Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Amyotrophic lateral sclerosis 💬
1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
2 Amyotrophic lateral sclerosis 💬
1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
3 Amyotrophic lateral sclerosis 💬
1件: CASP9 💬 Rimiducid 💬 Rimiducid 7件: 19, 49, 60, 65, 284, 285, 326 💬
4 Amyotrophic lateral sclerosis 💬
1件: ERBB4 💬 Afatinib 💬 Afatinib 1件: 285 💬
5 Amyotrophic lateral sclerosis 💬
1件: ERBB4 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
6 Amyotrophic lateral sclerosis 💬
1件: ERBB4 💬 Neratinib 💬 Neratinib 1件: 34 💬
7 Amyotrophic lateral sclerosis 💬
1件: ERBB4 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
8 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 Perampanel 💬 Perampanel 3件:  2 ,  6 , 144 💬
9 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 Perampanel hydrate 💬 Perampanel 3件:  2 ,  6 , 144 💬
10 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 Talampanel 💬 Talampanel 2件:  2 ,  6  💬
11 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 Topiramate 💬 Topiramate 5件:  6 , 140, 144, 156, 193 💬
12 Amyotrophic lateral sclerosis 💬
7件: GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole 8件:  2 ,  3 ,  5 ,  8 , 13, 17, 203, 206 💬
13 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate calcium 💬 Acamprosate 2件:  6 , 206 💬
14 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate 💬 Acamprosate 2件:  6 , 206 💬
15 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine hydrochloride 💬 Amantadine 5件:  2 ,  6 ,  8 , 13, 127 💬
16 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine 💬 Amantadine 5件:  2 ,  6 ,  8 , 13, 127 💬
17 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
18 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
19 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine hydrochloride 💬 Ketamine 6件:  6 , 13, 70, 113, 156, 215 💬
20 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine 💬 Ketamine 6件:  6 , 13, 70, 113, 156, 215 💬
21 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine 💬 Latrepirdine 1件:  8  💬
22 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine dihydrochloride 💬 Latrepirdine 1件:  8  💬
23 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
24 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
25 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone hydrochloride 💬 Methadone 1件: 60 💬
26 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone 💬 Methadone 1件: 60 💬
27 Amyotrophic lateral sclerosis 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Tenocyclidine 💬 Tenocyclidine 1件: 36 💬
28 Amyotrophic lateral sclerosis 💬
6件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Dextromethorphan hydrobromide 💬 Dextromethorphan 10件:  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
29 Amyotrophic lateral sclerosis 💬
6件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 Dextromethorphan 💬 Dextromethorphan 10件:  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
30 Amyotrophic lateral sclerosis 💬
1件: HDAC6 💬 Givinostat 💬 Givinostat 2件: 107, 113 💬
31 Amyotrophic lateral sclerosis 💬
1件: HDAC6 💬 Vorinostat 💬 Vorinostat 2件: 75, 96 💬
32 Amyotrophic lateral sclerosis 💬
2件: HDAC6, PIK3C3 💬 Fimepinostat 💬 Fimepinostat 1件: 75 💬
33 Amyotrophic lateral sclerosis 💬
1件: MAP3K5 💬 Selonsertib 💬 Selonsertib 1件: 86 💬
34 Amyotrophic lateral sclerosis 💬
1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
35 Amyotrophic lateral sclerosis 💬
1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
36 Amyotrophic lateral sclerosis 💬
1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
37 Amyotrophic lateral sclerosis 💬
2件: NOS1, NOS2 💬 Tilarginine acetate 💬 Tilarginine 1件: 67 💬
38 Amyotrophic lateral sclerosis 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
39 Amyotrophic lateral sclerosis 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
40 Amyotrophic lateral sclerosis 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
41 Amyotrophic lateral sclerosis 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
42 Amyotrophic lateral sclerosis 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
43 Amyotrophic lateral sclerosis 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
44 Amyotrophic lateral sclerosis 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
45 Amyotrophic lateral sclerosis 💬
1件: PSMB5 💬 Bortezomib 💬 Bortezomib 18件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 172, 222, 228, 256, 283, 288, 331 💬
46 Amyotrophic lateral sclerosis 💬
1件: PSMB5 💬 Carfilzomib 💬 Carfilzomib 1件: 28 💬
47 Amyotrophic lateral sclerosis 💬
1件: PSMB5 💬 Ixazomib 💬 Ixazomib 4件: 13, 16, 28, 51 💬
48 Amyotrophic lateral sclerosis 💬
1件: PSMB5 💬 Ixazomib citrate 💬 Ixazomib 4件: 13, 16, 28, 51 💬
49 Amyotrophic lateral sclerosis 💬
1件: SIGMAR1 💬 Blarcamesine 💬 Blarcamesine 2件:  6 , 156 💬
50 Amyotrophic lateral sclerosis 💬
1件: SIGMAR1 💬 Blarcamesine hydrochloride 💬 Blarcamesine 2件:  6 , 156 💬
51 Amyotrophic lateral sclerosis 💬
1件: SIGMAR1 💬 Fenfluramine hydrochloride 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
52 Amyotrophic lateral sclerosis 💬
1件: SIGMAR1 💬 Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
53 Amyotrophic lateral sclerosis 💬
1件: SOD1 💬 Tofersen 💬 Tofersen 1件:  2  💬
54 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
55 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
56 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
57 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
58 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
59 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
60 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
61 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
62 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
63 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
64 Amyotrophic lateral sclerosis 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
65 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vinblastine sulfate 💬 Vinblastine 3件: 34, 63, 65 💬
66 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Belantamab mafodotin 💬 Belantamab mafodotin 1件: 28 💬
67 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vinblastine 💬 Vinblastine 3件: 34, 63, 65 💬
68 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vincristine sulfate 💬 Vincristine 3件: 26, 34, 331 💬
69 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Paclitaxel 💬 Paclitaxel 1件: 85 💬
70 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Brentuximab vedotin 💬 Brentuximab vedotin 2件: 49, 51 💬
71 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Colchicine 💬 Colchicine 9件:  2 , 42, 46, 50, 56, 93, 97, 210, 266 💬
72 Amyotrophic lateral sclerosis 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vincristine 💬 Vincristine 3件: 26, 34, 331 💬
73 Carbohydrate digestion and absorption 💬
2件: AMY, AMY 💬 Acarbose 💬 Acarbose 1件: 298 💬
74 Pancreatic secretion 💬
2件: AMY, AMY 💬 Acarbose 💬 Acarbose 1件: 298 💬
75 Salivary secretion 💬
2件: AMY, AMY 💬 Acarbose 💬 Acarbose 1件: 298 💬
76 Starch and sucrose metabolism 💬
2件: AMY, AMY 💬 Acarbose 💬 Acarbose 1件: 298 💬