Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Toll-like receptor signaling pathway 💬
 2件: CD80, CD86 💬 Abatacept 💬 Abatacept 27件:  2 , 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
2 Toll-like receptor signaling pathway 💬
 2件: CD80, CD86 💬 Belatacept 💬 Belatacept 1件: 46 💬
3 Toll-like receptor signaling pathway 💬
 13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Rontalizumab 💬 Rontalizumab 1件: 49 💬
4 Toll-like receptor signaling pathway 💬
 13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Sifalimumab 💬 Sifalimumab 1件: 49 💬
5 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab 5件: 46, 49, 50, 51, 53 💬
6 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta 💬 Human interferon beta 5件: 13, 20, 50, 96, 97 💬
7 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa 2件: 25, 56 💬
8 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a 1件: 56 💬
9 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b 1件: 25 💬
10 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a 3件: 13, 96, 97 💬
11 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b 1件: 13 💬
12 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Peginterferon alfa-2a 💬 Peginterferon alfa-2a 1件: 222 💬
13 Toll-like receptor signaling pathway 💬
 2件: IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a 1件: 13 💬
14 Toll-like receptor signaling pathway 💬
 1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
15 Toll-like receptor signaling pathway 💬
 2件: IL12A, IL12B 💬 Ustekinumab 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
16 Toll-like receptor signaling pathway 💬
 1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
17 Toll-like receptor signaling pathway 💬
 1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
18 Toll-like receptor signaling pathway 💬
 1件: IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
19 Toll-like receptor signaling pathway 💬
 1件: IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
20 Toll-like receptor signaling pathway 💬
 3件: IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
21 Toll-like receptor signaling pathway 💬
 1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
22 Toll-like receptor signaling pathway 💬
 1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
23 Toll-like receptor signaling pathway 💬
 1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
24 Toll-like receptor signaling pathway 💬
 2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
25 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 2件: 39, 84 💬
26 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Baricitinib 💬 Baricitinib 21件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
27 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Filgotinib 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
28 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
29 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬
30 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Itacitinib adipate 💬 Itacitinib 4件: 46, 51, 97, 228 💬
31 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
32 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Ruxolitinib 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
33 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Ruxolitinib phosphate 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
34 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
35 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
36 Toll-like receptor signaling pathway 💬
 1件: JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
37 Toll-like receptor signaling pathway 💬
 2件: JAK1, TYK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
38 Toll-like receptor signaling pathway 💬
 2件: JAK1, TYK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
39 Toll-like receptor signaling pathway 💬
 2件: JAK1, TYK2 💬 Tofacitinib citrate 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
40 Toll-like receptor signaling pathway 💬
 2件: JAK1, TYK2 💬 Tofacitinib 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
41 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
42 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
43 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
44 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
45 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
46 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
47 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
48 Toll-like receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
49 Toll-like receptor signaling pathway 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
50 Toll-like receptor signaling pathway 💬
 4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
51 Toll-like receptor signaling pathway 💬
 4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
52 Toll-like receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
53 Toll-like receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
54 Toll-like receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
55 Toll-like receptor signaling pathway 💬
 2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
56 Toll-like receptor signaling pathway 💬
 3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
57 Toll-like receptor signaling pathway 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
58 Toll-like receptor signaling pathway 💬
 1件: RIPK1 💬 Eclitasertib 💬 SAR443122 1件: 97 💬
59 Toll-like receptor signaling pathway 💬
 1件: TLR7 💬 Imiquimod 💬 Imiquimod 2件: 34, 51 💬
60 Toll-like receptor signaling pathway 💬
 2件: TLR7, TLR8 💬 Enpatoran 💬 Enpatoran 1件: 49 💬
61 Toll-like receptor signaling pathway 💬
 1件: TLR9 💬 Cobitolimod 💬 Cobitolimod 1件: 97 💬
62 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
63 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
64 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
65 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
66 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
67 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
68 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
69 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
70 Toll-like receptor signaling pathway 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
71 Toll-like receptor signaling pathway 💬
 1件: TNFRSF5 💬 Bleselumab 💬 Bleselumab 1件: 222 💬
72 Toll-like receptor signaling pathway 💬
 1件: TNFRSF5 💬 Iscalimab 💬 Iscalimab 2件: 49, 53 💬
73 Toll-like receptor signaling pathway 💬
 1件: TNFRSF5 💬 Ravagalimab 💬 Ravagalimab 3件: 46, 53, 97 💬
74 Toll-like receptor signaling pathway 💬
 1件: TYK2 💬 Deucravacitinib 💬 Deucravacitinib 9件: 36, 37, 49, 53, 84, 96, 97, 160, 269 💬
75 Toll-like receptor signaling pathway 💬
 1件: TYK2 💬 Zasocitinib 💬 Zasocitinib 2件: 96, 97 💬