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
34 Hepatitis B 💬
2件: JAK1, JAK2 💬 Ruxolitinib phosphate 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
35 Hepatitis B 💬
3件: JAK1, JAK2, JAK3 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
36 Hepatitis B 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
37 Hepatitis B 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
38 Hepatitis B 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
39 Hepatitis B 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib citrate 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
40 Hepatitis B 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
41 Hepatitis B 💬
1件: JAK2 💬 Pacritinib 💬 Pacritinib 1件: 331 💬
42 Hepatitis B 💬
1件: JAK3 💬 Ritlecitinib tosylate 💬 Ritlecitinib 3件: 46, 96, 97 💬
43 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
44 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
45 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
46 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
47 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
48 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
49 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
50 Hepatitis B 💬
2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
51 Hepatitis B 💬
1件: MMP9 💬 Andecaliximab 💬 Andecaliximab 5件: 46, 96, 97, 272, 299 💬
52 Hepatitis B 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
53 Hepatitis B 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
54 Hepatitis B 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
55 Hepatitis B 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
56 Hepatitis B 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
57 Hepatitis B 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
58 Hepatitis B 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
59 Hepatitis B 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
60 Hepatitis B 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
61 Hepatitis B 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
62 Hepatitis B 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
63 Hepatitis B 💬
1件: SLC10A1 💬 Maralixibat 💬 Maralixibat 4件: 296, 297, 299, 338 💬
64 Hepatitis B 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
65 Hepatitis B 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
66 Hepatitis B 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
67 Hepatitis B 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
68 Hepatitis B 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
69 Hepatitis B 💬
3件: TGFB1, TGFB2, TGFB3 💬 Fresolimumab 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
70 Hepatitis B 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
71 Hepatitis B 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
72 Hepatitis B 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
73 Hepatitis B 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
74 Hepatitis B 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
75 Hepatitis B 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
76 Hepatitis B 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
77 Hepatitis B 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
78 Hepatitis B 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
79 Hepatitis B 💬
1件: TYK2 💬 Deucravacitinib 💬 Deucravacitinib 9件: 36, 37, 49, 53, 84, 96, 97, 160, 269 💬
80 Hepatitis B 💬
1件: TYK2 💬 Zasocitinib 💬 Zasocitinib 2件: 96, 97 💬