Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Hematopoietic cell lineage 💬
1件: ANPEP 💬 Ubenimex 💬 Ubenimex 1件: 86 💬
2 Hematopoietic cell lineage 💬
1件: CD19 💬 Inebilizumab 💬 Inebilizumab 6件: 11, 13, 46, 49, 51, 300 💬
3 Hematopoietic cell lineage 💬
1件: CD19 💬 Obecabtagene autoleucel 💬 Obecabtagene autoleucel 1件: 49 💬
4 Hematopoietic cell lineage 💬
1件: CD19 💬 Obexelimab 💬 Obexelimab 4件: 13, 49, 61, 300 💬
5 Hematopoietic cell lineage 💬
1件: CD19 💬 Tafasitamab 💬 Tafasitamab 1件: 51 💬
6 Hematopoietic cell lineage 💬
4件: CD19, CD3D, CD3E, CD3G 💬 Blinatumomab 💬 Blinatumomab 3件: 11, 46, 49 💬
7 Hematopoietic cell lineage 💬
1件: CD2 💬 Siplizumab 💬 Siplizumab 2件: 94, 95 💬
8 Hematopoietic cell lineage 💬
1件: CD22 💬 Epratuzumab 💬 Epratuzumab 1件: 49 💬
9 Hematopoietic cell lineage 💬
10件: CD2, CD3D, CD3E, CD3G, CD4, CD5, CD7, CD8A, CD8B, IL2RA 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
10 Hematopoietic cell lineage 💬
1件: CD34 💬 Omidubicel 💬 Omidubicel 1件: 60 💬
11 Hematopoietic cell lineage 💬
1件: CD38 💬 Ciltacabtagene autoleucel 💬 Ciltacabtagene autoleucel 1件: 28 💬
12 Hematopoietic cell lineage 💬
1件: CD38 💬 Daratumumab 💬 Daratumumab 10件: 13, 16, 28, 46, 48, 49, 60, 63, 288, 331 💬
13 Hematopoietic cell lineage 💬
1件: CD38 💬 Isatuximab 💬 Isatuximab 3件: 28, 61, 283 💬
14 Hematopoietic cell lineage 💬
1件: CD38 💬 Mezagitamab 💬 Mezagitamab 2件: 63, 66 💬
15 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 Muromonab-CD3 💬 Muromonab 3件: 60, 96, 97 💬
16 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
17 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
18 Hematopoietic cell lineage 💬
1件: CD3E 💬 Elranatamab 💬 Elranatamab 1件: 28 💬
19 Hematopoietic cell lineage 💬
1件: CD3E 💬 Talquetamab 💬 Talquetamab 1件: 28 💬
20 Hematopoietic cell lineage 💬
1件: CD3E 💬 Teclistamab 💬 Teclistamab 1件: 28 💬
21 Hematopoietic cell lineage 💬
2件: CD3E, MS4A1 💬 Imvotamab 💬 Imvotamab 2件: 46, 49 💬
22 Hematopoietic cell lineage 💬
2件: CD3E, MS4A1 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
23 Hematopoietic cell lineage 💬
1件: CD4 💬 Zanolimumab 💬 Zanolimumab 1件: 46 💬
24 Hematopoietic cell lineage 💬
1件: CSF1R 💬 Axatilimab 💬 Axatilimab 1件: 85 💬
25 Hematopoietic cell lineage 💬
3件: CSF1R, FLT3, KIT 💬 Sunitinib malate 💬 Sunitinib 2件: 28, 34 💬
26 Hematopoietic cell lineage 💬
3件: CSF1R, FLT3, KIT 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
27 Hematopoietic cell lineage 💬
1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
28 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 Mavrilimumab 💬 Mavrilimumab 2件: 41, 46 💬
29 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 Molgramostim 💬 Molgramostim 2件: 229, 299 💬
30 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 Regramostim 💬 Regramostim 1件: 229 💬
31 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 Sargramostim 💬 Sargramostim 7件:  6 , 28, 60, 62, 96, 229, 285 💬
32 Hematopoietic cell lineage 💬
1件: CSF3R 💬 Filgrastim 💬 Filgrastim 29件:  2 ,  6 , 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 47, 49, 51, 60, 62, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
33 Hematopoietic cell lineage 💬
1件: CSF3R 💬 Lenograstim 💬 Lenograstim 8件:  2 , 13, 16, 18, 19, 57, 65, 97 💬
34 Hematopoietic cell lineage 💬
1件: CSF3R 💬 Pegfilgrastim 💬 Pegfilgrastim 1件: 60 💬
35 Hematopoietic cell lineage 💬
1件: EPOR 💬 Epoetin beta 💬 Epoetin beta 2件: 13, 18 💬
36 Hematopoietic cell lineage 💬
1件: EPOR 💬 Epoetin alfa 💬 Erythropoietin 11件:  2 ,  6 , 13, 18, 22, 46, 47, 61, 70, 95, 96 💬
37 Hematopoietic cell lineage 💬
1件: EPOR 💬 Epoetin epsilon 💬 Erythropoietin 11件:  2 ,  6 , 13, 18, 22, 46, 47, 61, 70, 95, 96 💬
38 Hematopoietic cell lineage 💬
1件: EPOR 💬 Epoetin theta 💬 Erythropoietin 11件:  2 ,  6 , 13, 18, 22, 46, 47, 61, 70, 95, 96 💬
39 Hematopoietic cell lineage 💬
1件: EPOR 💬 Epoetin zeta 💬 Erythropoietin 11件:  2 ,  6 , 13, 18, 22, 46, 47, 61, 70, 95, 96 💬
40 Hematopoietic cell lineage 💬
1件: EPOR 💬 Peginesatide 💬 Peginesatide 1件: 283 💬
41 Hematopoietic cell lineage 💬
1件: EPOR 💬 Peginesatide acetate 💬 Peginesatide 1件: 283 💬
42 Hematopoietic cell lineage 💬
1件: FLT3 💬 Pacritinib 💬 Pacritinib 1件: 331 💬
43 Hematopoietic cell lineage 💬
2件: FLT3, KIT 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
44 Hematopoietic cell lineage 💬
2件: FLT3, KIT 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
45 Hematopoietic cell lineage 💬
1件: IL11RA 💬 Oprelvekin 💬 Oprelvekin 3件: 96, 97, 288 💬
46 Hematopoietic cell lineage 💬
1件: IL1A 💬 Bermekimab 💬 Bermekimab 1件: 51 💬
47 Hematopoietic cell lineage 💬
2件: IL1A, IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
48 Hematopoietic cell lineage 💬
2件: IL1A, IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
49 Hematopoietic cell lineage 💬
4件: IL1A, IL1B, IL6, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
50 Hematopoietic cell lineage 💬
1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
51 Hematopoietic cell lineage 💬
1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
52 Hematopoietic cell lineage 💬
2件: IL1R1, IL1R2 💬 Anakinra 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
53 Hematopoietic cell lineage 💬
1件: IL2RA 💬 Aldesleukin 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
54 Hematopoietic cell lineage 💬
1件: IL2RA 💬 Basiliximab 💬 Basiliximab 5件:  2 , 50, 97, 222, 228 💬
55 Hematopoietic cell lineage 💬
1件: IL2RA 💬 Daclizumab 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
56 Hematopoietic cell lineage 💬
1件: IL4R 💬 Dupilumab 💬 Dupilumab 5件: 51, 97, 98, 160, 162 💬
57 Hematopoietic cell lineage 💬
1件: IL5 💬 Depemokimab 💬 Depemokimab 2件: 44, 45 💬
58 Hematopoietic cell lineage 💬
1件: IL5 💬 Mepolizumab 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
59 Hematopoietic cell lineage 💬
1件: IL5 💬 Reslizumab 💬 Reslizumab 2件: 44, 98 💬
60 Hematopoietic cell lineage 💬
1件: IL5RA 💬 Benralizumab 💬 Benralizumab 5件: 44, 45, 98, 162, 299 💬
61 Hematopoietic cell lineage 💬
1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
62 Hematopoietic cell lineage 💬
1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
63 Hematopoietic cell lineage 💬
1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
64 Hematopoietic cell lineage 💬
2件: IL6, TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
65 Hematopoietic cell lineage 💬
1件: IL6R 💬 Sarilumab 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
66 Hematopoietic cell lineage 💬
1件: IL6R 💬 Satralizumab 💬 Satralizumab 4件: 11, 13, 86, 113 💬
67 Hematopoietic cell lineage 💬
1件: IL6R 💬 Tocilizumab 💬 Tocilizumab 24件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
68 Hematopoietic cell lineage 💬
1件: IL7R 💬 Lusvertikimab 💬 Lusvertikimab 1件: 97 💬
69 Hematopoietic cell lineage 💬
1件: ITGA4 💬 Abrilumab 💬 Abrilumab 2件: 96, 97 💬
70 Hematopoietic cell lineage 💬
1件: ITGA4 💬 Carotegrast methyl 💬 Carotegrast methyl 1件: 97 💬
71 Hematopoietic cell lineage 💬
1件: ITGA4 💬 Firategrast 💬 Firategrast 1件: 13 💬
72 Hematopoietic cell lineage 💬
1件: ITGA4 💬 Natalizumab 💬 Natalizumab 5件: 13, 15, 25, 46, 96 💬
73 Hematopoietic cell lineage 💬
1件: ITGA4 💬 Vedolizumab 💬 Vedolizumab 3件: 94, 96, 97 💬
74 Hematopoietic cell lineage 💬
1件: ITGA5 💬 Bexotegrast 💬 Bexotegrast 1件: 94 💬
75 Hematopoietic cell lineage 💬
1件: KIT 💬 Catequentinib 💬 Anlotinib 1件: 85 💬
76 Hematopoietic cell lineage 💬
1件: KIT 💬 Barzolvolimab 💬 Barzolvolimab 1件: 98 💬
77 Hematopoietic cell lineage 💬
1件: KIT 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
78 Hematopoietic cell lineage 💬
1件: KIT 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
79 Hematopoietic cell lineage 💬
1件: KIT 💬 Imatinib mesylate 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
80 Hematopoietic cell lineage 💬
1件: KIT 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
81 Hematopoietic cell lineage 💬
1件: KIT 💬 Masitinib 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
82 Hematopoietic cell lineage 💬
1件: KIT 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
83 Hematopoietic cell lineage 💬
1件: KIT 💬 Pazopanib hydrochloride 💬 Pazopanib 1件: 227 💬
84 Hematopoietic cell lineage 💬
14件: MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Glatiramer acetate 💬 Glatiramer 3件: 13, 96, 156 💬
85 Hematopoietic cell lineage 💬
1件: MME 💬 Sacubitril 💬 Sacubitril 3件: 58, 210, 222 💬
86 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Divozilimab 💬 Divozilimab 2件: 13, 51 💬
87 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Obinutuzumab 💬 Obinutuzumab 5件: 43, 44, 49, 63, 222 💬
88 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Ocrelizumab 💬 Ocrelizumab 4件: 11, 13, 46, 49 💬
89 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Ofatumumab 💬 Ofatumumab 4件: 11, 13, 35, 46 💬
90 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Rituximab 💬 Rituximab 52件: 11, 13, 14, 19, 26, 34, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 172, 220, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
91 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Ublituximab 💬 Ublituximab 1件: 13 💬
92 Hematopoietic cell lineage 💬
1件: MS4A1 💬 Veltuzumab 💬 Veltuzumab 2件: 46, 63 💬
93 Hematopoietic cell lineage 💬
1件: TFRC 💬 Pabinafusp alfa 💬 Pabinafusp alfa 1件: 19 💬
94 Hematopoietic cell lineage 💬
1件: TFRC 💬 Tividenofusp alfa 💬 Tividenofusp alfa 1件: 19 💬
95 Hematopoietic cell lineage 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
96 Hematopoietic cell lineage 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
97 Hematopoietic cell lineage 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
98 Hematopoietic cell lineage 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
99 Hematopoietic cell lineage 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
100 Hematopoietic cell lineage 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
101 Hematopoietic cell lineage 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
102 Hematopoietic cell lineage 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
103 Hematopoietic cell lineage 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬