Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 T cell receptor signaling pathway 💬
 2件: CD28, ICOS 💬 Acazicolcept 💬 Acazicolcept 1件: 49 💬
2 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Blinatumomab 💬 Blinatumomab 3件: 11, 46, 49 💬
3 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Muromonab-CD3 💬 Muromonab 3件: 60, 96, 97 💬
4 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Otelixizumab 💬 Otelixizumab 1件: 46 💬
5 T cell receptor signaling pathway 💬
 3件: CD3D, CD3E, CD3G 💬 Visilizumab 💬 Visilizumab 2件: 96, 97 💬
6 T cell receptor signaling pathway 💬
 6件: CD3D, CD3E, CD3G, CD4, CD8A, CD8B 💬 Anti-human thymocyte immunoglobulin, rabbit 💬 Antithymocyte immunoglobulin (rabbit) 13件: 13, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286, 326 💬
7 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Elranatamab 💬 Elranatamab 1件: 28 💬
8 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Imvotamab 💬 Imvotamab 2件: 46, 49 💬
9 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Mosunetuzumab 💬 Mosunetuzumab 1件: 49 💬
10 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Talquetamab 💬 Talquetamab 1件: 28 💬
11 T cell receptor signaling pathway 💬
 1件: CD3E 💬 Teclistamab 💬 Teclistamab 1件: 28 💬
12 T cell receptor signaling pathway 💬
 1件: CD4 💬 Zanolimumab 💬 Zanolimumab 1件: 46 💬
13 T cell receptor signaling pathway 💬
 1件: CDK4 💬 Abemaciclib 💬 Abemaciclib 1件: 34 💬
14 T cell receptor signaling pathway 💬
 1件: CSF2 💬 Otilimab 💬 Otilimab 1件: 46 💬
15 T cell receptor signaling pathway 💬
 1件: CTLA4 💬 Ipilimumab 💬 Ipilimumab 1件: 159 💬
16 T cell receptor signaling pathway 💬
 1件: CTLA4 💬 Tremelimumab 💬 Tremelimumab 1件: 96 💬
17 T cell receptor signaling pathway 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
18 T cell receptor signaling pathway 💬
 2件: FYN, LCK 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
19 T cell receptor signaling pathway 💬
 1件: IFNG 💬 Emapalumab 💬 Emapalumab 5件: 49, 54, 60, 65, 107 💬
20 T cell receptor signaling pathway 💬
 1件: IFNG 💬 Fontolizumab 💬 Fontolizumab 1件: 46 💬
21 T cell receptor signaling pathway 💬
 2件: IL10, TNF 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
22 T cell receptor signaling pathway 💬
 1件: IL5 💬 Depemokimab 💬 Depemokimab 2件: 44, 45 💬
23 T cell receptor signaling pathway 💬
 1件: IL5 💬 Mepolizumab 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
24 T cell receptor signaling pathway 💬
 1件: IL5 💬 Reslizumab 💬 Reslizumab 2件: 44, 98 💬
25 T cell receptor signaling pathway 💬
 1件: ITK 💬 Soquelitinib 💬 Soquelitinib 1件: 65 💬
26 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
27 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
28 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib fumarate 💬 Cobimetinib 1件: 280 💬
29 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 4件: 34, 278, 279, 280 💬
30 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
31 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib sulfate 💬 Selumetinib 1件: 34 💬
32 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
33 T cell receptor signaling pathway 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib dimethyl sulfoxide 💬 Trametinib 6件:  2 , 34, 58, 195, 279, 280 💬
34 T cell receptor signaling pathway 💬
 1件: NFKB1 💬 Iguratimod 💬 Iguratimod 6件: 46, 49, 51, 53, 271, 300 💬
35 T cell receptor signaling pathway 💬
 4件: P38, P38, P38, P38 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
36 T cell receptor signaling pathway 💬
 4件: P38, P38, P38, P38 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
37 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Nivolumab 💬 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
38 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Pembrolizumab 💬 Pembrolizumab 2件: 25, 285 💬
39 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Peresolimab 💬 Peresolimab 1件: 46 💬
40 T cell receptor signaling pathway 💬
 1件: PDCD1 💬 Rosnilimab 💬 Rosnilimab 2件: 46, 97 💬
41 T cell receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Alpelisib 💬 Alpelisib 4件: 138, 278, 279, 280 💬
42 T cell receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Leniolisib phosphate 💬 Leniolisib 2件: 53, 65 💬
43 T cell receptor signaling pathway 💬
 1件: PIK3CA_B_D 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
44 T cell receptor signaling pathway 💬
 2件: PIK3CA_B_D, PIK3CA_B_D 💬 Copanlisib 💬 Copanlisib 1件: 121 💬
45 T cell receptor signaling pathway 💬
 3件: PIK3CA_B_D, PIK3CA_B_D, PIK3CA_B_D 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
46 T cell receptor signaling pathway 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
47 T cell receptor signaling pathway 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
48 T cell receptor signaling pathway 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
49 T cell receptor signaling pathway 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
50 T cell receptor signaling pathway 💬
 5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
51 T cell receptor signaling pathway 💬
 1件: PRKCQ 💬 Sotrastaurin 💬 Sotrastaurin 1件: 97 💬
52 T cell receptor signaling pathway 💬
 1件: PRKCQ 💬 Sotrastaurin acetate 💬 Sotrastaurin 1件: 97 💬
53 T cell receptor signaling pathway 💬
 1件: RAF1 💬 Sorafenib tosylate 💬 Sorafenib 2件: 34, 86 💬
54 T cell receptor signaling pathway 💬
 1件: RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
55 T cell receptor signaling pathway 💬
 1件: RELA 💬 Edasalonexent 💬 Edasalonexent 1件: 113 💬
56 T cell receptor signaling pathway 💬
 1件: TNF 💬 Adalimumab 💬 Adalimumab 21件: 19, 37, 38, 40, 41, 46, 55, 56, 84, 96, 97, 107, 151, 160, 162, 164, 222, 226, 269, 270, 271 💬
57 T cell receptor signaling pathway 💬
 1件: TNF 💬 Certolizumab pegol 💬 Certolizumab pegol 7件: 37, 46, 49, 96, 107, 226, 271 💬
58 T cell receptor signaling pathway 💬
 1件: TNF 💬 Etanercept 💬 Etanercept 16件: 15, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
59 T cell receptor signaling pathway 💬
 1件: TNF 💬 Golimumab 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
60 T cell receptor signaling pathway 💬
 1件: TNF 💬 Infliximab 💬 Infliximab 25件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 107, 164, 269, 270, 271 💬
61 T cell receptor signaling pathway 💬
 1件: TNF 💬 Lenalidomide 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
62 T cell receptor signaling pathway 💬
 1件: TNF 💬 Ozoralizumab 💬 Ozoralizumab 1件: 46 💬
63 T cell receptor signaling pathway 💬
 1件: TNF 💬 Pegsunercept 💬 Pegsunercept 1件: 46 💬
64 T cell receptor signaling pathway 💬
 1件: TNF 💬 Pomalidomide 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
65 T cell receptor signaling pathway 💬
 1件: TNF 💬 Thalidomide 💬 Thalidomide 21件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 117, 227, 271, 280, 298, 300, 331 💬
66 T cell receptor signaling pathway 💬
 1件: TNFSF5 💬 Frexalimab 💬 Frexalimab 2件: 13, 222 💬
67 T cell receptor signaling pathway 💬
 1件: TNFSF5 💬 Toralizumab 💬 Toralizumab 1件: 63 💬