Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Amlodipine besylate 💬 Amlodipine 3件: 51, 67, 298 💬
2 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Amlodipine maleate 💬 Amlodipine 3件: 51, 67, 298 💬
3 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Amlodipine 💬 Amlodipine 3件: 51, 67, 298 💬
4 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Amlodipine benzoate 💬 Amlodipine 3件: 51, 67, 298 💬
5 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Bevantolol hydrochloride 💬 Bevantolol 1件:  8  💬
6 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Cilnidipine 💬 Cilnidipine 1件: 67 💬
7 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Diltiazem hydrochloride 💬 Diltiazem 4件: 51, 58, 86, 88 💬
8 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Diltiazem malate 💬 Diltiazem 4件: 51, 58, 86, 88 💬
9 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Diltiazem 💬 Diltiazem 4件: 51, 58, 86, 88 💬
10 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Isradipine 💬 Isradipine 1件:  6  💬
11 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Nicardipine hydrochloride 💬 Nicardipine 2件: 70, 86 💬
12 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Nicardipine 💬 Nicardipine 2件: 70, 86 💬
13 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Nifedipine 💬 Nifedipine 1件: 81 💬
14 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Nilvadipine 💬 Nilvadipine 1件: 90 💬
15 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Perhexiline maleate 💬 Perhexiline 2件: 58, 272 💬
16 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Perhexiline 💬 Perhexiline 2件: 58, 272 💬
17 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Propiverine hydrochloride 💬 Propiverine 1件: 226 💬
18 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Propiverine 💬 Propiverine 1件: 226 💬
19 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Verapamil hydrochloride 💬 Verapamil 4件: 58, 96, 140, 167 💬
20 Glutamatergic synapse 💬
2件: CACNA1C, CACNA1D 💬 Verapamil 💬 Verapamil 4件: 58, 96, 140, 167 💬
21 Glutamatergic synapse 💬
11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 Topiramate 💬 Topiramate 5件:  6 , 140, 144, 156, 193 💬
22 Glutamatergic synapse 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel 💬 Perampanel 3件:  2 ,  6 , 144 💬
23 Glutamatergic synapse 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 Perampanel hydrate 💬 Perampanel 3件:  2 ,  6 , 144 💬
24 Glutamatergic synapse 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 Talampanel 💬 Talampanel 2件:  2 ,  6  💬
25 Glutamatergic synapse 💬
14件: GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Riluzole 💬 Riluzole 8件:  2 ,  3 ,  5 ,  8 , 13, 17, 203, 206 💬
26 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate calcium 💬 Acamprosate 2件:  6 , 206 💬
27 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Acamprosate 💬 Acamprosate 2件:  6 , 206 💬
28 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine hydrochloride 💬 Amantadine 5件:  2 ,  6 ,  8 , 13, 127 💬
29 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Amantadine 💬 Amantadine 5件:  2 ,  6 ,  8 , 13, 127 💬
30 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan hydrobromide 💬 Dextromethorphan 10件:  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
31 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Dextromethorphan 💬 Dextromethorphan 10件:  2 ,  6 ,  8 , 13, 21, 46, 85, 96, 97, 156 💬
32 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
33 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Esketamine hydrochloride 💬 Esketamine 7件:  2 ,  4 ,  6 , 70, 96, 97, 156 💬
34 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine hydrochloride 💬 Ketamine 6件:  6 , 13, 70, 113, 156, 215 💬
35 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Ketamine 💬 Ketamine 6件:  6 , 13, 70, 113, 156, 215 💬
36 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine 💬 Latrepirdine 1件:  8  💬
37 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Latrepirdine dihydrochloride 💬 Latrepirdine 1件:  8  💬
38 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine hydrochloride 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
39 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
40 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone hydrochloride 💬 Methadone 1件: 60 💬
41 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Methadone 💬 Methadone 1件: 60 💬
42 Glutamatergic synapse 💬
5件: GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 Tenocyclidine 💬 Tenocyclidine 1件: 36 💬
43 Glutamatergic synapse 💬
1件: KCNJ3 💬 Amiodarone hydrochloride 💬 Amiodarone 1件: 127 💬
44 Glutamatergic synapse 💬
1件: KCNJ3 💬 Amiodarone 💬 Amiodarone 1件: 127 💬
45 Glutamatergic synapse 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
46 Glutamatergic synapse 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Pimecrolimus 💬 Pimecrolimus 1件: 160 💬
47 Glutamatergic synapse 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Tacrolimus 💬 Tacrolimus 33件:  2 ,  6 , 11, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 234, 283, 284, 285, 286, 299 💬
48 Glutamatergic synapse 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Voclosporin 💬 Voclosporin 2件: 49, 222 💬
49 Glutamatergic synapse 💬
5件: PPP3C, PPP3C, PPP3C, PPP3R, PPP3R 💬 Cyclosporine 💬 Cyclosporine 42件: 11, 19, 20, 26, 28, 36, 40, 41, 42, 45, 46, 49, 50, 53, 54, 55, 56, 58, 60, 61, 62, 63, 64, 65, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
50 Glutamatergic synapse 💬
1件: PRKCB 💬 Enzastaurin hydrochloride 💬 Enzastaurin 1件: 168 💬
51 Glutamatergic synapse 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬