Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
2 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
3 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
4 T cell receptor signaling pathway 💬
 1件: CD4 💬 Zanolimumab 💬 Zanolimumab 1件: 46 💬
5 T cell receptor signaling pathway 💬
 1件: CD40LG 💬 Toralizumab 💬 Toralizumab 1件: 63 💬
6 T cell receptor signaling pathway 💬
 1件: CDK4 💬 Abemaciclib 💬 Abemaciclib 1件: 34 💬
7 T cell receptor signaling pathway 💬
 1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
8 T cell receptor signaling pathway 💬
 1件: CTLA4 💬 Ipilimumab 💬 Ipilimumab 1件: 159 💬
9 T cell receptor signaling pathway 💬
 1件: CTLA4 💬 Tremelimumab 💬 Tremelimumab 1件: 96 💬
10 T cell receptor signaling pathway 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
11 T cell receptor signaling pathway 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
12 T cell receptor signaling pathway 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 3件: 49, 65, 107 💬
13 T cell receptor signaling pathway 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
14 T cell receptor signaling pathway 💬
 2件: IL10, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
15 T cell receptor signaling pathway 💬
 1件: IL4 💬 Binetrakin 💬 Binetrakin 1件: 46 💬
16 T cell receptor signaling pathway 💬
 1件: IL5 💬 Mepolizumab 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
17 T cell receptor signaling pathway 💬
 1件: IL5 💬 Reslizumab 💬 Reslizumab 2件: 44, 98 💬
18 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
19 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
20 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬
21 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
22 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬
23 T cell receptor signaling pathway 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
24 T cell receptor signaling pathway 💬
 4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
25 T cell receptor signaling pathway 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 5件: 46, 51, 53, 271, 300 💬
26 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Nivolumab 💬 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
27 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Pembrolizumab 💬 Pembrolizumab 2件: 25, 285 💬
28 T cell receptor signaling pathway 💬
 1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬
29 T cell receptor signaling pathway 💬
 3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
30 T cell receptor signaling pathway 💬
 1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
31 T cell receptor signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
32 T cell receptor signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
33 T cell receptor signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
34 T cell receptor signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Tacrolimus 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
35 T cell receptor signaling pathway 💬
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
36 T cell receptor signaling pathway 💬
 1件: PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
37 T cell receptor signaling pathway 💬
 1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
38 T cell receptor signaling pathway 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
39 T cell receptor signaling pathway 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 17件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
40 T cell receptor signaling pathway 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
41 T cell receptor signaling pathway 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
42 T cell receptor signaling pathway 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
43 T cell receptor signaling pathway 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
44 T cell receptor signaling pathway 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
45 T cell receptor signaling pathway 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
46 T cell receptor signaling pathway 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
47 T cell receptor signaling pathway 💬
 1件: TNF 💬 Pomalidomide 💬 Pomalidomide 5件: 28, 51, 85, 227, 331 💬
48 T cell receptor signaling pathway 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬