Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Neutrophil extracellular trap formation 💬
1件: C3 💬 Pegcetacoplan 💬 Pegcetacoplan 4件:  2 , 61, 62, 222 💬
2 Neutrophil extracellular trap formation 💬
1件: C5 💬 Avacincaptad pegol sodium 💬 Avacincaptad pegol 1件: 301 💬
3 Neutrophil extracellular trap formation 💬
1件: C5 💬 Crovalimab 💬 Crovalimab 2件: 62, 109 💬
4 Neutrophil extracellular trap formation 💬
1件: C5 💬 Eculizumab 💬 Eculizumab 8件: 11, 13, 14, 61, 62, 109, 221, 222 💬
5 Neutrophil extracellular trap formation 💬
1件: C5 💬 Gefurulimab 💬 Gefurulimab 1件: 11 💬
6 Neutrophil extracellular trap formation 💬
1件: C5 💬 Nomacopan 💬 Nomacopan 3件: 62, 109, 162 💬
7 Neutrophil extracellular trap formation 💬
1件: C5 💬 Pozelimab 💬 Pozelimab 3件: 11, 15, 62 💬
8 Neutrophil extracellular trap formation 💬
1件: C5 💬 Ravulizumab 💬 Ravulizumab 7件:  2 , 11, 13, 50, 62, 66, 109 💬
9 Neutrophil extracellular trap formation 💬
1件: C5 💬 Vilobelimab 💬 Vilobelimab 3件: 43, 44, 269 💬
10 Neutrophil extracellular trap formation 💬
1件: C5 💬 Zilucoplan sodium 💬 Zilucoplan 2件: 11, 62 💬
11 Neutrophil extracellular trap formation 💬
1件: C5 💬 Zilucoplan 💬 Zilucoplan 2件: 11, 62 💬
12 Neutrophil extracellular trap formation 💬
1件: C5AR1 💬 Avacopan 💬 Avacopan 4件: 43, 44, 66, 222 💬
13 Neutrophil extracellular trap formation 💬
1件: ELANE 💬 Depelestat 💬 Depelestat 1件: 299 💬
14 Neutrophil extracellular trap formation 💬
1件: ELANE 💬 Sivelestat 💬 Sivelestat 3件: 13, 85, 96 💬
15 Neutrophil extracellular trap formation 💬
1件: ELANE 💬 Ulinastatin 💬 Ulinastatin 2件: 70, 299 💬
16 Neutrophil extracellular trap formation 💬
11件: HDAC10, HDAC11, HDAC1_2, HDAC1_2, HDAC3, HDAC4_5, HDAC4_5, HDAC6, HDAC7, HDAC8, HDAC9 💬 Givinostat 💬 Givinostat 2件: 107, 113 💬
17 Neutrophil extracellular trap formation 💬
11件: HDAC10, HDAC11, HDAC1_2, HDAC1_2, HDAC3, HDAC4_5, HDAC4_5, HDAC6, HDAC7, HDAC8, HDAC9 💬 Vorinostat 💬 Vorinostat 2件: 75, 96 💬
18 Neutrophil extracellular trap formation 💬
10件: HDAC10, HDAC1_2, HDAC1_2, HDAC3, HDAC4_5, HDAC4_5, HDAC6, HDAC7, HDAC8, HDAC9 💬 Fimepinostat 💬 Fimepinostat 1件: 75 💬
19 Neutrophil extracellular trap formation 💬
1件: ITGAL 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
20 Neutrophil extracellular trap formation 💬
1件: ITGAL 💬 Efalizumab 💬 Efalizumab 9件: 11, 13, 37, 46, 53, 61, 95, 96, 221 💬
21 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
22 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
23 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
24 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
25 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
26 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
27 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
28 Neutrophil extracellular trap formation 💬
2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
29 Neutrophil extracellular trap formation 💬
1件: MPO 💬 Verdiperstat 💬 Verdiperstat 2件: 17, 127 💬
30 Neutrophil extracellular trap formation 💬
1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
31 Neutrophil extracellular trap formation 💬
1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
32 Neutrophil extracellular trap formation 💬
1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
33 Neutrophil extracellular trap formation 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
34 Neutrophil extracellular trap formation 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
35 Neutrophil extracellular trap formation 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
36 Neutrophil extracellular trap formation 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
37 Neutrophil extracellular trap formation 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
38 Neutrophil extracellular trap formation 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
39 Neutrophil extracellular trap formation 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
40 Neutrophil extracellular trap formation 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
41 Neutrophil extracellular trap formation 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
42 Neutrophil extracellular trap formation 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
43 Neutrophil extracellular trap formation 💬
1件: RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
44 Neutrophil extracellular trap formation 💬
1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
45 Neutrophil extracellular trap formation 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
46 Neutrophil extracellular trap formation 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
47 Neutrophil extracellular trap formation 💬
1件: SRC 💬 Bosutinib hydrate 💬 Bosutinib 2件:  2 , 67 💬
48 Neutrophil extracellular trap formation 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
49 Neutrophil extracellular trap formation 💬
1件: SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
50 Neutrophil extracellular trap formation 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
51 Neutrophil extracellular trap formation 💬
1件: SYK 💬 Fostamatinib 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
52 Neutrophil extracellular trap formation 💬
1件: SYK 💬 Fostamatinib disodium 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
53 Neutrophil extracellular trap formation 💬
1件: SYK 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
54 Neutrophil extracellular trap formation 💬
1件: TLR7 💬 Imiquimod 💬 Imiquimod 2件: 34, 51 💬
55 Neutrophil extracellular trap formation 💬
2件: TLR7, TLR8 💬 Enpatoran 💬 Enpatoran 1件: 49 💬
56 Neutrophil extracellular trap formation 💬
1件: VWF 💬 Caplacizumab 💬 Caplacizumab 2件: 63, 64 💬