Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 HIF-1 signaling pathway 💬
 1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
2 HIF-1 signaling pathway 💬
 1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
3 HIF-1 signaling pathway 💬
 1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
4 HIF-1 signaling pathway 💬
 1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
5 HIF-1 signaling pathway 💬
 1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
6 HIF-1 signaling pathway 💬
 1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
7 HIF-1 signaling pathway 💬
 1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
8 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Afatinib 💬 Afatinib 1件: 285 💬
9 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
10 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
11 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
12 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Neratinib 💬 Neratinib 1件: 34 💬
13 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
14 HIF-1 signaling pathway 💬
 2件: EGFR, ERBB2 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
15 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Catequentinib 💬 Anlotinib 1件: 85 💬
16 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Axitinib 💬 Axitinib 1件: 34 💬
17 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Cediranib 💬 Cediranib 1件: 34 💬
18 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Cediranib maleate 💬 Cediranib 1件: 34 💬
19 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Nintedanib esylate 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
20 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Nintedanib 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
21 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Pazopanib hydrochloride 💬 Pazopanib 1件: 227 💬
22 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
23 HIF-1 signaling pathway 💬
 1件: FLT1 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
24 HIF-1 signaling pathway 💬
 1件: HMOX1 💬 Stannsoporfin 💬 Stannsoporfin 1件: 254 💬
25 HIF-1 signaling pathway 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
26 HIF-1 signaling pathway 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
27 HIF-1 signaling pathway 💬
 2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
28 HIF-1 signaling pathway 💬
 1件: IGF1R 💬 Linsitinib 💬 Linsitinib 1件: 232 💬
29 HIF-1 signaling pathway 💬
 1件: IGF1R 💬 Mecasermin 💬 Mecasermin 4件: 96, 168, 265, 299 💬
30 HIF-1 signaling pathway 💬
 1件: IGF1R 💬 Mecasermin rinfabate 💬 Mecasermin 4件: 96, 168, 265, 299 💬
31 HIF-1 signaling pathway 💬
 1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
32 HIF-1 signaling pathway 💬
 1件: IL6 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
33 HIF-1 signaling pathway 💬
 1件: IL6 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
34 HIF-1 signaling pathway 💬
 1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
35 HIF-1 signaling pathway 💬
 1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
36 HIF-1 signaling pathway 💬
 1件: IL6R 💬 Sarilumab 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
37 HIF-1 signaling pathway 💬
 1件: IL6R 💬 Satralizumab 💬 Satralizumab 4件: 11, 13, 86, 113 💬
38 HIF-1 signaling pathway 💬
 1件: IL6R 💬 Tocilizumab 💬 Tocilizumab 24件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
39 HIF-1 signaling pathway 💬
 1件: INSR 💬 Insulin detemir 💬 Insulin detemir 1件: 299 💬
40 HIF-1 signaling pathway 💬
 1件: INSR 💬 Insulin glargine 💬 Insulin glargine 1件: 299 💬
41 HIF-1 signaling pathway 💬
 1件: INSR 💬 Insulin human 💬 Insulin human 1件: 156 💬
42 HIF-1 signaling pathway 💬
 1件: INSR 💬 Insulin lispro 💬 Insulin lispro 1件: 53 💬
43 HIF-1 signaling pathway 💬
 1件: LDH 💬 Nedosiran sodium 💬 Nedosiran 1件: 234 💬
44 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
45 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
46 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
47 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
48 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
49 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
50 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
51 HIF-1 signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
52 HIF-1 signaling pathway 💬
 1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
53 HIF-1 signaling pathway 💬
 1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
54 HIF-1 signaling pathway 💬
 1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
55 HIF-1 signaling pathway 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
56 HIF-1 signaling pathway 💬
 2件: NOS2, NOS3 💬 Tilarginine acetate 💬 Tilarginine 1件: 67 💬
57 HIF-1 signaling pathway 💬
 1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
58 HIF-1 signaling pathway 💬
 1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
59 HIF-1 signaling pathway 💬
 1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
60 HIF-1 signaling pathway 💬
 2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
61 HIF-1 signaling pathway 💬
 3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
62 HIF-1 signaling pathway 💬
 1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
63 HIF-1 signaling pathway 💬
 1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
64 HIF-1 signaling pathway 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
65 HIF-1 signaling pathway 💬
 1件: TFRC 💬 Pabinafusp alfa 💬 Pabinafusp alfa 1件: 19 💬
66 HIF-1 signaling pathway 💬
 1件: TFRC 💬 Tividenofusp alfa 💬 Tividenofusp alfa 1件: 19 💬
67 HIF-1 signaling pathway 💬
 1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
68 HIF-1 signaling pathway 💬
 1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 8件: 13, 34, 85, 87, 89, 227, 280, 331 💬
69 HIF-1 signaling pathway 💬
 1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬