Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Natural killer cell mediated cytotoxicity 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
2 Natural killer cell mediated cytotoxicity 💬
1件: BRAF 💬 Dabrafenib mesylate 💬 Dabrafenib 1件: 34 💬
3 Natural killer cell mediated cytotoxicity 💬
2件: BRAF, RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
4 Natural killer cell mediated cytotoxicity 💬
2件: BRAF, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
5 Natural killer cell mediated cytotoxicity 💬
1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
6 Natural killer cell mediated cytotoxicity 💬
2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
7 Natural killer cell mediated cytotoxicity 💬
2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
8 Natural killer cell mediated cytotoxicity 💬
1件: ICAM1 💬 Alicaforsen sodium 💬 Alicaforsen 2件: 96, 97 💬
9 Natural killer cell mediated cytotoxicity 💬
13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Rontalizumab 💬 Rontalizumab 1件: 49 💬
10 Natural killer cell mediated cytotoxicity 💬
13件: IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA, IFNA 💬 Sifalimumab 💬 Sifalimumab 1件: 49 💬
11 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Anifrolumab 💬 Anifrolumab 5件: 46, 49, 50, 51, 53 💬
12 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon beta 💬 Human interferon beta 5件: 13, 20, 50, 96, 97 💬
13 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon alfa 💬 Interferon alfa 2件: 25, 56 💬
14 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon alfa-2a 💬 Interferon alfa-2a 1件: 56 💬
15 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon alfa-2b 💬 Interferon alfa-2b 1件: 25 💬
16 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon beta-1a 💬 Interferon beta-1a 3件: 13, 96, 97 💬
17 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Interferon beta-1b 💬 Interferon beta-1b 1件: 13 💬
18 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Peginterferon alfa-2a 💬 Peginterferon alfa-2a 1件: 222 💬
19 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 Peginterferon beta-1a 💬 Peginterferon beta-1a 1件: 13 💬
20 Natural killer cell mediated cytotoxicity 💬
1件: IFNB 💬 Dazukibart 💬 Dazukibart 1件: 50 💬
21 Natural killer cell mediated cytotoxicity 💬
1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
22 Natural killer cell mediated cytotoxicity 💬
1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
23 Natural killer cell mediated cytotoxicity 💬
2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
24 Natural killer cell mediated cytotoxicity 💬
1件: ITGAL 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
25 Natural killer cell mediated cytotoxicity 💬
1件: ITGAL 💬 Efalizumab 💬 Efalizumab 9件: 11, 13, 37, 46, 53, 61, 95, 96, 221 💬
26 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
27 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
28 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
29 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
30 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
31 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
32 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
33 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
34 Natural killer cell mediated cytotoxicity 💬
5件: MHC1, MHC1, MHC1, MHC1, MHC1 💬 Glatiramer acetate 💬 Glatiramer 3件: 13, 96, 156 💬
35 Natural killer cell mediated cytotoxicity 💬
1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
36 Natural killer cell mediated cytotoxicity 💬
1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
37 Natural killer cell mediated cytotoxicity 💬
1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
38 Natural killer cell mediated cytotoxicity 💬
2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
39 Natural killer cell mediated cytotoxicity 💬
3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
40 Natural killer cell mediated cytotoxicity 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
41 Natural killer cell mediated cytotoxicity 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
42 Natural killer cell mediated cytotoxicity 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
43 Natural killer cell mediated cytotoxicity 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
44 Natural killer cell mediated cytotoxicity 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
45 Natural killer cell mediated cytotoxicity 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
46 Natural killer cell mediated cytotoxicity 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
47 Natural killer cell mediated cytotoxicity 💬
1件: SYK 💬 Fostamatinib 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
48 Natural killer cell mediated cytotoxicity 💬
1件: SYK 💬 Fostamatinib disodium 💬 Fostamatinib 5件: 46, 49, 61, 63, 66 💬
49 Natural killer cell mediated cytotoxicity 💬
1件: SYK 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
50 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
51 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
52 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
53 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
54 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
55 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
56 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
57 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
58 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
59 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
60 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬