Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Focal adhesion 💬
1件: BCL2 💬 Obatoclax mesylate 💬 Obatoclax 1件: 60 💬
2 Focal adhesion 💬
1件: BCL2 💬 Venetoclax 💬 Venetoclax 2件: 28, 85 💬
3 Focal adhesion 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
4 Focal adhesion 💬
1件: BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib 1件: 34 💬
5 Focal adhesion 💬
5件: BRAF, FLT4, KDR, PDGFRB, RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
6 Focal adhesion 💬
5件: BRAF, FLT4, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
7 Focal adhesion 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
8 Focal adhesion 💬
1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
9 Focal adhesion 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
10 Focal adhesion 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
11 Focal adhesion 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
12 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Afatinib 💬 Afatinib 1件: 285 💬
13 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
14 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
15 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
16 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Neratinib 💬 Neratinib 1件: 34 💬
17 Focal adhesion 💬
2件: EGFR, ERBB2 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
18 Focal adhesion 💬
4件: EGFR, ERBB2, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
19 Focal adhesion 💬
3件: FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib 1件: 34 💬
20 Focal adhesion 💬
3件: FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib 1件: 34 💬
21 Focal adhesion 💬
3件: FLT1, FLT4, KDR 💬 Cediranib maleate 💬 Cediranib 1件: 34 💬
22 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib 1件: 85 💬
23 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
24 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
25 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib 1件: 227 💬
26 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
27 Focal adhesion 💬
5件: FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
28 Focal adhesion 💬
3件: FYN, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
29 Focal adhesion 💬
3件: FYN, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
30 Focal adhesion 💬
1件: IGF1R 💬 Linsitinib 💬 Linsitinib 1件: 232 💬
31 Focal adhesion 💬
1件: IGF1R 💬 Mecasermin 💬 Mecasermin 4件: 96, 168, 265, 299 💬
32 Focal adhesion 💬
1件: IGF1R 💬 Mecasermin rinfabate 💬 Mecasermin 4件: 96, 168, 265, 299 💬
33 Focal adhesion 💬
1件: ITGA4 💬 Firategrast 💬 Firategrast 1件: 13 💬
34 Focal adhesion 💬
1件: ITGA4 💬 Natalizumab 💬 Natalizumab 5件: 13, 15, 25, 46, 96 💬
35 Focal adhesion 💬
3件: ITGA4, ITGB1, ITGB7 💬 Carotegrast methyl 💬 Carotegrast methyl 1件: 97 💬
36 Focal adhesion 💬
2件: ITGA4, ITGB7 💬 Abrilumab 💬 Abrilumab 2件: 96, 97 💬
37 Focal adhesion 💬
2件: ITGA4, ITGB7 💬 Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
38 Focal adhesion 💬
3件: ITGA5, ITGB1, ITGB6 💬 Bexotegrast 💬 Bexotegrast 1件: 94 💬
39 Focal adhesion 💬
1件: ITGB7 💬 Etrolizumab 💬 Etrolizumab 2件: 96, 97 💬
40 Focal adhesion 💬
2件: KDR, MET 💬 Cabozantinib 💬 Cabozantinib 1件: 34 💬
41 Focal adhesion 💬
2件: KDR, MET 💬 Cabozantinib s-malate 💬 Cabozantinib 1件: 34 💬
42 Focal adhesion 💬
1件: MAP2K1 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
43 Focal adhesion 💬
1件: MAP2K1 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
44 Focal adhesion 💬
1件: MAP2K1 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
45 Focal adhesion 💬
1件: MAP2K1 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
46 Focal adhesion 💬
1件: MAP2K1 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
47 Focal adhesion 💬
1件: MAP2K1 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
48 Focal adhesion 💬
1件: MAP2K1 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
49 Focal adhesion 💬
1件: MAP2K1 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
50 Focal adhesion 💬
1件: MYL2 💬 Aficamten 💬 Aficamten 1件: 58 💬
51 Focal adhesion 💬
1件: PDGFRA 💬 Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
52 Focal adhesion 💬
1件: PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
53 Focal adhesion 💬
2件: PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
54 Focal adhesion 💬
2件: PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib 1件: 86 💬
55 Focal adhesion 💬
3件: PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
56 Focal adhesion 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
57 Focal adhesion 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
58 Focal adhesion 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
59 Focal adhesion 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
60 Focal adhesion 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
61 Focal adhesion 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
62 Focal adhesion 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
63 Focal adhesion 💬
2件: ROCK1, ROCK2 💬 Fasudil hydrochloride 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
64 Focal adhesion 💬
2件: ROCK1, ROCK2 💬 Fasudil 💬 Fasudil 5件:  2 ,  5 ,  6 ,  7 , 51 💬
65 Focal adhesion 💬
1件: ROCK2 💬 Belumosudil 💬 Belumosudil 3件: 51, 85, 228 💬
66 Focal adhesion 💬
1件: ROCK2 💬 Belumosudil mesylate 💬 Belumosudil 3件: 51, 85, 228 💬
67 Focal adhesion 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
68 Focal adhesion 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
69 Focal adhesion 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
70 Focal adhesion 💬
1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 8件: 13, 34, 85, 87, 89, 227, 280, 331 💬
71 Focal adhesion 💬
1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
72 Focal adhesion 💬
1件: VWF 💬 Caplacizumab 💬 Caplacizumab 2件: 63, 64 💬