Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 Blinatumomab 💬 Blinatumomab 3件: 11, 46, 49 💬
2 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 Muromonab-CD3 💬 Muromonab 3件: 60, 96, 97 💬
3 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
4 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
5 Th17 cell differentiation 💬
5件: CD3D, CD3E, CD3G, CD4, IL2RA 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
6 Th17 cell differentiation 💬
1件: CD3E 💬 Elranatamab 💬 Elranatamab 1件: 28 💬
7 Th17 cell differentiation 💬
1件: CD3E 💬 Imvotamab 💬 Imvotamab 2件: 46, 49 💬
8 Th17 cell differentiation 💬
1件: CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
9 Th17 cell differentiation 💬
1件: CD3E 💬 Talquetamab 💬 Talquetamab 1件: 28 💬
10 Th17 cell differentiation 💬
1件: CD3E 💬 Teclistamab 💬 Teclistamab 1件: 28 💬
11 Th17 cell differentiation 💬
1件: CD4 💬 Zanolimumab 💬 Zanolimumab 1件: 46 💬
12 Th17 cell differentiation 💬
1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
13 Th17 cell differentiation 💬
1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
14 Th17 cell differentiation 💬
2件: IFNGR1, IFNGR2 💬 Interferon gamma-1b 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
15 Th17 cell differentiation 💬
1件: IL17A 💬 Ixekizumab 💬 Ixekizumab 8件: 36, 37, 46, 107, 160, 162, 269, 271 💬
16 Th17 cell differentiation 💬
1件: IL17A 💬 Secukinumab 💬 Secukinumab 8件: 13, 37, 41, 46, 107, 160, 269, 271 💬
17 Th17 cell differentiation 💬
1件: IL17A 💬 Tibulizumab 💬 Tibulizumab 2件: 51, 53 💬
18 Th17 cell differentiation 💬
2件: IL17A, IL17F 💬 Bimekizumab 💬 Bimekizumab 5件: 37, 46, 97, 107, 271 💬
19 Th17 cell differentiation 💬
1件: IL1B 💬 Canakinumab 💬 Canakinumab 11件: 46, 54, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
20 Th17 cell differentiation 💬
1件: IL1B 💬 Gevokizumab 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
21 Th17 cell differentiation 💬
1件: IL1B 💬 Lutikizumab 💬 Lutikizumab 3件: 46, 96, 97 💬
22 Th17 cell differentiation 💬
1件: IL1B 💬 Rilonacept 💬 Rilonacept 5件: 51, 84, 106, 107, 266 💬
23 Th17 cell differentiation 💬
2件: IL1B, IL6 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 Th17 cell differentiation 💬
1件: IL1R1 💬 Anakinra 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 54, 56, 84, 86, 97, 106, 107, 266, 299 💬
25 Th17 cell differentiation 💬
1件: IL22 💬 Efmarodocokin alfa 💬 Efmarodocokin alfa 2件: 96, 97 💬
26 Th17 cell differentiation 💬
1件: IL23A 💬 Brazikumab 💬 Brazikumab 2件: 96, 97 💬
27 Th17 cell differentiation 💬
1件: IL23A 💬 Guselkumab 💬 Guselkumab 7件: 37, 41, 51, 96, 97, 161, 269 💬
28 Th17 cell differentiation 💬
1件: IL23A 💬 Mirikizumab 💬 Mirikizumab 3件: 37, 96, 97 💬
29 Th17 cell differentiation 💬
1件: IL23A 💬 Risankizumab 💬 Risankizumab 4件: 37, 96, 97, 271 💬
30 Th17 cell differentiation 💬
1件: IL23A 💬 Tildrakizumab 💬 Tildrakizumab 2件: 162, 271 💬
31 Th17 cell differentiation 💬
1件: IL23A 💬 Ustekinumab 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
32 Th17 cell differentiation 💬
1件: IL2RA 💬 Basiliximab 💬 Basiliximab 5件:  2 , 50, 97, 222, 228 💬
33 Th17 cell differentiation 💬
1件: IL2RA 💬 Daclizumab 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
34 Th17 cell differentiation 💬
3件: IL2RA, IL2RB, IL2RG 💬 Aldesleukin 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
35 Th17 cell differentiation 💬
1件: IL4R 💬 Dupilumab 💬 Dupilumab 5件: 51, 97, 98, 160, 162 💬
36 Th17 cell differentiation 💬
1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬
37 Th17 cell differentiation 💬
1件: IL6 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
38 Th17 cell differentiation 💬
1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬
39 Th17 cell differentiation 💬
1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬
40 Th17 cell differentiation 💬
1件: IL6R 💬 Sarilumab 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
41 Th17 cell differentiation 💬
1件: IL6R 💬 Satralizumab 💬 Satralizumab 4件: 11, 13, 86, 113 💬
42 Th17 cell differentiation 💬
1件: IL6R 💬 Tocilizumab 💬 Tocilizumab 24件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 149, 153, 266, 271, 298, 331 💬
43 Th17 cell differentiation 💬
1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 2件: 39, 84 💬
44 Th17 cell differentiation 💬
1件: JAK1 💬 Filgotinib 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
45 Th17 cell differentiation 💬
1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬
46 Th17 cell differentiation 💬
1件: JAK1 💬 Itacitinib adipate 💬 Itacitinib 4件: 46, 51, 97, 228 💬
47 Th17 cell differentiation 💬
1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
48 Th17 cell differentiation 💬
1件: JAK1 💬 Upadacitinib tartrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
49 Th17 cell differentiation 💬
1件: JAK1 💬 Upadacitinib hydrate 💬 Upadacitinib 10件: 40, 41, 46, 49, 53, 55, 96, 97, 107, 271 💬
50 Th17 cell differentiation 💬
2件: JAK1, JAK2 💬 Baricitinib 💬 Baricitinib 21件:  2 , 13, 40, 41, 46, 49, 50, 51, 53, 54, 84, 93, 107, 135, 162, 265, 268, 269, 300, 325, 345 💬
51 Th17 cell differentiation 💬
2件: JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
52 Th17 cell differentiation 💬
2件: JAK1, JAK2 💬 Ruxolitinib phosphate 💬 Ruxolitinib 6件: 13, 15, 50, 60, 65, 228 💬
53 Th17 cell differentiation 💬
3件: JAK1, JAK2, JAK3 💬 Gusacitinib 💬 Gusacitinib 1件: 49 💬
54 Th17 cell differentiation 💬
3件: JAK1, JAK2, JAK3 💬 Peficitinib 💬 Peficitinib 1件: 46 💬
55 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Delgocitinib 💬 Delgocitinib 1件: 50 💬
56 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Filgotinib maleate 💬 Filgotinib 10件: 46, 53, 56, 96, 97, 107, 222, 271, 300, 331 💬
57 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib citrate 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
58 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 Tofacitinib 💬 Tofacitinib 22件:  2 , 11, 35, 38, 39, 40, 44, 46, 49, 50, 51, 53, 65, 66, 84, 96, 97, 107, 110, 162, 271, 300 💬
59 Th17 cell differentiation 💬
1件: JAK2 💬 Pacritinib 💬 Pacritinib 1件: 331 💬
60 Th17 cell differentiation 💬
1件: JAK3 💬 Ritlecitinib tosylate 💬 Ritlecitinib 3件: 46, 96, 97 💬
61 Th17 cell differentiation 💬
1件: LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
62 Th17 cell differentiation 💬
1件: LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
63 Th17 cell differentiation 💬
14件: MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2, MHC2 💬 Glatiramer acetate 💬 Glatiramer 3件: 13, 96, 156 💬
64 Th17 cell differentiation 💬
1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
65 Th17 cell differentiation 💬
1件: MTOR 💬 Sirolimus 💬 Sirolimus 46件:  2 ,  6 , 13, 15, 17, 19, 21, 34, 35, 36, 46, 48, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 97, 98, 137, 157, 158, 192, 193, 222, 227, 256, 277, 278, 279, 280, 281, 283, 285, 300, 331 💬
66 Th17 cell differentiation 💬
1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
67 Th17 cell differentiation 💬
1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
68 Th17 cell differentiation 💬
4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
69 Th17 cell differentiation 💬
4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
70 Th17 cell differentiation 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
71 Th17 cell differentiation 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
72 Th17 cell differentiation 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
73 Th17 cell differentiation 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
74 Th17 cell differentiation 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
75 Th17 cell differentiation 💬
1件: PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
76 Th17 cell differentiation 💬
1件: PRKCQ 💬 Sotrastaurin acetate 💬 Sotrastaurin 1件: 97 💬
77 Th17 cell differentiation 💬
1件: RARA 💬 Fenretinide 💬 Fenretinide 1件: 299 💬
78 Th17 cell differentiation 💬
1件: RARA 💬 Isotretinoin 💬 Isotretinoin 4件: 36, 39, 159, 160 💬
79 Th17 cell differentiation 💬
1件: RARA 💬 Tamibarotene 💬 Tamibarotene 3件: 26, 67, 96 💬
80 Th17 cell differentiation 💬
1件: RARA 💬 Tretinoin 💬 Tretinoin 6件:  2 , 62, 63, 75, 94, 231 💬
81 Th17 cell differentiation 💬
1件: RARA 💬 Vitamin A 💬 Vitamin A 3件: 13, 53, 90 💬
82 Th17 cell differentiation 💬
4件: RARA, RXRA, RXRB, RXRG 💬 Acitretin 💬 Acitretin 1件: 37 💬
83 Th17 cell differentiation 💬
4件: RARA, RXRA, RXRB, RXRG 💬 Alitretinoin 💬 Alitretinoin 1件: 49 💬
84 Th17 cell differentiation 💬
2件: RARA, RXRB 💬 Tazarotene 💬 Tazarotene 1件: 85 💬
85 Th17 cell differentiation 💬
1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
86 Th17 cell differentiation 💬
3件: RXRA, RXRB, RXRG 💬 Bexarotene 💬 Bexarotene 2件: 13, 75 💬
87 Th17 cell differentiation 💬
1件: TGFB1 💬 Fresolimumab 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
88 Th17 cell differentiation 💬
1件: TYK2 💬 Deucravacitinib 💬 Deucravacitinib 9件: 36, 37, 49, 53, 84, 96, 97, 160, 269 💬
89 Th17 cell differentiation 💬
1件: TYK2 💬 Zasocitinib 💬 Zasocitinib 2件: 96, 97 💬