Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Gap junction 💬
1件: ADRB1 💬 Amiodarone hydrochloride 💬 Amiodarone 1件: 127 💬
2 Gap junction 💬
1件: ADRB1 💬 Amiodarone 💬 Amiodarone 1件: 127 💬
3 Gap junction 💬
1件: ADRB1 💬 Atenolol 💬 Atenolol 1件: 167 💬
4 Gap junction 💬
1件: ADRB1 💬 Bevantolol hydrochloride 💬 Bevantolol 1件:  8  💬
5 Gap junction 💬
1件: ADRB1 💬 Bisoprolol fumarate 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
6 Gap junction 💬
1件: ADRB1 💬 Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬
7 Gap junction 💬
1件: ADRB1 💬 Carvedilol 💬 Carvedilol 6件:  6 , 46, 57, 86, 113, 210 💬
8 Gap junction 💬
1件: ADRB1 💬 Carvedilol phosphate 💬 Carvedilol 6件:  6 , 46, 57, 86, 113, 210 💬
9 Gap junction 💬
1件: ADRB1 💬 Celiprolol hydrochloride 💬 Celiprolol 1件: 168 💬
10 Gap junction 💬
1件: ADRB1 💬 Celiprolol 💬 Celiprolol 1件: 168 💬
11 Gap junction 💬
1件: ADRB1 💬 Dipivefrin hydrochloride 💬 Dipivefrin 1件:  6  💬
12 Gap junction 💬
1件: ADRB1 💬 Dipivefrin 💬 Dipivefrin 1件:  6  💬
13 Gap junction 💬
1件: ADRB1 💬 Dobutamine hydrochloride 💬 Dobutamine 4件: 57, 58, 86, 215 💬
14 Gap junction 💬
1件: ADRB1 💬 Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬
15 Gap junction 💬
1件: ADRB1 💬 Dobutamine tartrate 💬 Dobutamine 4件: 57, 58, 86, 215 💬
16 Gap junction 💬
1件: ADRB1 💬 Droxidopa 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
17 Gap junction 💬
1件: ADRB1 💬 Ephedrine 💬 Ephedrine 1件: 11 💬
18 Gap junction 💬
1件: ADRB1 💬 Ephedrine hydrochloride 💬 Ephedrine 1件: 11 💬
19 Gap junction 💬
1件: ADRB1 💬 Ephedrine sulfate 💬 Ephedrine 1件: 11 💬
20 Gap junction 💬
1件: ADRB1 💬 Epinephrine 💬 Epinephrine 1件: 46 💬
21 Gap junction 💬
1件: ADRB1 💬 Epinephrine hydrochloride 💬 Epinephrine 1件: 46 💬
22 Gap junction 💬
1件: ADRB1 💬 Epinephrine bitartrate 💬 Epinephrine 1件: 46 💬
23 Gap junction 💬
1件: ADRB1 💬 Metoprolol tartrate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
24 Gap junction 💬
1件: ADRB1 💬 Metoprolol succinate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
25 Gap junction 💬
1件: ADRB1 💬 Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
26 Gap junction 💬
1件: ADRB1 💬 Metoprolol fumarate 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
27 Gap junction 💬
1件: ADRB1 💬 Nadolol 💬 Nadolol 1件:  6  💬
28 Gap junction 💬
1件: ADRB1 💬 Nebivolol 💬 Nebivolol 4件: 17, 85, 113, 167 💬
29 Gap junction 💬
1件: ADRB1 💬 Nebivolol hydrochloride 💬 Nebivolol 4件: 17, 85, 113, 167 💬
30 Gap junction 💬
1件: ADRB1 💬 Noradrenaline 💬 Norepinephrine 2件: 22, 296 💬
31 Gap junction 💬
1件: ADRB1 💬 Norepinephrine bitartrate 💬 Norepinephrine 2件: 22, 296 💬
32 Gap junction 💬
1件: ADRB1 💬 Norepinephrine hydrochoride 💬 Norepinephrine 2件: 22, 296 💬
33 Gap junction 💬
1件: ADRB1 💬 Propranolol hydrochloride 💬 Propranolol 7件:  6 , 158, 215, 216, 227, 278, 296 💬
34 Gap junction 💬
1件: ADRB1 💬 Propranolol 💬 Propranolol 7件:  6 , 158, 215, 216, 227, 278, 296 💬
35 Gap junction 💬
1件: ADRB1 💬 Pseudoephedrine hydrochloride 💬 Pseudoephedrine 1件: 17 💬
36 Gap junction 💬
1件: ADRB1 💬 Pseudoephedrine sulfate 💬 Pseudoephedrine 1件: 17 💬
37 Gap junction 💬
1件: ADRB1 💬 Pseudoephedrine 💬 Pseudoephedrine 1件: 17 💬
38 Gap junction 💬
1件: ADRB1 💬 Timolol 💬 Timolol 2件: 157, 227 💬
39 Gap junction 💬
1件: ADRB1 💬 Timolol maleate 💬 Timolol 2件: 157, 227 💬
40 Gap junction 💬
1件: ADRB1 💬 Timolol 💬 Timolol 2件: 157, 227 💬
41 Gap junction 💬
1件: DRD1 💬 Tavapadon 💬 Tavapadon 1件:  6  💬
42 Gap junction 💬
2件: DRD1, DRD2 💬 Apomorphine hydrochloride 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
43 Gap junction 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
44 Gap junction 💬
2件: DRD1, DRD2 💬 Dexpramipexole 💬 Dexpramipexole 1件:  2  💬
45 Gap junction 💬
2件: DRD1, DRD2 💬 Dopamine hydrochloride 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
46 Gap junction 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 77 💬
47 Gap junction 💬
2件: DRD1, DRD2 💬 Flupentixol 💬 Flupentixol 1件: 97 💬
48 Gap junction 💬
2件: DRD1, DRD2 💬 Flupentixol dihydrochloride 💬 Flupentixol 1件: 97 💬
49 Gap junction 💬
2件: DRD1, DRD2 💬 Flupentixol decanoate 💬 Flupentixol 1件: 97 💬
50 Gap junction 💬
2件: DRD1, DRD2 💬 Foslevodopa 💬 Foslevodopa 1件:  6  💬
51 Gap junction 💬
2件: DRD1, DRD2 💬 Levodopa 💬 Levodopa 6件:  6 , 17, 90, 140, 164, 201 💬
52 Gap junction 💬
2件: DRD1, DRD2 💬 Pergolide mesylate 💬 Pergolide 1件:  6  💬
53 Gap junction 💬
2件: DRD1, DRD2 💬 Pergolide 💬 Pergolide 1件:  6  💬
54 Gap junction 💬
1件: DRD2 💬 Aplindore fumarate 💬 Aplindore 1件:  6  💬
55 Gap junction 💬
1件: DRD2 💬 Bromocriptine mesylate 💬 Bromocriptine 2件:  6 , 74 💬
56 Gap junction 💬
1件: DRD2 💬 Bromocriptine 💬 Bromocriptine 2件:  6 , 74 💬
57 Gap junction 💬
1件: DRD2 💬 Buspirone hydrochloride 💬 Buspirone 3件:  6 , 51, 179 💬
58 Gap junction 💬
1件: DRD2 💬 Buspirone 💬 Buspirone 3件:  6 , 51, 179 💬
59 Gap junction 💬
1件: DRD2 💬 Cabergoline 💬 Cabergoline 4件:  6 , 74, 75, 77 💬
60 Gap junction 💬
1件: DRD2 💬 Domperidone 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
61 Gap junction 💬
1件: DRD2 💬 Domperidone maleate 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
62 Gap junction 💬
1件: DRD2 💬 Haloperidol 💬 Haloperidol 1件:  8  💬
63 Gap junction 💬
1件: DRD2 💬 Haloperidol decanoate 💬 Haloperidol 1件:  8  💬
64 Gap junction 💬
1件: DRD2 💬 Haloperidol lactate 💬 Haloperidol 1件:  8  💬
65 Gap junction 💬
1件: DRD2 💬 Lisuride 💬 Lisuride 2件:  6 , 86 💬
66 Gap junction 💬
1件: DRD2 💬 Melperone 💬 Melperone 1件:  6  💬
67 Gap junction 💬
1件: DRD2 💬 Melperone hydrochloride 💬 Melperone 1件:  6  💬
68 Gap junction 💬
1件: DRD2 💬 Metoclopramide 💬 Metoclopramide 1件: 51 💬
69 Gap junction 💬
1件: DRD2 💬 Metoclopramide hydrochloride 💬 Metoclopramide 1件: 51 💬
70 Gap junction 💬
1件: DRD2 💬 Metoclopramide hydrochloride 💬 Metoclopramide 1件: 51 💬
71 Gap junction 💬
1件: DRD2 💬 Pardoprunox hydrochloride 💬 Pardoprunox 1件:  6  💬
72 Gap junction 💬
1件: DRD2 💬 Pardoprunox 💬 Pardoprunox 1件:  6  💬
73 Gap junction 💬
1件: DRD2 💬 Pimozide 💬 Pimozide 1件:  2  💬
74 Gap junction 💬
1件: DRD2 💬 Piribedil 💬 Piribedil 1件:  6  💬
75 Gap junction 💬
1件: DRD2 💬 Pramipexole dihydrochloride 💬 Pramipexole 2件:  6 , 20 💬
76 Gap junction 💬
1件: DRD2 💬 Pramipexole 💬 Pramipexole 2件:  6 , 20 💬
77 Gap junction 💬
1件: DRD2 💬 Pridopidine 💬 Pridopidine 3件:  2 ,  6 ,  8  💬
78 Gap junction 💬
1件: DRD2 💬 Pridopidine hydrochloride 💬 Pridopidine 3件:  2 ,  6 ,  8  💬
79 Gap junction 💬
1件: DRD2 💬 Ropinirole hydrochloride 💬 Ropinirole 3件:  6 , 74, 309 💬
80 Gap junction 💬
1件: DRD2 💬 Ropinirole 💬 Ropinirole 3件:  6 , 74, 309 💬
81 Gap junction 💬
1件: DRD2 💬 Rotigotine 💬 Rotigotine 3件:  6 , 67, 127 💬
82 Gap junction 💬
1件: DRD2 💬 Sarizotan hydrochloride 💬 Sarizotan 2件:  6 , 156 💬
83 Gap junction 💬
1件: DRD2 💬 Terguride 💬 Terguride 2件: 51, 86 💬
84 Gap junction 💬
1件: DRD2 💬 Trifluoperazine hydrochloride 💬 Trifluoperazine 2件: 283, 284 💬
85 Gap junction 💬
1件: DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine 2件: 283, 284 💬
86 Gap junction 💬
1件: DRD2 💬 Trifluoperazine 💬 Trifluoperazine 2件: 283, 284 💬
87 Gap junction 💬
2件: DRD2, HTR2 💬 Aripiprazole 💬 Aripiprazole 2件:  6 , 206 💬
88 Gap junction 💬
2件: DRD2, HTR2 💬 Quetiapine fumarate 💬 Quetiapine 1件:  6  💬
89 Gap junction 💬
2件: DRD2, HTR2 💬 Quetiapine 💬 Quetiapine 1件:  6  💬
90 Gap junction 💬
2件: DRD2, HTR2 💬 Risperidone 💬 Risperidone 3件:  8 , 156, 187 💬
91 Gap junction 💬
4件: DRD2, HTR2, HTR2, HTR2 💬 Iloperidone 💬 Iloperidone 1件:  6  💬
92 Gap junction 💬
4件: DRD2, HTR2, HTR2, HTR2 💬 Olanzapine 💬 Olanzapine 2件:  2 ,  8  💬
93 Gap junction 💬
4件: DRD2, HTR2, HTR2, HTR2 💬 Olanzapine pamoate 💬 Olanzapine 2件:  2 ,  8  💬
94 Gap junction 💬
4件: DRD2, HTR2, HTR2, HTR2 💬 Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
95 Gap junction 💬
4件: DRD2, HTR2, HTR2, HTR2 💬 Chlorpromazine hydrochloride 💬 Chlorpromazine 1件: 254 💬
96 Gap junction 💬
1件: EGFR 💬 Afatinib 💬 Afatinib 1件: 285 💬
97 Gap junction 💬
1件: EGFR 💬 Afatinib dimaleate 💬 Afatinib 1件: 285 💬
98 Gap junction 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
99 Gap junction 💬
1件: EGFR 💬 Erlotinib hydrochloride 💬 Erlotinib 2件: 94, 160 💬
100 Gap junction 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 2件: 94, 160 💬
101 Gap junction 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
102 Gap junction 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
103 Gap junction 💬
1件: EGFR 💬 Lapatinib ditosylate 💬 Lapatinib 3件: 34, 74, 75 💬
104 Gap junction 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
105 Gap junction 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
106 Gap junction 💬
1件: EGFR 💬 Neratinib maleate 💬 Neratinib 1件: 34 💬
107 Gap junction 💬
1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
108 Gap junction 💬
3件: GUCY1A, GUCY1A, GUCY1B 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
109 Gap junction 💬
3件: GUCY1A, GUCY1A, GUCY1B 💬 Zagociguat 💬 Zagociguat 1件: 21 💬
110 Gap junction 💬
3件: GUCY1A, GUCY1A, GUCY1B 💬 Amyl nitrite 💬 Amyl Nitrite 1件: 58 💬
111 Gap junction 💬
3件: GUCY1A, GUCY1A, GUCY1B 💬 Avenciguat 💬 Avenciguat 1件: 51 💬
112 Gap junction 💬
3件: GUCY1A, GUCY1A, GUCY1B 💬 Vericiguat 💬 Vericiguat 1件: 86 💬
113 Gap junction 💬
1件: HTR2 💬 Cisapride 💬 Cisapride 1件: 13 💬
114 Gap junction 💬
1件: HTR2 💬 Cisapride 💬 Cisapride 1件: 13 💬
115 Gap junction 💬
1件: HTR2 💬 Nelotanserin 💬 Nelotanserin 1件:  6  💬
116 Gap junction 💬
1件: HTR2 💬 Psilocybin 💬 Psilocybin 4件:  2 ,  6 , 13, 206 💬
117 Gap junction 💬
1件: HTR2 💬 Agomelatine 💬 Agomelatine 1件:  6  💬
118 Gap junction 💬
1件: HTR2 💬 Lorcaserin hydrochloride 💬 Lorcaserin 1件: 140 💬
119 Gap junction 💬
1件: HTR2 💬 Lorcaserin hydrochloride hemihydrate 💬 Lorcaserin 1件: 140 💬
120 Gap junction 💬
2件: HTR2, HTR2 💬 Clozapine 💬 Clozapine 1件:  6  💬
121 Gap junction 💬
2件: HTR2, HTR2 💬 Fenfluramine hydrochloride 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
122 Gap junction 💬
2件: HTR2, HTR2 💬 Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
123 Gap junction 💬
2件: HTR2, HTR2 💬 Pimavanserin tartrate 💬 Pimavanserin 1件:  6  💬
124 Gap junction 💬
3件: HTR2, HTR2, HTR2 💬 Mirtazapine 💬 Mirtazapine 3件:  6 , 85, 97 💬
125 Gap junction 💬
3件: HTR2, HTR2, HTR2 💬 Trazodone hydrochloride 💬 Trazodone 1件:  2  💬
126 Gap junction 💬
3件: HTR2, HTR2, HTR2 💬 Trazodone 💬 Trazodone 1件:  2  💬
127 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
128 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
129 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
130 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
131 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
132 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
133 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
134 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
135 Gap junction 💬
1件: PDGFRA 💬 Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
136 Gap junction 💬
1件: PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
137 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Catequentinib 💬 Anlotinib 1件: 85 💬
138 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
139 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Nintedanib esylate 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
140 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 7件: 51, 84, 85, 89, 227, 228, 331 💬
141 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Pazopanib hydrochloride 💬 Pazopanib 1件: 227 💬
142 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Seralutinib 💬 Seralutinib 1件: 86 💬
143 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
144 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
145 Gap junction 💬
2件: PDGFRB, RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
146 Gap junction 💬
2件: PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
147 Gap junction 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
148 Gap junction 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
149 Gap junction 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
150 Gap junction 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
151 Gap junction 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
152 Gap junction 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
153 Gap junction 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
154 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vinblastine sulfate 💬 Vinblastine 3件: 34, 63, 65 💬
155 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Brentuximab vedotin 💬 Brentuximab vedotin 2件: 49, 51 💬
156 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vincristine sulfate 💬 Vincristine 3件: 26, 34, 331 💬
157 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Belantamab mafodotin 💬 Belantamab mafodotin 1件: 28 💬
158 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Paclitaxel 💬 Paclitaxel 1件: 85 💬
159 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Colchicine 💬 Colchicine 9件:  2 , 42, 46, 50, 56, 93, 97, 210, 266 💬
160 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vinblastine 💬 Vinblastine 3件: 34, 63, 65 💬
161 Gap junction 💬
9件: TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB, TUBB 💬 Vincristine 💬 Vincristine 3件: 26, 34, 331 💬